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  1. The purpose of this study is to compare the efficacy of prophylactic antibiotic for prevention of meningitis in acute traumatic pneumocephalus patients.

    Authors: Behzad Eftekhar, Mohammad Ghodsi, Azar Hadadi, Mousa Taghipoor, Samira Zabihyan Sigarchi, Vafa Rahimi-Movaghar, Ehsan Sherafat Kazemzadeh, Babak Esmaeeli, Farideh Nejat, Alireza Yalda and Ebrahim Ketabchi

    Citation: Trials 2006 7:2

    Content type: Study protocol

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  2. Stent length serves as a predictor of restenosis in use of bare metal stents (BMS). This has been demonstrated in a feasibility study that used a single short BMS implant (<9 mm) in a high proportion of lesion...

    Authors: Ulrich Dietz, Cheryl Dauer and Heinz Lambertz

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:18

    Content type: Research

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  3. Cobalt chromium coronary stents are increasingly being used in percutaneous coronary interventions. There are, however, no reliable data about the characteristics of unfolding and visibility of this stent alloy i...

    Authors: Jens Hagemeister, Frank M Baer, Robert HG Schwinger and Hans W Höpp

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:17

    Content type: Research

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  4. Pharmacogenetic testing to individualize ACE inhibitor therapy remains controversial. We conducted a systematic review to assess the effect modification of the insertion/deletion (I/D) polymorphism of the ACE ...

    Authors: Madlaina Scharplatz, Milo A Puhan, Johann Steurer, Annalisa Perna and Lucas M Bachmann

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:16

    Content type: Research

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  5. Saphenous vein graft disease remains a major limitation of coronary artery bypass graft surgery. The process of saphenous vein intimal hyperplasia begins just days after surgical revascularization, setting the...

    Authors: Alexander Kulik, Michel Le May, George A Wells, Thierry G Mesana and Marc Ruel

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:15

    Content type: Study protocol

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  6. The aim of this prospective study of patients undergoing repair of non-ruptured abdominal aortic aneurysm between 1999 and 2003 was to evaluate and compare risk factors for mortality after surgery, to determin...

    Authors: Sigitas Urbonavicius, Henrik Vorum, Grazina Urbonaviciene, Mindaugas Trumpickas, Dainius Pavalkis and Bent Honoré

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:14

    Content type: Review

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  7. In high-risk coronary artery bypass patients; off-pump versus on-pump surgical strategies still remain a matter of debate, regarding which method results in a lower incidence of perioperative mortality and mor...

    Authors: Alper Sami Kunt, Osman Tansel Darcın and Mehmet Halit Andac

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:13

    Content type: Research

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  8. Cardiac biomarkers are routinely obtained in the setting of suspected myocardial ischemia and infarction. Evidence suggests these markers may correlate with functional and clinical outcomes, but the strength o...

    Authors: Aslan T Turer, Kenneth W Mahaffey, Dianne Gallup, W Douglas Weaver, Robert H Christenson, Nathan R Every and E Magnus Ohman

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:12

    Content type: Research

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  9. The aim of the SPHERE study is to design, implement and evaluate tailored practice and personal care plans to improve the process of care and objective clinical outcomes for patients with established coronary ...

    Authors: Andrew W Murphy, Margaret E Cupples, Susan M Smith, Molly Byrne, Claire Leathem and Mary C Byrne

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:11

    Content type: Research

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  10. Female cardiac transplant recipients' aerobic capacity is 60% lower than sex and age-predicted values. The effect of exercise training on restoring the impaired aerobic endurance and muscle strength in female ...

    Authors: Mark Haykowsky, Kenneth Riess, Linda Figgures, Daniel Kim, Darren Warburton, Lee Jones and Wayne Tymchak

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:10

    Content type: Research

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  11. Patients with end-stage renal disease (ESRD) are at high risk of cardiovascular events. Multiple risk factors for atherosclerosis are present in ESRD and may contribute to the increased risk of cardiovascular ...

    Authors: Bengt Fellström, Faiez Zannad, Roland Schmieder, Hallvard Holdaas, Alan Jardine, Helen Rose and Wim Wilpshaar

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:9

    Content type: Research

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  12. The high incidence of cardiovascular disease in patients with end stage renal disease (ESRD) is related to the accumulation of uremic toxins in the middle and large-middle molecular weight range. As online hem...

    Authors: E Lars Penne, Peter J Blankestijn, Michiel L Bots, Marinus A van den Dorpel, Muriel P Grooteman, Menso J Nubé, Ingeborg van der Tweel and Piet M ter Wee

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:8

    Content type: Research

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  13. Spinal cord electrical stimulation (SCS) has shown to be a treatment option for patients suffering from angina pectoris CCS III-IV although being on optimal medication and not suitable for conventional treatme...

    Authors: Holger Diedrichs, Carsten Zobel, Peter Theissen, Michael Weber, Athanassios Koulousakis, Harald Schicha and Robert HG Schwinger

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:7

    Content type: Research

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  14. Despite widespread availability of a large body of evidence in the area of hypertension, the translation of that evidence into viable recommendations aimed at improving the quality of health care is very diffi...

    Authors: Cornel Pater

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:6

    Content type: Review

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  15. Activation of inflammatory pathways plays an important contributory role in coronary plaque instability and subsequent rupture, which can lead to the development of acute coronary syndrome (ACS). Elevated leve...

    Authors: Petr Ostadal, David Alan, Petr Hajek, Jiri Vejvoda, Martin Mates, Peter Blasko, Josef Veselka, Milan Kvapil, Jiri Kettner, Martin Wiendl, Ondrej Aschermann, Josef Slaby, Eduard Nemecek, Frantisek Holm, Marek Rac, Milan Macek…

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:4

    Content type: Research

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  16. Surrogate measures for cardiovascular disease events have the potential to increase greatly the efficiency of clinical trials. A leading candidate for such a surrogate is the progression of intima-media thickn...

    Authors: Mark A Espeland, Daniel H O'Leary, James G Terry, Timothy Morgan, Greg Evans and Harald Mudra

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:3

    Content type: Review

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  17. Although the association between mitral stenosis (MS) and increased coagulation activity is well recognized, it is unclear whether enhanced coagulation remains localized in the left atrium or whether this repr...

    Authors: Istemihan Tengiz, Ertugrul Ercan, Fahri Sahin, Emin Alioglu, Can Duman, Guray Saydam and Filiz Buyukkececi

    Citation: Current Controlled Trials in Cardiovascular Medicine 2005 6:2

    Content type: Research

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  18. The delivery of implantable cardioverter defibrillator (ICD) therapy is sophisticated and requires the programming of over 100 settings. Physicians tailor these settings with the intention of optimizing ICD th...

    Authors: John M Morgan, Laurence D Sterns, Jodi L Hanson, Kevin T Ousdigian, Mary F Otterness and Bruce L Wilkoff

    Citation: Current Controlled Trials in Cardiovascular Medicine 2004 5:12

    Content type: Review

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  19. Although percutaneous coronary intervention (PCI) is becoming the standard therapy in ST-segment elevation myocardial infarction (STEMI), to date most patients, even in developed countries, are reperfused with...

    Authors: Ramon B van Loon, Gerrit Veen, Otto Kamp, Jean GF Bronzwaer, Cees A Visser and Frans C Visser

    Citation: Current Controlled Trials in Cardiovascular Medicine 2004 5:11

    Content type: Research

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  20. Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of arterial aneurysms through increased proteolysis of extracellular matrix proteins. Increased proteolysis due to elevated matrix degr...

    Authors: Istemihan Tengiz, Ertugrul Ercan, Emil Aliyev, Cevad Sekuri, Can Duman and Imre Altuglu

    Citation: Current Controlled Trials in Cardiovascular Medicine 2004 5:10

    Content type: Research

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  21. Hypertension and diabetes mellitus are closely interrelated and coexist in as many as two-thirds of patients with type 2 diabetes. The consequent risk of such an association is an accelerated development of at...

    Authors: Cornel Pater, Deepak Bhatnagar, Jean-Pascal Berrou, Joachim Luszick and Katrin Beckmann

    Citation: Current Controlled Trials in Cardiovascular Medicine 2004 5:9

    Content type: Research

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  22. A large number of randomized clinical trials with important health outcomes are completed each year. Those with favorable findings are typically reported and published rapidly, while the publication of those w...

    Authors: Curt D Furberg, Mark A Hall and Mary Ann Sevick

    Citation: Current Controlled Trials in Cardiovascular Medicine 2004 5:6

    Content type: Commentary

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  23. Noncompliance with study medications is an important issue in the design of endpoint clinical trials. Including noncompliant patient data in an intention-to-treat analysis could seriously decrease study power....

    Authors: Steven M Snapinn, Qi Jiang and Boris Iglewicz

    Citation: Current Controlled Trials in Cardiovascular Medicine 2004 5:5

    Content type: Review

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  24. The existence of effective therapies for most cardiovascular disease states, coupled with increased requirements that potential benefits of new drugs be evaluated on clinical rather than surrogate endpoints, m...

    Authors: Cornel Pater

    Citation: Current Controlled Trials in Cardiovascular Medicine 2004 5:4

    Content type: Review

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  25. Ximelagatran is a novel oral direct thrombin inhibitor. It has favorable pharmacodynamic properties, with a broad therapeutic range without the need for anticoagulation monitoring. We aimed to discover whether...

    Authors: Christopher J Boos and Ranjit S More

    Citation: Current Controlled Trials in Cardiovascular Medicine 2004 5:3

    Content type: Review

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  26. Trials in the 1990s demonstrated that medical therapy is as effective as invasive therapies for treating single-vessel coronary disease. Yet more recent studies enrolling patients with this condition have focu...

    Authors: Samer Jabbour, Shmuel Ravid and Bernard Lown

    Citation: Current Controlled Trials in Cardiovascular Medicine 2004 5:2

    Content type: Review

    Published on:

  27. In order to avoid the complications associated with thromboembolic disease, patients with this condition typically are placed on long-term anticoagulant therapy. This report compares bleeding complications in ...

    Authors: Ufuk Yetkin, Özalp Karabay and Hakan Önol

    Citation: Current Controlled Trials in Cardiovascular Medicine 2004 5:1

    Content type: Research

    Published on:

  28. A large body of data derived from animal, epidemiological and clinical studies indicate that n-3 polyunsaturated fatty acids have a favourable effect on the prognosis of patients with cardiovascular disease in...

    Authors: Cornel Pater, Daniele Compagnone, Joachim Luszick and Cees-Nico Verboom

    Citation: Current Controlled Trials in Cardiovascular Medicine 2003 4:2

    Content type: Research

    Published on:

  29. Currently, there are a lack of investigations that have examined the effect of participating in a comprehensive cardiac rehabilitation program on quality of life and physiological measures in women of differen...

    Authors: Michael D Kennedy, Mark Haykowsky, Bill Daub, Karen van Lohuizen, Grant Knapik and Bill Black

    Citation: Current Controlled Trials in Cardiovascular Medicine 2003 4:1

    Content type: Research

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  30. The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is a randomized, double-blind, active-controlled trial designed to compare the rate of coronary heart disease events in ...

    Authors: Linda B Piller, Barry R Davis, Jeffrey A Cutler, William C Cushman, Jackson T Wright Jr, Jeff D Williamson, Frans HH Leenen, Paula T Einhorn, Otelio S Randall, John S Golden and L Julian Haywood

    Citation: Current Controlled Trials in Cardiovascular Medicine 2002 3:10

    Content type: Research

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  31. Cardiac rehabilitation programs (CRP) represent comprehensive interventions that are typically limited to four months. Following completion of CRP, it appears that risk factors and lifestyle behaviours may det...

    Authors: Scott A Lear, Andrew Ignaszewski, Wolfgang Linden, Anka Brozic, Marla Kiess, John J Spinelli, P Haydn Pritchard and Jiri J Frohlich

    Citation: Current Controlled Trials in Cardiovascular Medicine 2002 3:9

    Content type: Research

    Published on:

  32. PROSPER was designed to investigate the benefits of treatment with pravastatin in elderly patients for whom a typical doctor might consider the prescription of statin therapy to be a realistic option.

    Authors: Ian Ford, Gerard Jan Blauw, Michael B Murphy, James Shepherd, Stuart M Cobbe, Edward LEM Bollen, Brendan M Buckley, J Wouter Jukema, Michael Hyland, Allan Gaw, A Margot Lagaay, Ivan J Perry, Peter Macfarlane, John Norrie, A Edo Meinders, Brian J Sweeney…

    Citation: Current Controlled Trials in Cardiovascular Medicine 2002 3:8

    Content type: Research

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  33. The "integrated safety report" of the drug registration files submitted to health authorities usually summarizes the rates of adverse events observed for a new drug, placebo or active control drugs by pooling ...

    Authors: Michel Lièvre, Michel Cucherat and Alain Leizorovicz

    Citation: Current Controlled Trials in Cardiovascular Medicine 2002 3:6

    Content type: Commentary

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  34. Antioxidant supplementation with vitamin E had no effect in the prevention of cardiovascular diseases (CVD) in three recent large, randomized clinical trials. In order to reassess critically the role of vitami...

    Authors: Chiara Chiabrando, Fausto Avanzini, Claudia Rivalta, Fabio Colombo, Roberto Fanelli, Gaetana Palumbo and Maria Carla Roncaglioni

    Citation: Current Controlled Trials in Cardiovascular Medicine 2002 3:5

    Content type: Research

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  35. The Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study was the first trial to assess whether statins might be of clinical benefit in those with recently unstable coronary disease. M...

    Authors: Herbert D Aronow

    Citation: Current Controlled Trials in Cardiovascular Medicine 2002 3:3

    Content type: Commentary

    Published on:

  36. Although diabetes mellitus is predominantly a metabolic disorder, recent data suggest that it is as much a vascular disorder. Cardiovascular complications are the leading cause of death and disability in patie...

    Authors: Prakash C Deedwania

    Citation: Current Controlled Trials in Cardiovascular Medicine 2002 3:2

    Content type: Review

    Published on:

  37. Overweight older adults are often counseled to lose weight, even though there is little evidence of excess mortality in that age group. Overweight and underweight may be more associated with health status than...

    Authors: Paula Diehr, Anne B Newman, Sharon A Jackson, Lewis Kuller and Neil Powe

    Citation: Current Controlled Trials in Cardiovascular Medicine 2002 3:1

    Content type: Research

    Published on:

  38. The treatment of patients with coronary artery disease continues to evolve; all three strategies – medical therapy, surgical revascularization, and percutaneous coronary intervention – have changed. Medical th...

    Authors: David R Holmes Jr

    Citation: Trials 2001 2:263

    Content type: Commentary

    Published on:

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