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Table 2 Analysis of efficacy adjusting for prior use of cannabis

From: Assessment of blinding to treatment allocation in studies of a cannabis-based medicine (Sativex®) in people with multiple sclerosis: a new approach

Source

P-value

 

Model 1

Model 2

Model 3

Model 4

Model 5

Baseline severity (BS)

    

<0.0001

Study (ST)

    

0.052

Prior cannabis (PC)

    

0.105

Treatment group (TG)

    

0.033

TG*PC

0.962

0.637

0.561

0.626

 

PC*ST

0.497

0.514

0.495

  

TG*ST

0.810

0.720

   

TG*PC*ST

0.188

    

Estimated effect of previous cannabis use on spasticity NRS (95% CI)

Previous users:

−1.23 (−1.43 to −1.04)

No previous use:

−0.98 (−1.22 to −0.74)

Estimated difference:

−0.25 (−0.56 to 0.05)

  1. Summary of ANOVA.