Table 9 FOCUS results of final analysis after early stopping at stage 1.
one-sided sig. level | A vs B | A vs C | A vs D | A vs E | Power for | ||||
|---|---|---|---|---|---|---|---|---|---|
at recruitment stop | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | final analysis |
0.5 | 0.93 | (0.76–1.13) | 0.88 | (0.72–1.08) | 0.96 | (0.78–1.17) | 1.03 | (0.85–1.26) | 90% |
0.4 | 0.94 | (0.78–1.14) | 0.87 | (0.72–1.05) | 0.97 | (0.81–1.18) | 1.04 | (0.86–1.25) | > 90% |
0.3 | 0.89 | (0.74–1.06) | 0.88 | (0.73–1.05) | 0.94 | (0.79–1.13) | 0.97 | (0.81–1.16) | > 90% |
0.2 | 0.92 | (0.77–1.09) | 0.93 | (0.78–1.10) | 0.99 | (0.84–1.17) | 1.03 | (0.87–1.22) | > 90% |
0.1 | 0.89 | (0.76–1.04) | 0.86 | (0.73–1.00) | 0.99 | (0.85–1.15) | 0.97 | (0.83–1.13) | > 90% |
n/a – actual analysis | 0.91 | (0.81–1.06) | 0.84 | (0.73–0.96) | 0.97 | (0.85–1.11) | 0.93 | (0.81–1.06) | n/a |