Figure 2
From: Ethical and scientific considerations for patient enrollment into concurrent clinical trials
Sample size per arm to detect a difference between interventions in Trial S with 90% power for 4 scenarios according to co-enrolled fraction in later Trial T. Scenario (1) corresponds to treatment T1 of Trial T used for all non-co-enrolled patients. Scenarios (2) and (3) correspond to preferential use of T1 in non-co-enrolled patients depending on their severity. Scenario (4) corresponds to no use of T1 in non-co-enrolled patients.