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  1. Distraction osteogenesis is the standard treatment for the management of lower limb length discrepancy of more than 3 cm and bone loss secondary to congenital anomalies, trauma or infection. This technique con...

    Authors: Reggie C Hamdy, Kathleen Montpetit, Joanne Ruck-Gibis, Kelly Thorstad, Ellen Raney, Michael Aiona, Robert Platt, Allen Finley, William Mackenzie, James McCarthy and Unni Narayanan

    Citation: Trials 2007 8:27

    Content type: Study protocol

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  2. Diabetes Mellitus constitutes one of the most important public health problems due to its high prevalence and enormous social and economic consequences. Diabetic foot ulcers are one of the chronic complication...

    Authors: Sandra Y Silva, Ligia C Rueda, Gustavo A Márquez, Marcos López, Daniel J Smith, Carlos A Calderón, Juan C Castillo, Jaime Matute, Christian F Rueda-Clausen, Arturo Orduz, Federico A Silva, Piyaporn Kampeerapappun, Mahesh Bhide and Patricio López-Jaramillo

    Citation: Trials 2007 8:26

    Content type: Study protocol

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  3. Mortality rates in the Intensive Care Unit and subsequent hospital mortality rates in the UK remain high. Infections in Intensive Care are associated with a 2–3 times increased risk of death. It is thought tha...

    Authors: Peter JD Andrews, Alison Avenell, David W Noble, Marion K Campbell, Claire G Battison, Bernard L Croal, William G Simpson, John Norrie, Luke D Vale, Jonathon Cook, Robyn de Verteuil and Anne C Milne

    Citation: Trials 2007 8:25

    Content type: Study protocol

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  4. In orthodontic treatment, anchorage control is a fundamental aspect. Usually conventional mechanism for orthodontic anchorage control can be either extraoral or intraoral that is headgear or intermaxillary ela...

    Authors: Britta A Jung, Heinrich Wehrbein, Werner Hopfenmüller, Winfried Harzer, Tomasz Gedrange, Peter Diedrich and Martin Kunkel

    Citation: Trials 2007 8:24

    Content type: Study protocol

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  5. Despite a burgeoning interest in using interprofessional approaches to promote effective collaboration in health care, systematic reviews find scant evidence of benefit. This protocol describes the first clust...

    Authors: Merrick Zwarenstein, Scott Reeves, Ann Russell, Chris Kenaszchuk, Lesley Gotlib Conn, Karen-Lee Miller, Lorelei Lingard and Kevin E Thorpe

    Citation: Trials 2007 8:23

    Content type: Study protocol

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  6. Secondary hyperparathyroidism (sHPT) is common in patients with chronic renal failure. Despite the initiation of new therapeutic agents, several patients will require parathyroidectomy (PTX). Total PTX with au...

    Authors: Katja Schlosser, Johannes A Veit, Stefan Witte, Emilio Domínguez Fernández, Norbert Victor, Hans-Peter Knaebel, Christoph M Seiler and Matthias Rothmund

    Citation: Trials 2007 8:22

    Content type: Study protocol

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  7. Despite the high cardiovascular risk, evidence of efficacy of preventive strategies in individuals with diabetes is scant. In particular, recommendations on the use of aspirin in patients with diabetes mostly ...

    Authors: Giorgia De Berardis, Michele Sacco, Virgilio Evangelista, Alessandro Filippi, Carlo B Giorda, Gianni Tognoni, Umberto Valentini and Antonio Nicolucci

    Citation: Trials 2007 8:21

    Content type: Study protocol

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  8. Patients with end stage liver disease are characteristically malnourished which is associated with poor outcome. Formulas enriched with arginine, ω-3 fatty acids, and nucleotides, "immunonutrients", potentiall...

    Authors: Arash Nickkholgh, Heinz Schneider, Jens Encke, Markus W Büchler, Jan Schmidt and Peter Schemmer

    Citation: Trials 2007 8:20

    Content type: Study protocol

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  9. Dysphagia occurs in up to 50% of patients admitted to hospital with acute strokes with up to 27% remaining by seven days. Up to 8% continue to have swallowing problems six months after their stroke with 1.7% s...

    Authors: Jessica R Beavan, Simon Conroy, Jo Leonardi-Bee, Tim Bowling, Catherine Gaynor, John Gladman, Dawn Good, Peter Gorman, Rowan Harwood, Jan Riley, Tracey Sach and Wayne Sunman

    Citation: Trials 2007 8:19

    Content type: Study protocol

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  10. There is increasing interest in developing peer-led and 'expert patient'-type interventions, particularly to meet the support and informational needs of those with long term conditions, leading to improved cli...

    Authors: Jeremy Dale, Isabela Caramlau, Andrea Docherty, Jackie Sturt and Hilary Hearnshaw

    Citation: Trials 2007 8:18

    Content type: Study protocol

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  11. Cerebral microembolism detected by transcranial Doppler (TCD) occurs systematically during cardiac catheterization, but its clinical relevance, remains unknown. Studies suggest that asymptomatic embolic cerebr...

    Authors: Michèle Hamon, Francesco Burzotta, Catherine Oppenheim, Rémy Morello, Fausto Viader and Martial Hamon

    Citation: Trials 2007 8:15

    Content type: Study protocol

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  12. Previous trials of the RTS, S malaria candidate vaccine have shown that this vaccine is safe, tolerated and immunogenic. The development plan for this vaccine aims at administering it in the first year of life...

    Authors: Eusebio V Macete, Jahit Sacarlal, John J Aponte, Amanda Leach, Margarita M Navia, Jessica Milman, Caterina Guinovart, Inacio Mandomando, Yolanda López-Púa, Marc Lievens, Alex Owusu-Ofori, Marie-Claude Dubois, Conor P Cahill, Marguerite Koutsoukos, Marla Sillman, Ricardo Thompson…

    Citation: Trials 2007 8:11

    Content type: Research

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  13. The n-of-1 trial offers a more methodologically sound approach to determining optimum treatment for an individual patient than "trials of therapy" routinely conducted in clinical practice. However, such method...

    Authors: Sara T Brookes, Lucy Biddle, Charlotte Paterson, Gillian Woolhead and Paul Dieppe

    Citation: Trials 2007 8:10

    Content type: Methodology

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  14. C.E.R.A. (Continuous Erythropoietin Receptor Activator) is an innovative agent with unique erythropoietin receptor activity and prolonged half-life. This study evaluated C.E.R.A. once weekly (QW) or once every...

    Authors: Vera Hirsh, John Glaspy, Paul Mainwaring, Christian Manegold, Rodryg Ramlau and Joseph E Eid

    Citation: Trials 2007 8:8

    Content type: Research

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  15. Self-care interventions are promoted as effective strategies for improving the quality of life and health outcomes for individuals with long-term health conditions. Outcome measures used in evaluations using R...

    Authors: Anne Rogers, Victoria Lee and Anne Kennedy

    Citation: Trials 2007 8:6

    Content type: Research

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  16. The use of handheld computers in medicine has increased in the last decade, they are now used in a variety of clinical settings. There is an underlying assumption that electronic data capture is more accurate ...

    Authors: Tania M Shelby-James, Amy P Abernethy, Andrew McAlindon and David C Currow

    Citation: Trials 2007 8:5

    Content type: Letter

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  17. Qualitative methods are increasingly used to study the process of clinical trials and patients understanding of the rationale for trials, randomisation and reasons for taking part or refusing. Patients' unders...

    Authors: Sue Ziebland, Katie Featherstone, Claire Snowdon, Karen Barker, Helen Frost and Jeremy Fairbank

    Citation: Trials 2007 8:4

    Content type: Research

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  18. This paper describes the results of a feasibility study for a randomised controlled trial (RCT).

    Authors: Kim S Thomas, Neil H Cox, Boki SP Savelyich, Debbie Shipley, Sarah Meredith, Andrew Nunn, Nick Reynolds and Hywel C Williams

    Citation: Trials 2007 8:3

    Content type: Research

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  19. Cardiovascular diseases are the major cause of death in the world. Current treatments have not been able to reverse this scenario, creating the need for the development of new therapies. Cell therapies have em...

    Authors: Bernardo R Tura, Helena F Martino, Luis H Gowdak, Ricardo Ribeiro dos Santos, Hans F Dohmann, José E Krieger, Gilson Feitosa, Fábio Vilas-Boas, Sérgio A Oliveira, Suzana A Silva, Augusto Z Bozza, Radovan Borojevic and Antonio C Campos de Carvalho

    Citation: Trials 2007 8:2

    Content type: Study protocol

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  20. In the United Kingdom (UK), there is an extensive market for the class 'A' drug heroin. Many heroin users spend time in prison. People addicted to heroin often require prescribed medication when attempting to ...

    Authors: Laura Sheard, Clive E Adams, Nat MJ Wright, Hany El-Sayeh, Richard Dalton and Charlotte NE Tompkins

    Citation: Trials 2007 8:1

    Content type: Study protocol

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  21. Many patients at high risk of cardiovascular disease do not achieve recommended low-density lipoprotein cholesterol (LDL-C) goals. This study compared the efficacy and safety of low doses of rosuvastatin (10 m...

    Authors: Michael B Clearfield, John Amerena, Jean-Pierre Bassand, Hugo R Hernández García, Sam S Miller, Froukje FM Sosef, Michael K Palmer and Brian S Bryzinski

    Citation: Trials 2006 7:35

    Content type: Research

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  22. Securing and managing finances for multicentre randomised controlled trials is a highly complex activity which is rarely considered in the research literature. This paper describes the process of financial neg...

    Authors: Claire Snowdon, Diana R Elbourne, Jo Garcia, Marion K Campbell, Vikki A Entwistle, David Francis, Adrian M Grant, Rosemary C Knight, Alison M McDonald and Ian Roberts

    Citation: Trials 2006 7:34

    Content type: Research

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  23. The Hypertension in the Very Elderly Trial (HYVET) is a placebo controlled double blind trial of treating hypertension with indapamide Slow Release (SR) ± perindopril in subjects over the age of 80 years. The ...

    Authors: Christopher J Bulpitt, Ruth Peters, Jan A Staessen, Lutgarde Thijs, Marie-Christine De Vernejoul, Astrid E Fletcher and Nigel S Beckett

    Citation: Trials 2006 7:33

    Content type: Study protocol

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  24. Findings from both epidemiological and basic research point to the possibility that NSAIDS impede the deterioration in schizophrenia.

    Authors: Wijnand Laan, Jean-Paul Selten, René S Kahn, Anne-Margriet Huisman, Cobi J Heijnen, Diederick E Grobbee and Huibert Burger

    Citation: Trials 2006 7:31

    Content type: Study protocol

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  25. Patients with a hemispheric infarct and massive space-occupying brain oedema have a poor prognosis. Despite maximal conservative treatment, the case fatality rate may be as high as 80%, and most survivors are ...

    Authors: Jeannette Hofmeijer, G Johan Amelink, Ale Algra, Jan van Gijn, Malcolm R Macleod, L Jaap Kappelle and H Bart van der Worp

    Citation: Trials 2006 7:29

    Content type: Study protocol

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  26. The raising prevalence of type-2 diabetes mellitus and obesity has been recognized as a major problem for public health, affecting both developed and developing countries. Impaired fasting plasma glucose has b...

    Authors: Patricio López-Jaramillo, Lina P Pradilla, Vicente Lahera, Federico A Silva Sieger, Christian F Rueda-Clausen and Gustavo A Márquez

    Citation: Trials 2006 7:28

    Content type: Study protocol

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  27. Annually, more than 90000 surgical procedures of the thyroid gland are performed in Germany. Strategies aimed at reducing the duration of the surgical procedure are relevant to patients and the health care sys...

    Authors: CM Seiler, BE Fröhlich, JA Veit, E Gazyakan, MN Wente, C Wollermann, A Deckert, S Witte, N Victor, MW Buchler and HP Knaebel

    Citation: Trials 2006 7:27

    Content type: Study protocol

    Published on:

  28. Common deterrents to insulin therapy for both physicians and patients are the complexity and burden of daily injections. In January 2006, the first inhaled human insulin (INH, Exubera® (insulinhuman [rDNA origin]...

    Authors: Nick Freemantle and Thomas R Strack

    Citation: Trials 2006 7:25

    Content type: Study protocol

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  29. In ageing men testosterone levels decline, while cognitive function, muscle and bone mass, sexual hair growth, libido and sexual activity decline and the risk of cardiovascular diseases increase. We set up a d...

    Authors: Hamid Reza Nakhai Pour, Marielle H Emmelot-Vonk, Marja Sukel-Helleman, Harald JJ Verhaar, Diederick E Grobbee and Yvonne T van der Schouw

    Citation: Trials 2006 7:24

    Content type: Study protocol

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  30. Thirty thousand knee replacements are performed annually in the UK. There is uncertainty as to the best surgical approach to the knee joint for knee arthroplasty. We planned a randomised controlled trial to co...

    Authors: Stephen Bridgman, Gayle Walley, Gilbert MacKenzie, Darren Clement, David Griffiths and Nicola Maffulli

    Citation: Trials 2006 7:23

    Content type: Study protocol

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  31. Chagas' disease is the major cause of disability secondary to tropical diseases in young adults from Latin America, and around 20 million people are currently infected by T. cruzi. Heart failure due to Chagas car...

    Authors: Franklin R Quiros, Carlos A Morillo, Juan P Casas, Luz A Cubillos and Federico A Silva

    Citation: Trials 2006 7:21

    Content type: Study protocol

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  32. The insertion of a Totally Implantable Access Port (TIAP) is a routinely employed technique in patients who need a safe and permanent venous access. The number of TIAP implantations is increasing constantly ma...

    Authors: P Knebel, B Fröhlich, H-P Knaebel, P Kienle, S Luntz, MW Buchler and CM Seiler

    Citation: Trials 2006 7:20

    Content type: Study protocol

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  33. Infection promotes coagulation via a large number of molecular and cellular mechanisms, and this procoagulant activity has boosted basic and clinical research using anticoagulant molecules as therapeutic tools...

    Authors: Fabián Jaimes, Gisela De La Rosa, Clara Arango, Fernando Fortich, Carlos Morales, Daniel Aguirre and Pablo Patiño

    Citation: Trials 2006 7:19

    Content type: Study protocol

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  34. Implantable Cardioverter Defibrillator (ICD) therapy has been proven to be beneficial and efficacious for the treatment of serious ventricular tachyarrhythmias in primary prevention patients. However, primary ...

    Authors: Bruce L Wilkoff, Richard Stern, Brian Williamson, Mark Wathen, Keith Holloman, Ann Fieberg and Mark Brown

    Citation: Trials 2006 7:18

    Content type: Study protocol

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  35. To determine the safety and logistic feasibility of a mass immunization strategy outside the local immunization program in the pediatric population of urban squatter settlements in Karachi, Pakistan.

    Authors: Mohammad Imran Khan, Rion Leon Ochiai, Hasan Bin Hamza, Shah Muhammad Sahito, Muhammad Atif Habib, Sajid Bashir Soofi, Naveed Sarwar Bhutto, Shahid Rasool, Mahesh K Puri, Mohammad Ali, Shafi Mohammad Wasan, Mohammad Jawed Khan, Remon Abu-Elyazeed, Bernard Ivanoff, Claudia M Galindo, Tikki Pang…

    Citation: Trials 2006 7:17

    Content type: Research

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  36. Cutaneous Leishmaniasis is a worldwide disease, endemic in 88 countries, that has shown an increasing incidence over the last two decades. So far, pentavalent antimony compounds have been considered the treatm...

    Authors: Sandra Y Silva, Ligia C Rueda, Marcos López, Iván D Vélez, Christian F Rueda-Clausen, Daniel J Smith, Gerardo Muñoz, Hernando Mosquera, Federico A Silva, Adriana Buitrago, Holger Díaz and Patricio López-Jaramillo

    Citation: Trials 2006 7:14

    Content type: Study protocol

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  37. Service users within the NHS are increasingly being asked to participate in clinical research. In Liverpool Women's NHS Foundation Trust, approximately 35% of women take part in research during their pregnancy...

    Authors: Gillian Vernon, Zarko Alfirevic and Andrew Weeks

    Citation: Trials 2006 7:13

    Content type: Commentary

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