Inclusion criteria | Exclusion criteria |
---|---|
Definitive diagnosis of MS | Depression (HADS depression >11) |
Severely fatigued (CIS20r-fatigue ≥35) | Primary sleep disorders |
Aged between 18 and 70 years | Severe co-morbidity (CIRS item scores ≥3) |
Ambulatory patients (an EDSS score ≤6) | Current pregnancy or having given birth in the past 3 months |
No evident signs of an exacerbation or a corticosteroid treatment in the past 3 months | Pharmacological treatment for fatigue in the past 3 months |
No infections (normal leukocytes and C-reactive protein in blood) | Non-pharmacological therapies for fatigue in the past 3 months |
No anaemia (normal haemoglobin and haematocrit in blood) | Â |
No thyroid dysfunction (normal thyroid stimulating hormone (TSH) in blood) | Â |