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Table 1 In vitro characterization of in situ formulation

From: A pseudo-randomised clinical trial of in situ gels of fluconazole for the treatment of oropharngeal candidiasis

Formu-ation

pH*

Viscosity*

(cps)

Spreadibility

g.cm/s

Drug Content

(%w/w)

*Muco-adhesive force

dynes/cm2

Gelling

Capacity

Gel strength

g/s

F1

7.2

14000

28.5

90.4

52.5 ± 7.5

+++

6.5

  1. * Average of three reading
  2. - No gelation; + Gel after few minutes, dissolved rapidly; ++ Gelation immediately, remains for few hours; +++ Gelation immediately, remains for extended period.
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Trials

ISSN: 1745-6215