Figure 2From: Impact of lack-of-benefit stopping rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome Log hazard ratio pairs of (PFS, OS) simulated from a bivariate normal distribution with mean (log(0.8), log(0.8)) and a correlation coefficient of 0.8. δ I is the predefined threshold. Blue circles and red crosses represent selected and dropped trials, respectively. OS, overall survival, PFS, progress-free survival.Back to article page