Skip to main content

Table 7 Re-analysis over two stages of trials with final result showing evidence of a difference using overall survival as intermediate endpoint.

From: How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials

  ICON4 RE01 FOCUS: A vs C
one-sided sig. e I % ρ e I % ρ e I % ρ
level at stage 1   err.    err.    err.  
0.5 75 0.0 0.32 53 6.32 0.44 97 9.42 0.28
0.4 97 0.0 0.46 69 3.84 0.50 125 8.4 0.30
0.3 125 0.0 0.56 88 0.62 0.57 161 32.54 0.38
0.2 162 0.0 0.70 114 0.68 0.68 206 15.44 0.42
0.1 221 0.1 0.76 155 0.04 0.88 280 16.12 0.50
  1. For details see legend of table 5.
\