Table 1 Delivery of renal replacement therapy in the trial
Intermittent hemodialysis | Sustained low-efficiency dialysis | Continuous renal replacement therapy | |
|---|---|---|---|
Patient hemodynamic profile | Off all vasopressors and inotropes (SOFAcv <2) | Receiving any dose of vasopressor or inotrope (SOFAcv ≥2) | Receiving any dose of vasopressor or inotrope (SOFAcv ≥2) |
Minimum session duration (hrs) | 3 | 8 | 24 |
Minimum frequency | 3 times/week | 3 times/week | NA |
Blood flow target (mL/min) | 200 to 400 | 200 to 300 | 100 to 250 |
Dialysate flow (mL/min) | 500 to 800 | 200 to 400 | NA |
Total effluent (mL/kg/hr) | NA | NA | ≥25 |
Anticoagulation options | Heparin | Heparin | Heparin |
None | None | None | |
Regional citrate anticoagulation | |||
Fluid removal rate | To be determined by the nephrologist and/or critical care physician | ||