Table 6 Safety results that provide a posterior probability of 90% or more of observing a percentage of serious adverse events in the overall sample higher than an acceptable maximum (4%)

2

13 to 27

3

28 to 44

4

45 to 61

5

62 to 79

6

80 to 98

7

99 to 117

8

118 to 137

9

138 to 157

10

158 to 177

11

178 to 198

12

199 to 218

13

219 to 239

14

240 to 260

15

261 to 281

16

282 to 302

17

303 to 323

18

324 to 345

19

346 to 366

20

367 to 388

21

389 to 410

22

411 to 431

23

432 to 453

24

454 to 475

25

476 to 497

26

498 to 519

27

520 to 541

28

542 to 563

29

564 to 585

30

586 to 608

31

609 to 630

32

631 to 652

33

653 to 674

34

675 to 679