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Figure 1 | Trials

Figure 1

From: Sample size requirements for separating out the effects of combination treatments: Randomised controlled trials of combination therapy vs. standard treatment compared to factorial designs for patients with tuberculous meningitis

Figure 1

Power curves for 2 × 2 factorial designs without an interaction assuming a hazard ratio of combination treatment versus standard treatment of 0.7 and an overall mortality of 35%. Figure legend text: The black, dashed blue, and red lines correspond to the probability that the more potent individual treatment, at least one of the two treatments or both treatments jointly, respectively, reach statistical significance. The orange and green lines correspond to the probability of a significant difference between combination treatment and standard treatment in the factorial trial and in a 2-group trial of combination treatment versus standard treatment with equal sample size, respectively.

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Trials

ISSN: 1745-6215