Table 2 Model inputs
Model inputs | Estimates | Distributions |
|---|---|---|
Short-term clinical outcome (routine care)a | ||
Probability of… | ||
In-hospital mortality | 0.129 | DirichletI (52, 26, 2, 162,160) |
Cardiovascular complications | 0.065 | |
Stroke | 0.005 | |
Other complications | 0.403 | |
uncomplicated recovery | 0.398 | |
Relative risk of mortality GDHT versus routine [8] | 0.75 | Lognormal (−0.28; 0.09) |
Relative risk of complications GDHT versus routine | 0.81 | Lognormal |
Long-term clinical outcome (routine care) | ||
Mortality associated with cardiovascular diseaseb | ||
First year | 0.107 | Deterministic |
Second year | 0.058 | Deterministic |
Third year | 0.056 | Deterministic |
Mortality associated with stroke at 3 monthsc | 0.15 | Deterministic |
Mortality associated with other complicationsa | 0.18 | Beta (31; 140) |
Recovery associated with other complicationsa | 0.41 | Beta (70; 101) |
Mortality after recovery with other complicationsa | 0.15 | Beta (17; 95) |
Costs/patient for routine fluid treatment in the clinical routine (€)d | ||
Medical device for fluid treatment | 11 | Deterministic |
Human resources in pre-operative area | 27 | Deterministic |
Human resources during anesthesia | 117 | Deterministic |
Costs/patient for GDHT (€)d | ||
Medical device for GDHT | 221 | Deterministic |
Human resources in pre-operative area | 159 | Deterministic |
Human resources during anesthesia | 401 | Deterministic |
Post-operative direct health-care costs/patient (€)e | ||
Cardiovascular complications | ||
Myocardial infarction | 7,498 | Gamma (90; 83) |
Heart failure | 9,903 | Gamma (104;95) |
Stroke | 7,550 | Gamma (8; 956) |
Other complications | ||
Pneumonia | 8,514 | Gamma (106; 81) |
Renal failure | 12,197 | Gamma (6; 1442) |
Wound infection | 8,566 | Gamma (218; 39) |
Deep-vein thrombosis | 7,617 | Gamma (62; 124) |
Pulmonary embolism | 10,190 | Gamma (17, 600) |
Gastrointestinal bleeding | 9,900 | Gamma (64, 154) |
Confusion | 7,961 | Gamma (866; 9) |
Death | 9,020 | Gamma (273, 33) |
No complications | 6,753 | Gamma (956; 7) |
Direct health-care costs, first year after hospital stay (€)f | ||
State after… | ||
No complications | 147 | Deterministic |
Cardiovascular complications | 7,673 | Deterministic |
Stroke | 7,512 | Deterministic |
Other complications | 7,314 | Deterministic |
Recovery from other complications | 396 | Deterministic |
Death | 4,837 | Deterministic |
Direct health-care costs, 2 to 10 year after hospital stay (€)f | ||
State after… | ||
Cardiovascular complications | 386 | Deterministic |
Stroke | 402 | Deterministic |
Other complications | 396 | Deterministic |
QALY weights, estimates [7] | ||
>80 years age | 0.74 | Beta (322; 113) |
Recovered after other complication [9] | 0.66 | Beta (227; 117) |
Decrements of QALY weights [8] | ||
State after… | ||
Cardiovascular complications | −0.19 | Gamma (298; 0.0006) |
Stroke | −0.35 | Gamma (100; 0.0035) |
Other complications | −0.15 | Gamma (100; 0.0007) |