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Table 8 Re-analysis over two stages of trials with final result showing no evidence of a difference using overall survival as intermediate endpoint.

From: How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials

  ICON3 FOCUS
      A vs B    A vs D   A vs E   
one-sided sig. e I % ρ time e I % ρ % ρ % ρ mean time
level at stage 1   err.   saved (yrs)   Err.   err.   err.   saved (yrs)
0.5 116 61.44 0.31 1.89 97 68.32 0.31 82.34 0.36 43.04 0.27 1.51
0.4 152 42.44 0.36 1.67 125 58.32 0.36 81.5 0.39 50.88 0.29 1.32
0.3 194 45.4 0.41 1.48 161 56.92 0.40 90.82 0.43 57.76 0.35 1.07
0.2 250 56.46 0.47 1.25 206 77.98 0.43 88.08 0.50 34.96 0.40 0.83
0.1 339 52.56 0.54 0.83 280 35.4 0.52 44.44 0.62 16.98 0.50 0.34
  1. For details see legend of table 5
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