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  1. Although considered the reference standard for generating valid scientific evidence of a treatment's benefits and harms, the number of Randomised Controlled Trials (RCT) comparing surgical techniques remains l...

    Authors: Nuh N Rahbari, Markus K Diener, Lars Fischer, Moritz N Wente, Peter Kienle, Markus W Büchler and Christoph M Seiler

    Citation: Trials 2008 9:3

    Content type: Methodology

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  2. In some randomized trials successful laparoscopic cholecystectomy for cholecystitis is associated with an earlier recovery and shorter hospital stay when compared with open cholecystectomy. Other studies did n...

    Authors: Fausto Catena, Luca Ansaloni, Salomone Di Saverio, Filippo Gazzotti, Stefano Gagliardi, Federico Coccolini, Luigi D'Alessandro, Giorgio Ercolani, Carlo Talarico, Uberto A Bassi, Leonardo Leone, Filippo Calzolari and Antonio D Pinna

    Citation: Trials 2008 9:1

    Content type: Study protocol

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  3. Recruiting to trials is complex and difficult. The Prevention of Pelvic Infection (POPI) trial aims to see if screening women for chlamydia and treating those found to be infected reduces the incidence of pelv...

    Authors: Helen Atherton, Debbie Banks, Ruth Harbit, Linzie Long, Fiona Chadd, Phillip Hay, Sally Kerry, Ian Simms and Pippa Oakeshott

    Citation: Trials 2007 8:41

    Content type: Methodology

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  4. In recent years there has been an increasing interest in MRI as a non-invasive diagnostic modality for the work-up of suspicious breast lesions. The additional value of Breast MRI lies mainly in its capacity t...

    Authors: Nicky HGM Peters, Inne HM Borel Rinkes, Willem PTM Mali, Maurice AAJ van den Bosch, Remmert K Storm, Peter W Plaisier, Erwin de Boer, Adriaan J van Overbeeke and Petra HM Peeters

    Citation: Trials 2007 8:40

    Content type: Study protocol

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  5. OMERACT is the acronym for an international, informally organized network initiated in 1992 aimed at improving outcome measurement in rheumatology. Chaired by an executive committee, it organizes consensus con...

    Authors: Peter Tugwell, Maarten Boers, Peter Brooks, Lee Simon, Vibeke Strand and Leanne Idzerda

    Citation: Trials 2007 8:38

    Content type: Commentary

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  6. Publicly funded clinical trials require a substantial commitment of time and money. To ensure that sufficient numbers of patients are recruited it is essential that they address important questions in a rigoro...

    Authors: David Francis, Ian Roberts, Diana R Elbourne, Haleema Shakur, Rosemary C Knight, Jo Garcia, Claire Snowdon, Vikki A Entwistle, Alison M McDonald, Adrian M Grant and Marion K Campbell

    Citation: Trials 2007 8:37

    Content type: Research

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  7. Anaemia is a common complication of chronic kidney disease and prevalence increases with declining renal function. Renal anaemia has significant implications for the well-being and quality of life of patients ...

    Authors: Iain C Macdougall

    Citation: Trials 2007 8:35

    Content type: Study protocol

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  8. The choice of antiepileptic drug for an individual should be based upon the highest quality evidence regarding potential benefits and harms of the available treatments. Systematic reviews and meta-analysis of ...

    Authors: Catrin Tudur Smith, Anthony G Marson, David W Chadwick and Paula R Williamson

    Citation: Trials 2007 8:34

    Content type: Research

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  9. The standard care in patients with a painful osteoporotic vertebral compression fracture (VCF) is conservative therapy. Percutaneous vertebroplasty (PV), a minimally invasive technique, is gaining popularity a...

    Authors: CAH Klazen, HJJ Verhaar, LEH Lampmann, JR Juttmann, MC Blonk, FH Jansen, AV Tielbeek, MC Schoemaker, E Buskens, Y van der Graaf, X Janssens, H Fransen, KJ van Everdingen, AF Muller, WPThM Mali and PNM Lohle

    Citation: Trials 2007 8:33

    Content type: Study protocol

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  10. The standard whole-colon tests used to investigate patients with symptoms of colorectal cancer are barium enema and colonoscopy. Colonoscopy is the reference test but is technically difficult, resource intensi...

    Authors: Steve Halligan, Richard J Lilford, Jane Wardle, Dion Morton, Pauline Rogers, Katherine Wooldrage, Rob Edwards, Reshma Kanani, Urvi Shah and Wendy Atkin

    Citation: Trials 2007 8:32

    Content type: Study protocol

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  11. Acute cholecystitis occurs frequently in the elderly and in patients with gall stones. Most cases of severe or recurrent cholecystitis eventually require surgery, usually laparoscopic cholecystectomy in the We...

    Authors: Kilian Weigand, Jörg Köninger, Jens Encke, Markus W Büchler, Wolfgang Stremmel and Carsten N Gutt

    Citation: Trials 2007 8:29

    Content type: Study protocol

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  12. Medication errors, adverse drug events and potential adverse drug events are common and serious in terms of the harms and costs that they impose on the health system and those who use it. Errors resulting in p...

    Authors: Merrick F Zwarenstein, Katie N Dainty, Sherman Quan, Alex Kiss and Neill KJ Adhikari

    Citation: Trials 2007 8:28

    Content type: Study protocol

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  13. Distraction osteogenesis is the standard treatment for the management of lower limb length discrepancy of more than 3 cm and bone loss secondary to congenital anomalies, trauma or infection. This technique con...

    Authors: Reggie C Hamdy, Kathleen Montpetit, Joanne Ruck-Gibis, Kelly Thorstad, Ellen Raney, Michael Aiona, Robert Platt, Allen Finley, William Mackenzie, James McCarthy and Unni Narayanan

    Citation: Trials 2007 8:27

    Content type: Study protocol

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  14. Diabetes Mellitus constitutes one of the most important public health problems due to its high prevalence and enormous social and economic consequences. Diabetic foot ulcers are one of the chronic complication...

    Authors: Sandra Y Silva, Ligia C Rueda, Gustavo A Márquez, Marcos López, Daniel J Smith, Carlos A Calderón, Juan C Castillo, Jaime Matute, Christian F Rueda-Clausen, Arturo Orduz, Federico A Silva, Piyaporn Kampeerapappun, Mahesh Bhide and Patricio López-Jaramillo

    Citation: Trials 2007 8:26

    Content type: Study protocol

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  15. Mortality rates in the Intensive Care Unit and subsequent hospital mortality rates in the UK remain high. Infections in Intensive Care are associated with a 2–3 times increased risk of death. It is thought tha...

    Authors: Peter JD Andrews, Alison Avenell, David W Noble, Marion K Campbell, Claire G Battison, Bernard L Croal, William G Simpson, John Norrie, Luke D Vale, Jonathon Cook, Robyn de Verteuil and Anne C Milne

    Citation: Trials 2007 8:25

    Content type: Study protocol

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  16. In orthodontic treatment, anchorage control is a fundamental aspect. Usually conventional mechanism for orthodontic anchorage control can be either extraoral or intraoral that is headgear or intermaxillary ela...

    Authors: Britta A Jung, Heinrich Wehrbein, Werner Hopfenmüller, Winfried Harzer, Tomasz Gedrange, Peter Diedrich and Martin Kunkel

    Citation: Trials 2007 8:24

    Content type: Study protocol

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  17. Despite a burgeoning interest in using interprofessional approaches to promote effective collaboration in health care, systematic reviews find scant evidence of benefit. This protocol describes the first clust...

    Authors: Merrick Zwarenstein, Scott Reeves, Ann Russell, Chris Kenaszchuk, Lesley Gotlib Conn, Karen-Lee Miller, Lorelei Lingard and Kevin E Thorpe

    Citation: Trials 2007 8:23

    Content type: Study protocol

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  18. Secondary hyperparathyroidism (sHPT) is common in patients with chronic renal failure. Despite the initiation of new therapeutic agents, several patients will require parathyroidectomy (PTX). Total PTX with au...

    Authors: Katja Schlosser, Johannes A Veit, Stefan Witte, Emilio Domínguez Fernández, Norbert Victor, Hans-Peter Knaebel, Christoph M Seiler and Matthias Rothmund

    Citation: Trials 2007 8:22

    Content type: Study protocol

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  19. Despite the high cardiovascular risk, evidence of efficacy of preventive strategies in individuals with diabetes is scant. In particular, recommendations on the use of aspirin in patients with diabetes mostly ...

    Authors: Giorgia De Berardis, Michele Sacco, Virgilio Evangelista, Alessandro Filippi, Carlo B Giorda, Gianni Tognoni, Umberto Valentini and Antonio Nicolucci

    Citation: Trials 2007 8:21

    Content type: Study protocol

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  20. Patients with end stage liver disease are characteristically malnourished which is associated with poor outcome. Formulas enriched with arginine, ω-3 fatty acids, and nucleotides, "immunonutrients", potentiall...

    Authors: Arash Nickkholgh, Heinz Schneider, Jens Encke, Markus W Büchler, Jan Schmidt and Peter Schemmer

    Citation: Trials 2007 8:20

    Content type: Study protocol

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  21. Dysphagia occurs in up to 50% of patients admitted to hospital with acute strokes with up to 27% remaining by seven days. Up to 8% continue to have swallowing problems six months after their stroke with 1.7% s...

    Authors: Jessica R Beavan, Simon Conroy, Jo Leonardi-Bee, Tim Bowling, Catherine Gaynor, John Gladman, Dawn Good, Peter Gorman, Rowan Harwood, Jan Riley, Tracey Sach and Wayne Sunman

    Citation: Trials 2007 8:19

    Content type: Study protocol

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  22. There is increasing interest in developing peer-led and 'expert patient'-type interventions, particularly to meet the support and informational needs of those with long term conditions, leading to improved cli...

    Authors: Jeremy Dale, Isabela Caramlau, Andrea Docherty, Jackie Sturt and Hilary Hearnshaw

    Citation: Trials 2007 8:18

    Content type: Study protocol

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  23. Cerebral microembolism detected by transcranial Doppler (TCD) occurs systematically during cardiac catheterization, but its clinical relevance, remains unknown. Studies suggest that asymptomatic embolic cerebr...

    Authors: Michèle Hamon, Francesco Burzotta, Catherine Oppenheim, Rémy Morello, Fausto Viader and Martial Hamon

    Citation: Trials 2007 8:15

    Content type: Study protocol

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  24. Previous trials of the RTS, S malaria candidate vaccine have shown that this vaccine is safe, tolerated and immunogenic. The development plan for this vaccine aims at administering it in the first year of life...

    Authors: Eusebio V Macete, Jahit Sacarlal, John J Aponte, Amanda Leach, Margarita M Navia, Jessica Milman, Caterina Guinovart, Inacio Mandomando, Yolanda López-Púa, Marc Lievens, Alex Owusu-Ofori, Marie-Claude Dubois, Conor P Cahill, Marguerite Koutsoukos, Marla Sillman, Ricardo Thompson…

    Citation: Trials 2007 8:11

    Content type: Research

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  25. The n-of-1 trial offers a more methodologically sound approach to determining optimum treatment for an individual patient than "trials of therapy" routinely conducted in clinical practice. However, such method...

    Authors: Sara T Brookes, Lucy Biddle, Charlotte Paterson, Gillian Woolhead and Paul Dieppe

    Citation: Trials 2007 8:10

    Content type: Methodology

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  26. C.E.R.A. (Continuous Erythropoietin Receptor Activator) is an innovative agent with unique erythropoietin receptor activity and prolonged half-life. This study evaluated C.E.R.A. once weekly (QW) or once every...

    Authors: Vera Hirsh, John Glaspy, Paul Mainwaring, Christian Manegold, Rodryg Ramlau and Joseph E Eid

    Citation: Trials 2007 8:8

    Content type: Research

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  27. Self-care interventions are promoted as effective strategies for improving the quality of life and health outcomes for individuals with long-term health conditions. Outcome measures used in evaluations using R...

    Authors: Anne Rogers, Victoria Lee and Anne Kennedy

    Citation: Trials 2007 8:6

    Content type: Research

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  28. The use of handheld computers in medicine has increased in the last decade, they are now used in a variety of clinical settings. There is an underlying assumption that electronic data capture is more accurate ...

    Authors: Tania M Shelby-James, Amy P Abernethy, Andrew McAlindon and David C Currow

    Citation: Trials 2007 8:5

    Content type: Letter

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  29. Qualitative methods are increasingly used to study the process of clinical trials and patients understanding of the rationale for trials, randomisation and reasons for taking part or refusing. Patients' unders...

    Authors: Sue Ziebland, Katie Featherstone, Claire Snowdon, Karen Barker, Helen Frost and Jeremy Fairbank

    Citation: Trials 2007 8:4

    Content type: Research

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  30. This paper describes the results of a feasibility study for a randomised controlled trial (RCT).

    Authors: Kim S Thomas, Neil H Cox, Boki SP Savelyich, Debbie Shipley, Sarah Meredith, Andrew Nunn, Nick Reynolds and Hywel C Williams

    Citation: Trials 2007 8:3

    Content type: Research

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  31. Cardiovascular diseases are the major cause of death in the world. Current treatments have not been able to reverse this scenario, creating the need for the development of new therapies. Cell therapies have em...

    Authors: Bernardo R Tura, Helena F Martino, Luis H Gowdak, Ricardo Ribeiro dos Santos, Hans F Dohmann, José E Krieger, Gilson Feitosa, Fábio Vilas-Boas, Sérgio A Oliveira, Suzana A Silva, Augusto Z Bozza, Radovan Borojevic and Antonio C Campos de Carvalho

    Citation: Trials 2007 8:2

    Content type: Study protocol

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  32. In the United Kingdom (UK), there is an extensive market for the class 'A' drug heroin. Many heroin users spend time in prison. People addicted to heroin often require prescribed medication when attempting to ...

    Authors: Laura Sheard, Clive E Adams, Nat MJ Wright, Hany El-Sayeh, Richard Dalton and Charlotte NE Tompkins

    Citation: Trials 2007 8:1

    Content type: Study protocol

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  33. Many patients at high risk of cardiovascular disease do not achieve recommended low-density lipoprotein cholesterol (LDL-C) goals. This study compared the efficacy and safety of low doses of rosuvastatin (10 m...

    Authors: Michael B Clearfield, John Amerena, Jean-Pierre Bassand, Hugo R Hernández García, Sam S Miller, Froukje FM Sosef, Michael K Palmer and Brian S Bryzinski

    Citation: Trials 2006 7:35

    Content type: Research

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  34. Securing and managing finances for multicentre randomised controlled trials is a highly complex activity which is rarely considered in the research literature. This paper describes the process of financial neg...

    Authors: Claire Snowdon, Diana R Elbourne, Jo Garcia, Marion K Campbell, Vikki A Entwistle, David Francis, Adrian M Grant, Rosemary C Knight, Alison M McDonald and Ian Roberts

    Citation: Trials 2006 7:34

    Content type: Research

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  35. The Hypertension in the Very Elderly Trial (HYVET) is a placebo controlled double blind trial of treating hypertension with indapamide Slow Release (SR) ± perindopril in subjects over the age of 80 years. The ...

    Authors: Christopher J Bulpitt, Ruth Peters, Jan A Staessen, Lutgarde Thijs, Marie-Christine De Vernejoul, Astrid E Fletcher and Nigel S Beckett

    Citation: Trials 2006 7:33

    Content type: Study protocol

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  36. Findings from both epidemiological and basic research point to the possibility that NSAIDS impede the deterioration in schizophrenia.

    Authors: Wijnand Laan, Jean-Paul Selten, René S Kahn, Anne-Margriet Huisman, Cobi J Heijnen, Diederick E Grobbee and Huibert Burger

    Citation: Trials 2006 7:31

    Content type: Study protocol

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