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Table 4 Risk of death or PD by center and treatment

From: Pre-referral rectal artesunate in severe malaria: flawed trial

Center

Artesunate (%)

Placebo (%)

RD (95% CI)

Africa-Handeni

54/726 (7.4%)

71/737 (9.6%)

2.2% (-0.8%, 5.2%)

Africa-Kilosa

27/1170 (2.3%)

31/1169 (2.7%)

0.3% (-1.0%, 1.7%)

Africa-Navrong

30/1145 (2.6%)

43/1093 (3.9%)

1.3% (-0.3%, 2.9%)

Bangladesh

45/3031 (1.5%)

45/2997 (1.5%)

0.1% (-0.6%, 0.7%)

Overall

156/6072 (2.6%)

190/5996 (3.2%)

0.6% (-0.3%, 1.4%) *

  1. Note: Due to lack of relevant data, these analyses are not ITT analysis. Instead, they use the subjects analyzed by Gomes et al. with death assessed by the day of the 7-30 day follow up; *Random effects model estimates.