ADAPT Triple Negative
trial design. Triple negative (HER2-/HR-) patients are treated with either nab-Paclitaxel and Gemcitabine or nab-Paclitaxel and Carboplatin for induction therapy, which is subject to randomization. Randomization is only applicable after HR and HER2 status are confirmed by central pathology. The randomized regimen is applied in the neoadjuvant setting for twelve weeks followed by surgery.