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Table 4 Optic nerve-based measures in treatment group

From: The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments

  Clinically Affected
(mean, SD)
Clinically Unaffected
(mean, SD)
p
Number of optic nerves (n) 14 6  
LogMAR 0.15 (0.20) 0.15 (0.17) 0.9640
Sloan 25% 0.31 (0.26) 0.30 (0.20) 0.9746
Sloan 5% 0.66 (0.35) 0.53 (0.18) 0.4282
Sloan 1.25% 1.0 (0.46) 0.75 (0.15) 0.1544
FM-100 Square-Root Total Error Score 16.0 (4.4) 13.5 (2.8) 0.2188
Visual field Mean Deviance -4.28 (2.04) -3.04 (2.06) 0.2267
RNFL average thickness (microns) 72.4 (12.9) 85.5 (10.2) 0.0399
Macular volume (mm 3 ) 6.1 (0.5) 6.6 (0.3) 0.0624
Full field VER latency (milliseconds) 136.3 (15.2) 114.8 (7.1) 0.0045
Full-field VER amplitude (microvolts) 4.8 (1.9) 4.5 (2.3) 0.7669
Optic nerve area (mm 2 ) 8.1 (1.3) 8.9 (1.1) 0.1961
Optic nerve MTR (pu) 28.4 (2.9) 31.3 (2.3) 0.0515
Optic nerve DTI Mean Diffusivity (×10 -3 mm 2 /s) 1.17 (0.29) 1.25 (0.26) 0.5415
Optic nerve DTI Fractional Anisotropy (×10 3 ) 298.2 (91.2) 353.3 (88.6) 0.2282
Optic nerve DTI Radial Diffusivity (×10 -3 mm 2 /s) 0.99 (0.26) 1.03 (0.24) 0.7004
Optic nerve DTI Axial Diffusivity (×10 -3 mm 2 /s) 1.53 (0.42) 1.70 (0.35) 0.4012
  1. FM-100 = Farnsworth-Munsell 100-Hue test; RNFL = Retinal Nerve Fibre Layer; VER = Visual Evoked Response; DTI = Diffusion Tensor Imaging.