Table 5 Respondents’ reasons for withholding clinical trial data*
From: Predictors of clinical trial data sharing: exploratory analysis of a cross-sectional survey
| Â | Reasons for withholding clinical trial data* | |||||||
|---|---|---|---|---|---|---|---|---|
| Â | Respondents | Protect investigator or funder interests (%) | P value | Protect research subjects (%) | P value | Ensure appropriate data use (%) | P value | Other reasons (%) |
Overall | 317 | 121 (38) | Â | 107 (34) | Â | 233 (74) | Â | 37 (12) |
Trialist academic productivity (number of research articles published in past three years) | Â | Â | 0.32 | Â | 0.01 | Â | 0.31 | Â |
     1 to 10 articles | 71 | 22 (31) |  | 29 (41) |  | 55 (77) |  | 3 (4) |
     11 to 25 articles | 117 | 45 (38) | 47 (40) | 89 (76) | 18 (15) | |||
     >25 articles | 129 | 54 (42) | 31 (24) | 89 (69) | 16 (12) | |||
Trialist geographic location | Â | Â | 0.72 | Â | 0.79 | Â | 0.40 | Â |
     United States or Canada | 167 | 66 (40) |  | 57 (34) |  | 123 (74) |  | 22 (13) |
     Western Europe | 113 | 43 (38) | 36 (32) | 86 (76) | 14 (12) | |||
     Other | 37 | 12 (32) | 14 (38) | 24 (65) | 1 (3) | |||
Trial funding source | Â | Â | 0.65 | Â | 0.003 | Â | 0.92 | Â |
     Government | 120 | 43 (36) |  | 50 (42) |  | 89 (74) |  | 13 (11) |
     Industry or mixed funding | 152 | 62 (41) | 37 (24) | 112 (74) | 17 (11) | |||
     Other | 45 | 16 (36) | 20 (44) | 32 (71) | 7 (16) | |||
Trial size | Â | Â | 0.45 | Â | 0.08 | Â | 0.75 | Â |
     ≤239 subjects | 80 | 26 (33) |  | 35 (44) |  | 58 (73) |  | 7 (9) |
     240 to 2,016 subjects | 158 | 62 (39) | 50 (32) | 119 (75) | 20 (13) | |||
     ≥2,017 subjects | 79 | 33 (42) | 22 (28) | 56 (71) | 10 (13) | |||
Journal in which the trial was published | Â | Â | 0.11 | Â | 0.0008** | Â | 0.86 | Â |
     NEJM | 113 | 50 (44) |  | 30 (27) |  | 85 (75) |  | 15 (13) |
     Lancet | 70 | 22 (31) | 18 (26) | 49 (70) | 10 (14) | |||
     JAMA | 43 | 11 (26) | 15 (35) | 34 (79) | 4 (9) | |||
     Annals of Internal Medicine | 24 | 11 (46) | 16 (67) | 17 (71) | 3 (13) | |||
     The BMJ | 53 | 19 (36) | 25 (47) | 37 (70) | 5 (9) | |||
     PLoS Medicine | 14 | 8 (57) |  | 3 (21) |  | 11 (79) |  | 0 (0) |