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Table 7 Probability distributions of the calculated boundaries a

From: Introduction to a generalized method for adaptive randomization in trials

Interval

Strongb,c

Mediumb

Weakb

[0, 0.05]

17184

2275

6

 

34%

5%

<1%

(0.05, 0.15]

2506

3394

233

 

5%

7%

<1%

(0.15, 0.25]

0

4157

1055

 

0%

8%

2%

(0.25, 0.35]

2795

4367

2963

 

6%

9%

6%

(0.35, 0.45]

0

5921

8372

 

0%

12%

17%

(0.45, 0.55]

5121

10181

25155

 

10%

20%

50%

(0.55, 0.65]

0

5897

8112

 

0%

12%

16%

(0.65, 0.75]

2887

4188

2852

 

6%

8%

6%

(0.75, 0.85]

0

4125

1015

 

0%

8%

2%

(0.85, 0.95]

2363

3365

231

 

5%

7%

<1%

(0.95, 1]

17144

2130

6

 

34%

4%

<1%

  1. aSimple randomization has not been included here as the boundary is always at 0.5.
  2. bThe frequency (%) of the calculated boundaries that occured in each of the intervals is shown.
  3. cFor the strong control scenario all boundaries in the (0.45, 0.55] interval are 0.5.