Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison

Table 2 NSAIDS for acute pain[19].

Treatment Comparison	Mixed Treatment Comparison		Adjusted Indirect Comparison
	Odds Ratio	95% Credible Interval	Odds Ratio	95% Confidence Interval
Ketoprofen vs. Placebo	6.55	(4.35, 9.95)	6.06	(4.07, 9.04)
Ibuprofen vs. Placebo	2.95	(1.92, 4.57)	2.70	(1.78, 4.09)
Felbinac vs. Placebo	3.02	(2.01, 4.58)	2.91	(1.94, 4.39)
Piroxicam vs. Placebo	2.75	(1.86, 4.08)	2.65	(1.80, 3.90)
Indomethacin vs. Placebo	1.60	(0.99, 2.62)	1.58	(0.97, 2.57)
Other NSAID vs. Placebo	3.74	(2.73, 5.13)	3.31	(2.46, 4.45
Ibuprofen vs. Ketoprofen	0.45	(0.25, 0.81)	0.44	(0.25, 0.79)
Felbinac vs. Ketoprofen	0.46	(0.26, 0.83)	0.48	(0.27, 0.84)
Piroxicam vs. Ketoprofen	0.42	(0.24, 0.74)	0.43	(0.25, 0.76)
Indomethacin vs. Ketoprofen	0.24	(0.13, 0.46)	0.26	(0.13, 0.48)
Other NSAID vs. Ketoprofen	0.57	(0.34, 0.95)	0.54	(0.33, 0.89)
Felbinac vs. Ibuprofen	1.02	(0.56, 1.86)	1.07	(0.60, 1.92)
Piroxicam vs. Ibuprofen	0.93	(0.52, 1.67)	0.98	(0.55, 1.73)
Indomethacin vs. Ibuprofen	0.54	(0.29, 1.04)	0.58	(0.30, 1.11)
Other NSAID vs. Ibuprofen	1.27	(0.74, 2.15)	1.22	(0.73, 2.04)
Piroxicam vs. Felbinac	0.91	(0.52, 1.60)	0.91	(0.51, 1.59)
Indomethacin vs. Felbinac	0.53	(0.28, 1.01)	0.54	(0.28, 1.02)
Other NSAID vs. Felbinac	1.24	(0.74, 2.08)	1.13	(0.68, 1.88)
Indomethacin vs. Piroxicam	0.58	(0.31, 1.09)	0.59	(0.31, 1.11)
Other NSAID vs. Piroxicam	1.36	(0.82, 2.25)	1.24	(0.76, 2.03)
Other NSAID vs. Indomethacin	2.33	(1.31, 4.15)	2.09	(1.18, 3.70)

Bolded text denotes head-to-head meta-analysis evaluations. * Mixed treatment method identifies a significant effect, adjusted indirect comparison does not, adjusted indirect comparison identifies significant effect, mixed treatment comparison does not. ** Direction of effect differs between approaches, ***Important effect size differences.

ISSN: 1745-6215