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Table 5 Respondents’ reasons for withholding clinical trial data*

From: Predictors of clinical trial data sharing: exploratory analysis of a cross-sectional survey

  Reasons for withholding clinical trial data*
  Respondents Protect investigator or funder interests (%) P value Protect research subjects (%) P value Ensure appropriate data use (%) P value Other reasons (%)
Overall 317 121 (38)   107 (34)   233 (74)   37 (12)
Trialist academic productivity (number of research articles published in past three years)    0.32   0.01   0.31  
     1 to 10 articles 71 22 (31)   29 (41)   55 (77)   3 (4)
     11 to 25 articles 117 45 (38) 47 (40) 89 (76) 18 (15)
     >25 articles 129 54 (42) 31 (24) 89 (69) 16 (12)
Trialist geographic location    0.72   0.79   0.40  
     United States or Canada 167 66 (40)   57 (34)   123 (74)   22 (13)
     Western Europe 113 43 (38) 36 (32) 86 (76) 14 (12)
     Other 37 12 (32) 14 (38) 24 (65) 1 (3)
Trial funding source    0.65   0.003   0.92  
     Government 120 43 (36)   50 (42)   89 (74)   13 (11)
     Industry or mixed funding 152 62 (41) 37 (24) 112 (74) 17 (11)
     Other 45 16 (36) 20 (44) 32 (71) 7 (16)
Trial size    0.45   0.08   0.75  
     ≤239 subjects 80 26 (33)   35 (44)   58 (73)   7 (9)
     240 to 2,016 subjects 158 62 (39) 50 (32) 119 (75) 20 (13)
     ≥2,017 subjects 79 33 (42) 22 (28) 56 (71) 10 (13)
Journal in which the trial was published    0.11   0.0008**   0.86  
     NEJM 113 50 (44)   30 (27)   85 (75)   15 (13)
     Lancet 70 22 (31) 18 (26) 49 (70) 10 (14)
     JAMA 43 11 (26) 15 (35) 34 (79) 4 (9)
     Annals of Internal Medicine 24 11 (46) 16 (67) 17 (71) 3 (13)
     The BMJ 53 19 (36) 25 (47) 37 (70) 5 (9)
     PLoS Medicine 14 8 (57)   3 (21)   11 (79)   0 (0)
  1. *If respondent had not been asked to share data they were asked to share their hypothetical reasons for not sharing. **Fisher exact test. JAMA, Journal of the American Medical Association; NEJM, New England Journal of Medicine.