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Table 2 Guidelines for stopping accrual to the ith research arm at intermediate analyses

From: Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trial

Activity Stage

Timing of analysis: control arm events

Critical value

(Hazard Ratio)

I

114

1·00

II

215

0·92

III

334

0·89

  1. The intermediate analyses are timed according to the number of events reports on the control arm. Discontinuation of recruitment to a research arm will be considered if the observed hazard ratio is greater than the critical value (also known as the critical cutpoint or "hurdle")
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Trials

ISSN: 1745-6215