Using discrete choice experiments to inform the design of complex interventions

Background Complex health interventions must incorporate user preferences to maximize their potential effectiveness. Discrete choice experiments (DCEs) quantify the strength of user preferences and identify preference heterogeneity across users. We present the process of using a DCE to supplement conventional qualitative formative research in the design of a demand creation intervention for voluntary medical male circumcision (VMMC) to prevent HIV in Tanzania. Methods The VMMC intervention was designed within a 3-month formative phase. In-depth interviews (n = 30) and participatory group discussions (n = 20) sought to identify broad setting-specific barriers to and facilitators of VMMC among adult men. Qualitative results informed the DCE development, identifying the role of female partners, service providers’ attitudes and social stigma. A DCE among 325 men in Njombe and Tabora, Tanzania, subsequently measured preferences for modifiable VMMC service characteristics. The final VMMC demand creation intervention design drew jointly on the qualitative and DCE findings. Results While the qualitative research informed the community mobilization intervention, the DCE guided the specific VMMC service configuration. The significant positive utilities (u) for availability of partner counselling (u = 0.43, p < 0.01) and age-separated waiting areas (u = 0.21, p < 0.05) led to the provision of community information booths for partners and provision of age-separated waiting areas. The strong disutility of female healthcare providers (u = − 0.24, p < 0.01) led to re-training all providers on client-friendliness. Conclusion This is, to our knowledge, the first study documenting how user preferences from DCEs can directly inform the design of a complex intervention. The use of DCEs as formative research may help increase user uptake and adherence to complex interventions. Electronic supplementary material The online version of this article (10.1186/s13063-019-3186-x) contains supplementary material, which is available to authorized users.


Background
User social and behavioural characteristics can attenuate the effectiveness of complex interventions, which exacerbates the challenge of testing their effectiveness in trials. For example, use of antiretroviral (ART)-based vaginal and oral pre-exposure prophylaxis (PrEP) was effective in five of eight randomized controlled trials (RCTs) [1][2][3][4][5][6][7][8], with the differing results largely attributed to sub-optimal adherence rather than a lack of product efficacy [9,10].
Incorporating user preferences at the intervention design phase may be useful for enhancing the uptake of and adherence to complex health interventions.
Although there is a growing literature reporting on the formative research processes applied in intervention development [11][12][13][14][15], to date only few studies or theoretical frameworks provide methodological guidance on conducting such formative research [16][17][18]. Qualitative research can identify a range of barriers and facilitators of accessing services, and participatory rating or ranking exercises can retrieve ordinal measures of importance. However, when faced with numerous service characteristics and a need to prioritize between them, neither of these approaches provides concrete guidance for implementers on which combination of characteristics will achieve the greatest uptake. Some studies have used discrete choice experiments (DCEs) to inform programme design and identify potential barriers and facilitators of uptake [19][20][21]. DCEs are a survey-based approach to eliciting user preferences. They allow the estimation of user values in the absence of observable markets, where services are provided for free or have not yet been introduced. They can measure the strength of preferences between service attributes, for example, valuing waiting times, prices and provider gender, independently. Lastly, they can identify where preferences differ between individuals, which is particularly useful when complex interventions include targeting specific user groups.
The purpose of this study is to describe how the DCE methodology can be used to inform the development of complex interventions. To demonstrate the approach, we use the case of an intervention to increase uptake of voluntary medical male circumcision (VMMC) among adult men in Tanzania (Table 1), for which the DCE was integral in prioritizing the intervention components. We argue that this may be a useful addition to the current MRC guidelines for developing and evaluating complex interventions [21], as proposed in Fig. 1.

Methods
We present the mixed-methods formative research in chronological order. First, the conventional formative qualitative research is described. We then present the design of the DCE and how it built on this qualitative work, followed by the methods for DCE data collection and analysis. Finally, we discuss the intervention design features resulting from information generated within the conventional formative research and the contribution of a DCE in this complex intervention.
Designing an evidence-based demand creation intervention: integrated formative data collection The DCE was integrated into the qualitative data collection activities. Table 2 presents an overview of the fieldwork process and how the qualitative research and DCEs were conducted in tandem. While the qualitative research team undertook in-depth interviews (IDIs) and participatory group discussions (PGDs), real-time debriefing of qualitative field teams provided qualitative insights for the DCEs. The qualitative team conducted additional iterative cognitive interviews while the DCE tools were developed and subsequently administered the DCE questionnaires. Recruitment for this phase is described in detail in Additional file 1.

Conventional formative research
Following a scoping literature review around behaviour change and VMMC, the information-motivation-behavioural (IMB) theory was chosen as the most suitable behaviour change framework [22]. Gaps were identified and formative research underpinning the IMB theory was conducted to identify individual and community-level factors that facilitate or limit the uptake of VMMC in each of the three constructs. Findings from this formative research were used to develop the intervention that was evaluated in phase 2 of the study and have been published elsewhere Table 1 Voluntary medical male circumcision demand creation intervention in Tanzania Following strong evidence for the effectiveness of voluntary medical male circumcision (VMMC) in reducing men's risk of acquiring HIV, Tanzania was identified as one of 14 high-priority countries for VMMC scale-up [37]. Tanzania, which started rolling out VMMC in 2009, has a national adult HIV prevalence of 5.0% [38] and an adult male circumcision prevalence of 72% [39,40]. The Tanzanian HIV and AIDS Strategic Plan prioritized scaling-up VMMC to males aged 10-34 years in eight regions (which was later increased to 12 regions due to administrative divisions), including Njombe and Tabora [41]. The National AIDS Control Programme established a target of circumcising 2.2 million eligible males aged 10-34 years in these 12 regions [40]. Significant progress has been made towards these targets: from 2009 to 2015, almost 1.2 million VMMCs were performed in the priority regions [42].
VMMC in Tanzania has predominantly attracted a young male population: As of 2012, 82% of VMMC clients in Njombe and Iringa were adolecent boys between 10-19 years old [43]. For a more immediate impact on HIV incidence, reaching an older, sexually active but not yet HIV-infected client base would be preferable. Social barriers in relation to adult men accessing VMMC services have been documented in Tanzania [44,45]. To evaluate a model of demand creation and service delivery to increase uptake of VMMC among adult men aged ≥ 20 years, a two-phase study was implemented in the Tabora and Njombe regions. Njombe is the region with the highest HIV prevalence at 14.8% [46], and Tabora has a prevalence of 6.4%, which is higher than the national average (5.1%) [47]. In 2012, male circumcision coverage was 49% in Njombe and in Tabora, which is considerably lower than the national average of 72% [47]. Phase 1 of the study consisted of formative research to develop a package of demand creation activities designed to increase the client base of adult men (age 20-34 years).
Phase 2 was a cluster randomized trial evaluating the impact of the developed complex demand-creation intervention with a goal of increasing the proportion and number of VMMC clients aged 20-34 years whose results are published [33]. In brief, 20 outreach sites in Njombe and Tabora were randomized to receive either a demand-creation intervention package (described in Table 4) plus standard VMMC outreach, or standard VMMC outreach only. The primary outcome was defined as the increase in the proportion of 20-34 year olds among all men being circumcised in the intervention arm. Secondary outcomes compared the total increased uptake compared to the routine VMMC strategy, as well as uptake among all mature men (age ≥ 20 years).

Intervention evaluation
The RCT showed significant increases in VMMC uptake across men of all ages relative to the control arm (619 versus 393, p = 0.03) [33]. In Tabora there was a significant increase in the proportion of men aged 20-34 years (28% in the intervention arm relative to 12% in the control arm; p < 0.00), but not in Njombe (11% in the intervention arm and 15% the control arm; p = 0.44) where large increases among the younger men were also observed [33]. Further details of the intervention and its evaluation can be found in Wambura et al. [33]. [23]. In brief, the qualitative research team conducted 30 in-depth interviews and 20 participatory group discussions across the two regions, Njombe and Tabora, in rural and urban areas, with women and with younger men (age < 20 years) and older men (age 20 years and older). These interviews aimed to comprehensively understand barriers and facilitators to access VMMC services. When the DCE was added, the scope was expanded to determine which service delivery components to assess within the DCE and thus informed the early stages of the DCE, following the DCE guidelines [24].

The discrete choice experiment
DCEs present respondents with a series of choice scenarios where they are asked to choose between two or more alternative goods or services with simultaneously varying attribute levels (Fig. 2). In making these choices, respondents are forced to trade-off between preferred and less preferred attribute levels presented in each alternative service. Econometric analysis of respondent choices allows one to retrieve the value (utility) derived from each attribute level relative to the others. It can also test whether people with different characteristics, such as age and gender, have significantly different preferences.
Using the estimated utilities of goods (i.e. the sum of the utility of each characteristic), one can estimate relative market shares. If an opt-out alternative is included (i.e. one can choose 'Neither of the alternatives'), levels of uptake can be predicted. As such, DCEs allow one to explore the impact of varying service characteristics on potential uptake of an intervention in the context of both research and programme implementation [25].
The development of the DCE followed steps as laid out in the standard guidelines [24]. The literature on the uptake of VMMC among adult men (age 20 years and   older), including the grey literature of qualitative work from within Tanzania, was reviewed [26,27]. Following this, the DCE was developed and implemented over a 6-week period of fieldwork (February-March 2014). Potential feasible demand creation strategies were explored using sequential rounds of cognitive interviews and debriefings from two group discussions considering both the key drivers of demand and their pictorial representations.
The final attributes (including pictorial representations) included in the DCE are shown in Fig. 2. The full set of attribute levels are presented in Table 3. The DCE provided participants with a sequence of nine repeated choices between two generic circumcision services and 'Neither'. For uncircumcised men, 'Neither' represented remaining uncircumcised; for circumcised men, 'Neither' represented having the same services they had when previously circumcised. Analysis of a pilot DCE survey (n = 54) provided the priors to generated a d-efficient design using NGENE 1.1 [28]. The DCE design allowed for an analysis capturing the preference heterogeneity for service characteristics by region (Tabora and Njombe), age and circumcision status. Although preferences for financial incentives were also collected, they were not considered an option within this intervention package and were therefore not part of the intervention development process.

Statistical methods
The utility of a given service (VMMC A or VMMC B ) is estimated as a function of the utilities of the separate service characteristics: These service characteristics varied in each choice scenario, as determined in the experimental design. Respondents could also choose to not be circumcised in either VMMC A or VMMC B and then choose 'Neither' , which in the first instance is given an alternative specific constant (ASC). To obtain total utility for a given service, one can sum the utility values of the specified attribute levels.
Service attributes and respondent covariates allow for exploration of observed preference heterogeneity and will be indicated as the multinomial logit model with interactions (MNLX). In this case we allowed for variation by respondents' region (Tabora/Njombe, with _NJO indicating variation in preferences of those living in Njombe relative to Tabora) and age (< 21 years, ≥ 21 years). 1 Categorical variables were coded using effects coding (e.g. 1 and − 1 for a dichotomous variable), which imposes a central utility of 0; thus, the utilities represent relative preferences [29]. The magnitude of the utilities themselves has no meaning if not interpreted relative to the magnitude of utilities of other attributes. The significance levels of the utilities test whether the utilities are significantly different from the utility of the reference (i.e. the omitted) category.
Using the multinomial logit model (MNL) and to allow for unobserved preference heterogeneity and explore scale heterogeneity, we applied the generalized multinomial logit model (GMXL) estimator [30]. The gamma coefficient tests for unobserved preference heterogeneity and the tau coefficient tests for scale heterogeneity. If there is no scale heterogeneity, then the model can be collapsed to a random parameters logit model. Where there is neither scale nor unobserved heterogeneity, the model can be collapsed to the multinomial logit model. Estimation was undertaken using NLOGIT 5.0 [31]. The GMXL model parameters were obtained by simulation; 500 iterations using Halton draws were applied. Service configuration attribute parameters were specified as random with normal distributions. The incentives (lottery and transport The expected values of the low and high incentives are equal across the transport voucher and lottery reimbursement) were specified with a triangular distribution, as is common around price attributes to impose a minimum of 0 [32].

Intervention design
Following the qualitative and DCE analyses, a teleconference was held with the full project team to review the findings and revise the initial intervention design for implementation and to evaluate the tailored intervention with routine demand creation for VMMC within a cluster randomized controlled trial (CRT). This CRT is described in detail by Wambura et al. [33].

DCE sample description and analysis
The fieldwork team administered 325 DCE surveys, 159 in Njombe and 166 in Tabora, with approximately equal numbers in urban and rural areas. Participants' background characteristics are presented in Additional file 2. To sum, Christianity is the main religion among participants from Njombe (96%), with participants from Tabora having more diverse religious backgrounds: 51% Christian, 24% Muslim and 25% other religions. Ethnic composition was different between the regions: Bena participants were the majority in Njombe (83%), while in Tabora participants were primarily Sukuma (55%) and Nyamwezi (36%). Education and wealth (based on mobile phone and land ownership) appear similar across regions. Sexual behaviour appears more risky among participants from Tabora than from Njombe, with 51.3% and 38.6% (p ≤ 0.01), respectively, reporting more than one partner in the past year and 38.6% versus 50.4% (p < 0.01), respectively, reported condom use at last sex act. Only a third of participants self-reported not being circumcised, with similar rates across the regions. Knowledge and attitudes around VMMC also appear relatively similar across regions.
Full estimation results are presented in Additional file 3; it can be seen that relative utilities were largely robust across estimators. From here onwards we focus on the estimated utilities generated from the MNLX estimator, which estimates the main effects (i.e. those of the service attributes) and tests for preference heterogeneity by region and age, our key interest. Figure 3 shows the relative strength of preferences and the significant differences in preferences across regions and circumcision status. Where preferences did not significantly differ between region or circumcision status, they are not shown, but full utility estimates are presented in Additional file 3.
On average, availability of VMMC services outside standard working hours was not a significant driver of choice. All men preferred to have waiting areas that were separated by age (u = 0.21, p < 0.05). There was a relatively strong dislike for removing HIV testing from the VMMC process (u = − 0.40, p < 0.01). The service characteristic with the greatest utility was partner counselling (u = 0.43, p < 0.01), informing female partners of the need for post-operative abstinence and wound care, and was strongest among men in Tabora (u = 0.47, p < 0.05). Male-only service providers were preferred (u = 0.15, p < 0.1), with men in Njombe having four times stronger preferences for all-male service providers than men in Tabora (u Njombe = 0.15 + 0.09 = 0.24; u Tabora = 0.151-0.09 = 0.06).

The final intervention design
Following analysis of the formative research, results from both the DCE and the qualitative study were presented to the full project team for translation into a research design. The qualitative research largely informed community mobilization messaging, and the DCE largely informed the VMMC service delivery model in the intervention arm.

DCE influence on intervention design Time of service
Previously, it was known that mature men had challenges with fitting in VMMC alongside their livelihoods. It was thought that providing weekend or evening services may alleviate the latter. The DCE shows that this was unlikely to be a driving factor. During the campaign, communities were informed that evening VMMC services were available upon request, but evening services were otherwise not routinely provided.

Service separation
The strong and positive preference for a VMMC service providing separated waiting areas prompted setting up separate waiting areas for adolescents and adult men, particularly ensuring that the waiting areas were out of view of each other. It has not been previously recognized how strongly men of all ages felt about their privacy relative to other VMMC clients.

HIV testing
Some men had expressed reluctance to present for VMMC due to the HIV testing requirement. The positive value men place on the availability of HIV testing suggested that HIV testing was valued, and led the programme to maintain HIV testing as part of routine client flow and include it in the provider training to re-emphasize its voluntary nature to clients. If strong preferences had been identified against testing, alternative client flows would have been explored, where testing would not be the default.

Gender of service provider
The DCE highlighted how strongly uncomfortable men felt with female staff. It was not feasible to increase male providers. The mobile VMMC service relied on the public health system's supply of healthcare workers and was unable to influence the gender of providers supplied. However, re-training of providers emphasized the importance of professionalism in VMMC provision, and this was relayed in the community campaign.

Partner counselling
The qualitative research identified women as important influences on men's circumcision decisions [23]. The DCE pre-evaluated one option of addressing this: providing counselling and information to partners about the importance of post-natal abstinence and post-operative care. This was highly valued in the DCE and then implemented by setting up information booths in the community for women.

Intervention and evaluation
Wambura et al. [33] summarize the new intervention and the status quo/control arm against which it was evaluated, highlighting how the findings from the DCE fed into the intervention arm services ( Table 4). The new complex intervention focused on targeted demand creation among adult men (age 20-34 years) with a mass-media campaign and reconfigured services. Using trucks with mega-phones in the communities, radio spots, flyers and posters, and local community peer educators, communities received the key intervention messages. The community was informed about the highly trained staff, addressing issues related to perceptions around female staff and professional staff, and the availability of community-based information booths for female partners. Local peer educators also encouraged men to present for VMMC. Partner counselling booths were set up in the community where women could get information on post-operative abstinence and care. While not operationally feasible to engage all male service providers, re-training was undertaken to ensure

Discussion
This paper presents how DCEs can complement conventional qualitative research to prioritize service components most critical to the target population of adult men in Tanzania. The DCE results led to the inclusion of two key service components. Firstly, the strong preferences among both the younger men and the older men revealed the importance of age-separated waiting areas at the VMMC facilities. Waiting areas for VMMC were rearranged to allow for younger and older men to wait separately and out of view of each other. Secondly, the strong preference for partner counselling led to the introduction of partner counselling booths, staffed by both female health workers and female community peers who provided one-on-one and small group information for female partners about circumcision care and post-circumcision abstinence. Out-of-hours service provision was preferred in Njombe, but the utility was relatively small compared with the value placed on separated waiting areas and partner counselling service. This allowed the intervention to focus less effort on promoting out-of-hours VMMC services, although they remained available upon request. The suggested preference for opt-out testing led to an intensification of the information campaign, ensuring clients were comfortable requesting not to be tested for HIV and staff were re-trained to emphasize the right to opt-out of HIV testing to clients. Officially, however, both the intervention and the control arms maintained a policy of opt-out HIV testing.
DCEs have great potential to inform the design of complex interventions. DCEs can indicate the relative strength of preferences and identify differences in preferences between population groups, which suggest relative differences in uptake by composition of the intervention package. This paper adds to the literature on methods for the formative phase of complex interventions. The DCE's contribution is in estimating the relative strength of preferences for intervention components, where DCEs can help distinguish the relative importance to users of various intervention elements that had previously been combined as a package. In doing so, it can inform the optimal composition of interventions to maximize uptake.
The development of this VMMC intervention was informed both by traditional qualitative research and complemented by a DCE. Qualitative research led to the development of targeted messages and appropriate community engagement approaches, while the DCE identified priority service attributes for inclusion and highlighted, in particular, the importance adult men placed on separate waiting areas for adolescent and adult males.
The integrated approach to DCE implementation had a few limitations. As the DCE had to fit into the pre-established formative phase timelines, it did not allow for theory-based qualitative analysis to be finalized to inform the DCE design. In this case, there was a reasonably large qualitative literature on men's preferences for VMMC in Tanzania; thus, this is unlikely to have undermined the identification of appropriate attributes and levels. In future applications, it is recommended to allow for additional time between the qualitative formative work and the DCE implementation to ensure the DCE is fully informed by robust qualitative analysis. In retrospect, sampling of younger men would have augmented the understanding of how preferences may be different between adolescent men and adult men. This was recognized, but including men younger than 18 years old would have required parental consent, and was considered not feasible within the formative research timeline. Although our main objective was to increase Incentives were not considered as part of this intervention and were purely included in the DCE for exploratory analysis uptake among mature men, it appears that the service configuration changes, like separate waiting areas, were preferred both by younger and older men, as suggested by the large increases in uptake among all age groups. Lastly, the decision to be circumcised is only relevant to uncircumcised men, but to recruit only uncircumcised men would have added costs and time, potentially introducing response bias. Nevertheless, our results appear to have informed the development of a highly effective intervention. However, uptake is only one part of intervention effectiveness, and the ultimate intervention impact is an interaction between efficacy and use. To model intervention impact using DCE uptake predictions, as proposed by Terris-Prestholt et al. [34], HIV risk profiles should be collected and sub-analysis by risk profile undertaken; this could only be done with more robust sample sizes.
There are a number of feasibility issues related to incorporating DCEs into the design phase of pragmatic trials and complex interventions. Firstly, the time required to collect and analyse DCE data can be long, limiting the extent to which this method can rapidly inform interventions. Secondly, DCEs require funding in addition to the primary research study, which may be difficult to justify without providing evidence of its usefulness in modifying the design of the intervention to maximize uptake. Although in this case study the programmers found that the DCE provided concrete design recommendations, how strongly different the intervention would otherwise have been with solely qualitative formative research, or the impact of it on the uptake, would need to be tested. This could follow a research design similar to that by Tang et al. which tested the best crowd-sourced HIV testing promotional videos against the conventionally used promotional video [35]. They found crowd-sourcing a cheaper and no less effective approach to designing these demand creation videos. Similarly, one might test the impact of a DCE-informed demand creation intervention against one developed solely based on qualitative formative research, and compare the costs as well as the uptake across the intervention and control arms.
Although all relevant drivers of demand must be included in DCE scenarios, some of these may not be modifiable for pragmatic reasons. Measuring preferences for non-modifiable attributes may still be critical for identifying key bottlenecks to use and for longer-term health system planning, although they may not be useful for designing shorter-term interventions within health system constraints. For example, ' All male service providers' was identified as very important but was not feasible in the short term due to structural shortages of male service providers. However, identification of important but unchangeable service characteristics can help interpret results in cases where a trial shows no impact, and are recommended to still be included in the DCE.
This study suggests two key areas for future research. Firstly, although this study did not include a process evaluation to better understand how the intervention components affected uptake during the trial, we do recommend this for future studies to further develop the use of DCEs for intervention design and to test the validity of the DCE predictions. Secondly, we need to estimate the cost-effectiveness of DCEs in complex intervention design. If trials fail to show the effectiveness of efficacious new technologies due to intervention delivery approaches, up-front investment in the delivery intervention could be a highly efficient use of resources. One approach to investigating whether uptake could significantly change an intervention's impact would be to apply a value-of-information analysis in the early intervention development stage. This models how important the uptake parameter is in an intervention's cost-effectiveness and how likely it would be in changing resource allocation decisions. If uptake is found critical, then a DCE may be more worth undertaking prior to complex intervention trials. An additional logical extension would be to use the DCE estimates to model the changes in uptake caused by modifying services. Task-shifting activities to lower healthcare worker grades who may technically perform the procedure equally well, for example, may appear as an appropriate cost saver, but the impact on the uptake is often unknown. DCEs can provide insights into the implications of changes, and when coupled with service component costs can look at the incremental cost-effectiveness of varying service components [34].

Conclusion
This paper has shown how DCEs may have ultimately contributed to a more effective intervention design. DCEs provide an important complement to the methodologies for developing complex interventions. For this application, the relative strength of preferences contributed to prioritization of the components of the complex intervention. DCEs can provide quantitative guidance on how to maximize uptake of interventions, in both simple and complex interventions, and may improve the quality of intervention research and implementation.

Availability of data and materials
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Authors' contributions FT-P, NN, JMG, MP, EK, HO, JJO, GM, HM, HAW and MW made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data. FT-P, MP, JMG, EK, JJO, JDT, HO and HAW were involved in drafting the manuscript or revising it critically for important intellectual content. FT-P, NN, JMG, MP, EK, HO, JJO, JDT, GM, HM, HAW and MW gave final approval of the version to be published. Each author participated sufficiently in the work to take public responsibility for appropriate portions of the content, and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Ethics approval and consent to participate
The study was granted ethical approval by the National Research Ethics committee in Tanzania (reference number NIMR/HQ/R.8a/Vol.IX/1661) and the Ethics Committees of the London School of Hygiene and Tropical Medicine (reference number 6238-02) and the US Centers for Disease Control and Prevention (reference number 6474). All study participants provided either signed or thumbprint (for those could not read or write) consent.

Consent for publication
Not applicable.