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Comparative study of new imaging technologies for the diagnosis of glaucoma: design and conduct of a multi-centre diagnostic accuracy study
Trials volume 14, Article number: O45 (2013)
The detection and diagnosis of glaucoma is challenging for health professionals. In the UK, approximately 45% of patients are discharged from secondary care after one visit.
Automated imaging technologies are easy to perform and could potentially be used by trained technicians as triage tests for glaucoma diagnosis.
The GATE study aims to compare the diagnostic performance of three technologies, Heidelberg Retina Tomograph (HRT-III), Scanning laser polarimetry (GDx-ECC) and Optical Coherence Tomography (Spectralis), as triage tests in secondary care for glaucoma diagnosis.
Diagnostic accuracy study, comparing 3 imaging techniques for glaucoma diagnosis.
Adult patients, newly referred from community to hospital eye services for suspected glaucoma.
Comprehensive clinical examination by experienced consultant ophthalmologist, including fundus examination and visual field tests.
954, each imaged using all three technologies.
NHS secondary care, UK.
Diagnostic performance measures, economic outcomes.
Data uploaded at site via secure web-based data-collection system.
Recruitment commenced April 2011. To date, 874 participants have been enrolled from five UK hospitals. GATE is an on-going research study and will be completed in November 2013.
Conducting a multicentre diagnostic accuracy study in ophthalmology is challenging. Problems which were overcome are grouped into: difficulties in site set-up, consensus in agreeing a reference standard and agreeing study processes. Solutions were achieved through careful planning and support from site based staff.
Challenges in setting up and running a large diagnostic accuracy study can be overcome given adequate resource and planning. http://www.abdn.ac.uk/chart/gate.
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Banister, K., Cook, J., Ramsay, C. et al. Comparative study of new imaging technologies for the diagnosis of glaucoma: design and conduct of a multi-centre diagnostic accuracy study. Trials 14, O45 (2013). https://doi.org/10.1186/1745-6215-14-S1-O45
- Optical Coherence Tomography
- Triage Test
- Diagnostic Performance
- Secondary Care