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Figure 4 | Trials

Figure 4

From: Impact of lack-of-benefit stopping rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome

Figure 4

Development of overall survival log hazard ratio over time in ICON4 trial. Gray curves are the corresponding 95% CIs. The dashed horizontal line shows the overall (underlying) effect. The vertical dotted lines specify the interim analysis time points (see text for calendar time) where stage 1 analysis is carried out based on different design significance levels α 1 – the I outcome is PFS.

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Trials

ISSN: 1745-6215