Hand washing with soap and water together with behavioural recommendations prevents infections in common work environment: an open cluster-randomized trial

Table 3 Outcome measures in different study periods.

OUTCOME MEASURE	INTERVENTION ARM	BEFORE THE PANDEMIC	DURING AND AFTER THE PANDEMIC	TOTAL FOLLOW-UP TIME
INFECTION EPISODES/REPORT WEEKS	IR1	0.096 (p = 0.002 vs. C)	0.097	0.097 (p = 0.04 vs. C)
	IR2	0.108	0.107	0.107
	CONTROL	0.115	0.098 (p = 0.005 vs. before pandemic)	0.104
RESPIRATORY INFECTION EPISODES/REPORT WEEKS	IR1	0.074 (p = 0.01 vs. C)	0.078	0.076
	IR2	0.084	0.085 (p = 0.03 vs. C)	0.085
	CONTROL	0.088	0.075	0.080
GASTROINTESSINAL INFECTION EPISODES/REPORT WEEKS	IR1	0.015	0.011	0.012 (p = 0.03 vs. C)
	IR2	0.017	0.015	0.016
	CONTROL	0.018	0.015	0.016
SICK LEAVE EPISODES/REPORT WEEKS	IR1	0.031	0.047	0.042
	IR2	0.027	0.039	0.035
	CONTROL	0.030	0.038 (p = 0.003 vs. IR1)	0.035 (p = 0.004 vs. IR1)
ABSENCE EPISODES/REPORT WEEKS	IR1	0.038	0.054	0.048
	IR2	0.036	0.050	0.045
	CONTROL	0.038	0.044 (p = 0.003 vs. IR1)	0.042 (p = 0.009 vs. IR1)

Numbers represent proportions calculated from the number of reported episodes in a trial arm per total reported weeks. Proportions can be converted to episodes per person year by multiplying by 52. Statistically significant differences indicating efficacy of the intervention are shown in bold face.

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