Table 8 Re-analysis over two stages of trials with final result showing no evidence of a difference using overall survival as intermediate endpoint.

A vs B

A vs D

A vs E

one-sided sig.

e _I

%

ρ

time

e _I

%

ρ

%

ρ

%

ρ

mean time

level at stage 1

err.

saved (yrs)

Err.

err.

err.

saved (yrs)

0.5

116

61.44

0.31

1.89

97

68.32

0.31

82.34

0.36

43.04

0.27

1.51

0.4

152

42.44

0.36

1.67

125

58.32

0.36

81.5

0.39

50.88

0.29

1.32

0.3

194

45.4

0.41

1.48

161

56.92

0.40

90.82

0.43

57.76

0.35

1.07

0.2

250

56.46

0.47

1.25

206

77.98

0.43

88.08

0.50

34.96

0.40

0.83

0.1

339

52.56

0.54

0.83

280

35.4

0.52

44.44

0.62

16.98

0.50

0.34