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Table 2 List of topics identified as priorities by more than one Clinical Trials Unit (CTU) Director from round one (primary list) ordered by round three priority ranks

From: The trials methodological research agenda: results from a priority setting exercise

  Round 2 (32 responders) Round 3 (24 responders)   
Topic 1 to 3 Scores* 4 to 6 7 to 9 1 to 3 Scores* 4 to 6 7 to 9   
% responders % responders Consensus? Rank
Methods to boost recruitment 0.0 43.8 56.3 0.0 16.7 83.3 Consensus in 1
Choosing appropriate outcomes to measure 3.1 28.1 68.8 0.0 29.2 70.8 Consensus in 2
Methods to minimise attrition 6.3 40.6 53.1 0.0 29.2 70.8 Consensus in 2
Methods to minimise bias in trials when blinding is not possible 0.0 40.6 59.4 0.0 33.3 66.7   4
Pragmatic trials 0.0 56.3 43.8 0.0 45.8 54.2   5
Design and analysis of pilot/feasibility trials 6.3 46.9 46.9 4.2 41.7 54.2   6
Calculating sample size 21.9 31.3 46.9 12.5 33.3 54.2   7
Methods for dealing with missing data 3.1 59.4 37.5 0.0 58.3 41.7   8
Phase II trials 15.6 50.0 34.4 16.7 50.0 33.3   9
Complex interventions 3.1 62.5 34.4 0.0 70.8 29.2   10
Consent in emergency settings 12.5 46.9 40.6 0.0 70.8 29.2   10
Methods for trial monitoring 9.4 65.6 25.0 8.3 62.5 29.2   12
Adjustment for non-adherence to treatment protocol 6.3 53.1 40.6 4.2 70.8 25.0   13
Stratified medicine design 6.3 56.3 37.5 8.3 66.7 25.0   14
Primary care trials 18.8 56.3 25.0 12.5 62.5 25.0   15
Interim analysis/Data Monitoring issues 9.4 65.6 25.0 0.0 79.2 20.8   16
Adaptive designs 0.0 62.5 37.5 4.2 75.0 20.8   17
Equivalence/non-inferiority trials 12.5 62.5 25.0 12.5 66.7 20.8   18
Dealing with clustering effects 6.3 65.6 28.1 4.2 79.2 16.7   19
Methods for economic analysis 12.5 65.6 21.9 8.3 75.0 16.7   20
Cluster trials 12.5 62.5 25.0 12.5 70.8 16.7   21
Evaluation of electronic data capture methods 28.1 50.0 21.9 20.8 62.5 16.7   22
e-trials 12.5 62.5 25.0 8.3 79.2 12.5   23
Multi-arm Multi-stage (MAMS) designs 12.5 75.0 12.5 12.5 75.0 12.5   24
Stepped wedge designs 15.6 65.6 18.8 16.7 75.0 8.3   25
Randomisation methods 34.4 53.1 12.5 33.3 58.3 8.3   26
Multiplicity 15.6 81.3 3.1 8.3 87.5 4.2   27
Radiotherapy study designs 59.4 34.4 6.3 75.0 20.8 4.2 Consensus out 28
  1. *Scores 1 to 3: topic not important; Scores 4 to 6: topic important but not critical; Scores 7 to 9: topic critical.