Introduction to a generalized method for adaptive randomization in trials

Table 4 Imbalances seen within gender across the 1,000 simulations

Difference^a	Strong	Medium	Weak	Simple randomization
<−7				117
−7			5	56
−6			20	76
−5			46	101
−4		3	110	105
−3		44	165	157
−2	74	214	217	126
−1	506	466	278	172
0	829	543	304	167
1	514	467	264	154
2	77	222	231	169
3		39	184	151
4		2	105	114
5			49	94
6			19	68
7			3	32
>7				141

^aA difference of −7 indicates that there were seven more participants allocated to treatment group B than treatment group A.

ISSN: 1745-6215