Table 7 Re-analysis over two stages of trials with final result showing evidence of a difference using overall survival as intermediate endpoint.

one-sided sig.

e _I

%

ρ

e _I

%

ρ

e _I

%

ρ

level at stage 1

err.

err.

err.

0.5

75

0.0

0.32

53

6.32

0.44

97

9.42

0.28

0.4

97

0.0

0.46

69

3.84

0.50

125

8.4

0.30

0.3

125

0.0

0.56

88

0.62

0.57

161

32.54

0.38

0.2

162

0.0

0.70

114

0.68

0.68

206

15.44

0.42

0.1

221

0.1

0.76

155

0.04

0.88

280

16.12

0.50