Table 3 Endpoints
Primary endpoint | Infarct size measured as the final infarct size on delayed contrast enhancement (DCE) MRI at 4 months as a percentage of the area at risk on T2 weighted MRI at 3-7 days. |
|---|---|
Secondary endpoints | Myocardial salvage index and final infarct size measured by MRI |
Regional cardiac function based on echocardiographic and MRI segmental analysis at 2-7 days and at 4 months (for echo) and at 3-7 days and at 4 months (for MRI). | |
Global cardiac functional parameters measured by echocardiography and MRI | |
Myocardial infarct size as measured by serum CK-MB release during the first 72 hours after PCI. | |
Microvascular obstruction measured by DCE MRI 3-7 days after PCI. | |
Blood pressure and heart rate at 1 day, 7 days and at 4 months | |
The occurrence within 4 months of a Major Adverse Cardiac Event (MACE) defined as cardiac death, myocardial infarction, coronary bypass grafting, or a repeat PCI. | |
Repeat PCI in the infarct related artery during 4 months follow up. | |
Plasma glucose levels during the first 72 hours. | |
Side effects of exenatide | |
Angiographic parameters as Thrombolysis in Myocardial Infarction (TIMI) frame count and TIMI blush grade |