Mean level at the end of treatment period | Mean difference (95% CI) | P-values | |||||
---|---|---|---|---|---|---|---|
N | Placebo | Rostafuroxin | Active minus placebo | Treatment effect | Carryover effect | Period effect | |
Sodium (μmol/min) | |||||||
Whole day | 386 | 122.3 ± 53.1 | 117.3 ± 50.4 | -5.1 (-10.5 to 0.4) | 0.071 | 0.546 | 0.256 |
Daytime | 386 | 128.2 ± 69.8 | 126.3 ± 86.7 | -1.9 (-10.9 to 7.0) | 0.672 | 0.802 | 0.880 |
Nighttime | 386 | 115.6 ± 87.4 | 107.6 ± 67.8 | -8.0 (-16.4 to 0.4) | 0.061 | 0.710 | 0.112 |
Potassium (μmol/min) | |||||||
Whole day | 386 | 43.7 ± 22.1 | 43.5 ± 20.2 | -0.2 (-2.6 to 2.2) | 0.844 | 0.942 | 0.685 |
Daytime | 386 | 49.5 ± 29.1 | 50.7 ± 38.4 | 1.2 (-2.8 to 5.2) | 0.545 | 0.641 | 0.320 |
Nighttime | 386 | 33.4 ± 27.3 | 32.3 ± 21.8 | -1.1 (-4.2 to 2.0) | 0.479 | 0.692 | 0.775 |
Sodium/potassium ratio | |||||||
Whole day | 386 | 2.84 (0.99 to 7.74) | 2.72 (0.96 to 8.13) | 0.96 (0.90 to 1.01) | 0.122 | 0.434 | 0.154 |
Daytime | 386 | 2.64 (0.81 to 8.29) | 2.53 (0.77 to 8.66) | 0.96 (0.90 to 1.02) | 0.196 | 0.490 | 0.273 |
Nighttime | 386 | 3.46 (1.03 to 10.6) | 3.34 (1.06 to 11.6) | 0.97 (0.90 to 1.04) | 0.327 | 0.093 | 0.314 |
Plasma ouabain (pmol/L) | 357 | 155.4 (56.8 to 453) | 161.6 (57.7 to 425.0) | 1.04 (0.98 to 1.10) | 0.192 | 0.997 | 0.369 |
Plasma renin activity (ng/mL/h) | 374 | 0.57 (0.11 to 2.62) | 0.57 (0.12 to 2.95) | 1.00 (0.94 to 1.07) | 0.948 | 0.087 | 0.672 |
Aldosterone excretion (nmol/24 h) | 334 | 25.7 (5.96 to 130) | 25.5(4.99 to 111) | 0.99(0.90 to 1.09) | 0.862 | 0.366 | 0.377 |