| Median | Arms accruing at Activity Stage |  | Total | Differences b in | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Pts/yr | Median FFS (m) | Median OS (m) | 1 | 2 | 3 | 4 | Year accrual stopped | Pts | Time (m) | Total pts | Time (m) |
No arms stop early | |||||||||||
500 | 24 | 48 | 6 | 6 | 6 | 6 | Uncappedc | 3411 | 82 | 0 | 0 |
500 | 24 | 48 | 6 | 6 | 6 | 6 | 7 | 3411 | 82 | 0 | 0 |
500 | 24 | 48 | 6 | 6 | 6 | 6 | 6 | 3000 | 83 | -411 | 1 |
500 | 24 | 48 | 6 | 6 | 6 | 6 | 5 | 2500 | 89 | -911 | 7 |
One arm is dropped after each Activity Stage | |||||||||||
500 | 24 | 48 | 6 | 5 | 4 | 3 | Uncappedc | 3133 | 75 | 0 | 0 |
500 | 24 | 48 | 6 | 5 | 4 | 3 | 7 | 3133 | 75 | 0 | 0 |
500 | 24 | 48 | 6 | 5 | 4 | 3 | 6 | 3000 | 75 | -133 | 0 |
500 | 24 | 48 | 6 | 5 | 4 | 3 | 5 | 2500 | 80 | -633 | 5 |
Dropped to 2 arms after Activity Stage I | |||||||||||
500 | 24 | 48 | 6 | 2 | 2 | 2 | Uncappedc | 2738 | 66 | 0 | 0 |
500 | 24 | 48 | 6 | 2 | 2 | 2 | 7c | 2738 | 66 | 0 | 0 |
500 | 24 | 48 | 6 | 2 | 2 | 2 | 6 | 2738 | 66 | 0 | 0 |
500 | 24 | 48 | 6 | 2 | 2 | 2 | 5 | 2500 | 66 | -162 | 0 |
Dropped to 2 arms after Activity Stage II | |||||||||||
500 | 24 | 48 | 6 | 6 | 2 | 2 | Uncappedc | 2983 | 72 | 0 | 0 |
500 | 24 | 48 | 6 | 6 | 2 | 2 | 7c | 2983 | 72 | 0 | 0 |
500 | 24 | 48 | 6 | 6 | 2 | 2 | 6 | 2983 | 72 | 0 | 0 |
500 | 24 | 48 | 6 | 6 | 2 | 2 | 5 | 2500 | 75 | -483 | 3 |
One arm dropped after each Activity Stage & survival is longer | |||||||||||
500 | 24 | 60 | 6 | 5 | 4 | 3 | Uncapped | 3397 | 82 | 0 | 0 |
500 | 24 | 60 | 6 | 5 | 4 | 3 | 7c | 3397 | 82 | 0 | 0 |
500 | 24 | 60 | 6 | 5 | 4 | 3 | 6 | 3000 | 83 | -397 | 1 |
500 | 24 | 60 | 6 | 5 | 4 | 3 | 5 | 2500 | 91 | 897 | 91 |
One arm is dropped after each Activity Stage & accrual is slower | |||||||||||
350 | 24 | 48 | 6 | 5 | 4 | 3 | Uncapped | 2702 | 93 | 0 | 0 |
350 | 24 | 48 | 6 | 5 | 4 | 3 | 7 | 2450 | 94 | -252 | 1 |
350 | 24 | 48 | 6 | 5 | 4 | 3 | 6 | 2100 | 101 | -602 | 8 |
350 | 24 | 48 | 6 | 5 | 4 | 3 | 5a | n/a | n/a | n/a | n/a |