Figure 3
From: Meta-analysis of randomized phase II trials to inform subsequent phase III decisions
Comparison of Bayesian prediction interval from Phase II meta-analysis with original meta-analysis and subsequent Phase III trials for ICH. lnTIME-II, ASSENT-2, BIRD, GUSTO-III, COBALT and INJECT are the six subsequent Phase III trials, which compared bolus to infusion therapy for patients with an acute myocardial infarction. Horizontal lines indicate the 95% confidence intervals for the estimated log ORs in the Phase III trials and the original Phase II meta-analysis, and the 95% prediction interval in the Bayesian Phase II meta-analysis [22–27].