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Table 2 Study assessments

From: Comparing high altitude treatment with current best care in Dutch children with moderate to severe atopic dermatitis (and asthma): study protocol for a pragmatic randomized controlled trial (DAVOS trial)

Assessment

Measured with

T-1

T0

T1

T2

T3

Coping with itch and disease

JUCKKI-COPECI (8-12 yr) or JUCKJU-COPEJU (13-18 yr) [23]

x

x

x

x

x

Disease-specific quality of life

CDQLI [31]

x

x

x

x

x

Disease activity and control (AD)

EASI [33]

x

x

x

x

x

 

SA-EASI [25]

x

x

x

x

x

 

Used topical corticosteroids

x

x

x

x

x

 

TARC [34]

x

x

x

x

x

Disease activity and control (Asthma)

ACQ [35]

x

x

x

x

x

 

PAQLQ [36]

x

   

x

 

Lung function test

x

x

x

x

x

 

FeNO

x

x

x

x

x

 

Used medication

x

x

x

x

x

 

Metacholine provocation

x

x

x

x

x

Serum

Total IgE

 

x

  

x

 

Specific IgE: inhalation/food: ImmunoCAP

 

x

  

x

 

Specific IgE: inhalation/food: ImmunoCAP ISAC

 

x

   
 

Eosinophils

 

x

x

x

x

 

Cytokine profile

 

x

x

x

x

Questionnaires

Social demographic information

x

    
 

Intelligence test [37]

x

    
 

SF-36 [38, 39]

x

    
 

CBCL [40, 41]

x

    
 

Corticosteroid use

x

  

x

x

 

NPV-J [42]

x

    
 

TRF [40]

x

    
 

CBSK/CBSA [43, 44]

x

 

x

 

x

 

ZBV-K [45]

x

x

x

 

x

 

PUL (>12 yr) [46]

x

 

x

 

x

 

Quality of life (parents) [47]

x

x

x

 

x

 

ZBV [48]

x

 

x

 

x

 

NOSI-K [49]

x

 

x

 

x

 

NOSI-events [49]

x

   

x

Other

Maximal cycle ergometer test

x

   

x

 

Bacterial colonization of the skin

 

x

x

x

x

 

Bacterial colonization of the nose

 

x

x

x

x

 

Skin strips for protease activity

 

x

x

x

x

  1. ACQ, asthma control questionnaire; CBCL, child behavior checklist; CBSK, self-perception profile for children; CBSA, self-perception profile for adolescents; CDQLI, the children’s dermatology life quality index; COPEKI/COPEJU, coping with disease questionnaire; EASI, eczema area and severity index; FeNO, fraction of exhaled nitric oxide; IgE, Immunoglobulin E; ImmunoCAP, ImmunoCAP system (Thermo Fisher Scientific, Uppsala, Sweden); ImmunoCAP ISAC, Immunosolid-phase allergen chip (Thermo Fisher Scientific, Uppsala, Sweden); JUCKKI/JUCKJU, itching cognitions questionnaire; NOSI-events, parental stress index-events; NOSI-K, parental stress index- short form; NPV-J, Dutch personality questionnaire-youth version; PAQLQ, pediatric asthma quality of life questionnaire;
  2. PUL, positive outcome list; SA-EASI, self-administered eczema area and severity index; SF-36, short form health survey; TARC, thymus and activation-regulated chemokine; T-1, assessment at start of participation in trial; T0, assessment before start of the intervention; T1, assessment direct after the intervention; T2, assessment six weeks after the intervention; T3, assessment six months after the intervention; TRF, teacher report form; ZBV, state-trait anxiety inventory; ZBV-K, state-trait anxiety inventory for children.