Table 2 Co-enrollment fractions and resultant sample size with 3% antagonistic interaction
From: Ethical and scientific considerations for patient enrollment into concurrent clinical trials
Co-enrollment fraction | Event rate for arm S1 | Event rate for arm S2 | Difference | Number of patients per arm for 90% power |
|---|---|---|---|---|
0% | 7.64 | 8.38 | -0.74 | 28,249 |
30% | 7.69 | 8.36 | -0.67 | 34,715 |
50% | 7.72 | 8.34 | -0.62 | 40,335 |
70% | 7.75 | 8.32 | -0.57 | 47,432 |
100% | 7.80 | 8.30 | -0.50 | 62,161 |