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Figure 6 | Trials

Figure 6

From: Long-term outcome of the humoral and cellular immune response of an H5N1 adjuvanted influenza vaccine in elderly persons: 2-year follow-up of a randomised open-label study

Figure 6

CD4 + T cells specific for A/Vietnam/1194/2004 split-virus antigen, positive for ≥2 immunological markers. Antigen-specific CD4+ T cells expressing ≥2 of the following immunological markers: CD40L, interleukin-2, tumour necrosis factor alpha, or interferon-gamma. Line inside the box, median value; top line of box, third quartile; bottom line of box, first quartile; lower limit of error bar, minimum value; upper limit of error bar, maximum value. Vaccination groups are: 1xH5N1-AS, single dose of the AS03A-adjuvanted vaccine; 1xH5N1, single dose of the non-adjuvanted vaccine; 2xH5N1-AS, double dose of the AS03A-adjuvanted vaccine; 2xH5N1, double dose of the non-adjuvanted vaccine. Post-vaccination = day 42 (data also shown in [13]). Post-vaccination results are shown for the according-to-protocol immunogenicity cohort (1xH5N1-AS: N =120, 1xH5N1: N =43, 2xH5N1-AS: N =118, 2xH5N1: N =30), month 12 results for the month 12 according-to-protocol persistence cohort (1xH5N1-AS: N =90, 1xH5N1: N =41, 2xH5N1-AS: N =91, 2xH5N1: N =30) and month 24 results for the month 24 according-to-protocol persistence cohort (1xH5N1-AS: N =73, 1xH5N1: N =34, 2xH5N1-AS: N =72, 2xH5N1: N =22); N = number of participants with available results.

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Trials

ISSN: 1745-6215