Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression

Table 1 Covariates in the statistical models for the AGENDA trial.

Outcome	Primary outcome: AUC-total plasma cortisol	Secondary outcome Neuroticism	Secondary outcome Cognitive function	Tertiary outcomes
AUC-total plasma cortisol	x	x		x
Age	x	x	x	x
Gender	x	x	x	x
HAMD, entry	x		x	x
Body Mass Index, entry	x
Number of daily cigarettes	x
Danish Adult Reading Test			x
Years of education		x
Drug-level	x	x	x	x

ISSN: 1745-6215