Table 1 Sample size estimates for the full cohort analysis; p denotes the proportion with a single genetic variant and Δ denotes the corresponding minimum detectable difference
| Â | Â | Standard Deviation of PTTR | |||||
|---|---|---|---|---|---|---|---|
| Â | Â | 20% | 25% | 30% | |||
| Â | Â | Power | Power | Power | |||
p | Δ | 80% | 90% | 80% | 90% | 80% | 90% |
0.4 | 5.49% | 550 | 730 | 860 | 1140 | 1238 | 1642 |
0.5 | 4.58% | 792 | 1050 | 1238 | 1642 | 1782 | 2364 |
0.6 | 3.67% | 1238 | 1642 | 1932 | 2564 | 2782 | 3692 |