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Adaptive designs: current status, future outlook

The world of pharmaceutical statistics has taken adaptive designs to its heart - at least in theory. However despite the very large number of methodological publications and presentations at conferences there are still very few examples of adaptive designs in the medical literature. In this talk I will discuss why this might be the case and will suggest areas where these approaches are likely to be of greatest value in the future.

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Correspondence to Andy Grieve.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Grieve, A. Adaptive designs: current status, future outlook. Trials 12, A1 (2011).

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  • Public Health
  • Medical Literature
  • Future Outlook
  • Adaptive Design
  • Pharmaceutical Statistic


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