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  1. Psychotic disorders are a serious mental health problem. Intervention before the onset of psychosis might result in delaying the onset, reducing the impact or even preventing the first episode of psychosis. Th...

    Authors: Judith Rietdijk, Sara Dragt, Rianne Klaassen, Helga Ising, Dorien Nieman, Lex Wunderink, Philippe Delespaul, Pim Cuijpers, Don Linszen and Mark van der Gaag

    Citation: Trials 2010 11:30

    Content type: Study protocol

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  2. Pain is one of the most frequent and distressing symptoms in cancer patients. For the majority of the patients, sufficient pain relief can be obtained if adequate treatment is provided. However, pain remains o...

    Authors: Patrick Jahn, Maria Kitzmantel, Petra Renz, Ene Kukk, Oliver Kuss, Anette Thoke-Colberg, Ingrid Horn and Margarete Landenberger

    Citation: Trials 2010 11:29

    Content type: Study protocol

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  3. Recent cohort studies of randomised controlled trials have provided evidence of within-study selective reporting bias; where statistically significant outcomes are more likely to be more completely reported co...

    Authors: Joanne E McKenzie, G Peter Herbison, Paul Roth and Charlotte Paul

    Citation: Trials 2010 11:28

    Content type: Commentary

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  4. Pre-diabetes is a growing health concern where a large percentage of these patients develop full type 2 diabetes. Effective interventions on pre-diabetes can prevent or delay the occurrence or development of d...

    Authors: Hongbo Cao, Ming Ren, Liping Guo, Hongcai Shang, Junhua Zhang, Yuzhen Song, Hui Wang, Baohe Wang, Xiantao Li, Jing Hu, Xuemei Wang, Dehui Wang, Jianzong Chen, Shuanglei Li and Liming Chen

    Citation: Trials 2010 11:27

    Content type: Study protocol

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  5. The incidence of venous ulceration is rising with the increasing age of the general population. Venous ulceration represents the most prevalent form of difficult to heal wounds and these problematic wounds req...

    Authors: Carolina D Weller, Sue Evans, Christopher M Reid, Rory Wolfe and John McNeil

    Citation: Trials 2010 11:26

    Content type: Study protocol

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  6. Suicide, attempted suicide and suicidal thoughts are major public health problems worldwide. Effective face-to-face treatments are Cognitive Behavioural Therapy (CBT), Dialectical Behavioural Therapy (DBT) and...

    Authors: Bregje A J van Spijker, Annemieke van Straten and Ad J F M Kerkhof

    Citation: Trials 2010 11:25

    Content type: Study protocol

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  7. Low back pain (LBP) is a prevalent and costly condition in the United States. Evidence suggests there is no one treatment which is best for all patients, but instead several viable treatment options. Additiona...

    Authors: Kristine K Westrom, Michele J Maiers, Roni L Evans and Gert Bronfort

    Citation: Trials 2010 11:24

    Content type: Study protocol

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  8. Authors: Anthony J Avery, Sarah Rodgers, Judith A Cantrill, Sarah Armstrong, Rachel Elliott, Rachel Howard, Denise Kendrick, Caroline J Morris, Scott A Murray, Robin J Prescott, Kathrin Cresswell and Aziz Sheikh

    Citation: Trials 2010 11:23

    Content type: Erratum

    Published on:

    The original article was published in Trials 2009 10:28

  9. In Major Depressive Disorder (MDD), the traditional belief of a delayed onset of antidepressants' effects has lead to the concept of current guidelines that treatment durations should be between 3-8 weeks befo...

    Authors: André Tadić, Stanislav Gorbulev, Norbert Dahmen, Christoph Hiemke, Dieter F Braus, Joachim Röschke, Dietrich van Calker, Daniel Wachtlin, Kai Kronfeld, Thorsten Gorbauch, Monika Seibert-Grafe and Klaus Lieb

    Citation: Trials 2010 11:21

    Content type: Study protocol

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  10. The purpose of the study was to evaluate systematic reviews of research into two public health priorities, tobacco consumption and HIV infection, in terms of the reporting of data related to the applicability ...

    Authors: Nizar Ahmad, Isabelle Boutron, Agnès Dechartres, Pierre Durieux and Philippe Ravaud

    Citation: Trials 2010 11:20

    Content type: Research

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  11. Depression frequently occurs in the elderly and in patients suffering from dementia. Its cause is largely unknown, but several studies point to a possible contribution of circadian rhythm disturbances. Post-mo...

    Authors: Els IS Most, Philip Scheltens and Eus JW Van Someren

    Citation: Trials 2010 11:19

    Content type: Study protocol

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  12. Borderline Personality Disorder (BPD) is a common mental disorder associated with raised mortality, morbidity and substantial economic costs. Although complex psychological interventions have been shown to be ...

    Authors: Paul Moran, Rohan Borschmann, Clare Flach, Barbara Barrett, Sarah Byford, Joanna Hogg, Morven Leese, Kim Sutherby, Claire Henderson, Diana Rose, Mike Slade, George Szmukler and Graham Thornicroft

    Citation: Trials 2010 11:18

    Content type: Study protocol

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  13. Enrolment of patients into a randomised controlled trial (RCT) in violation of key inclusion or exclusion criteria, may lead to excess avoidable harm. The purpose of this paper was to systematically identify a...

    Authors: Fiona Simpson, Elizabeth A Sweetman and Gordon S Doig

    Citation: Trials 2010 11:17

    Content type: Research

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  14. Earlier diagnosis followed by multi-factorial cardiovascular risk intervention may improve outcomes in Type 2 Diabetes Mellitus (T2DM). Latent phase identification through screening requires structured, approp...

    Authors: DR Webb, K Khunti, B Srinivasan, LJ Gray, N Taub, S Campbell, J Barnett, J Henson, S Hiles, A Farooqi, SJ Griffin, NJ Wareham and MJ Davies

    Citation: Trials 2010 11:16

    Content type: Study protocol

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  15. Various treatment options for the prosthetic treatment of jaws where all molars are lost are under discussion. Besides the placement of implants, two main treatment types can be distinguished: replacement of t...

    Authors: Ralph G Luthardt, Birgit Marré, Achim Heinecke, Joachim Gerss, Hans Aggstaller, Eckhard Busche, Paul Dressler, Ingrid Gitt, Wolfgang Hannak, Sinsa Hartmann, Guido Heydecke, Florentine Jahn, Matthias Kern, Torsten Mundt, Peter Pospiech, Helmut Stark…

    Citation: Trials 2010 11:15

    Content type: Study protocol

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  16. Previous research has shown the oxidizing properties and microbiological efficacies of chlorine dioxide (ClO2). Its clinical efficacies on oral malodor have been evaluated and reported only in short duration tria...

    Authors: Kayoko Shinada, Masayuki Ueno, Chisato Konishi, Sachiko Takehara, Sayaka Yokoyama, Takashi Zaitsu, Mari Ohnuki, Fredrick Allan Clive Wright and Yoko Kawaguchi

    Citation: Trials 2010 11:14

    Content type: Research

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  17. The National Dementia Strategy seeks to enhance general practitioners' diagnostic and management skills in dementia. Early diagnosis in dementia within primary care is important as this allows those with demen...

    Authors: Steve Iliffe, Jane Wilcock, Mark Griffin, Priya Jain, Ingela Thuné-Boyle, Tamar Koch and Frances Lefford

    Citation: Trials 2010 11:13

    Content type: Study protocol

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  18. Verrucae are a common, infectious and sometimes painful problem. The optimal treatment for verrucae is unclear due to a lack of high quality randomised controlled trials. The primary objective of this study is...

    Authors: E Sarah Cockayne

    Citation: Trials 2010 11:12

    Content type: Study protocol

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  19. There are controversies about the most effective treatment to eradicate first growth of Pseudomonas aeruginosa (P aeruginosa) from the lower airways of patients with cystic fibrosis (CF). UK guidelines recommend ...

    Authors: Helen R Hickey, Ashley P Jones, Warren Lenney, Paula R Williamson and Rosalind L Smyth

    Citation: Trials 2010 11:11

    Content type: Research

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  20. Performance of primary school students in India lags far below government expectations, and major disparity exists between rural and urban areas. The Naandi Foundation has designed and implemented a programme ...

    Authors: Alex Eble, Vera Mann, Preetha Bhakta, Rashmi Lakshminarayana, Chris Frost, Diana Elbourne and Peter Boone

    Citation: Trials 2010 11:10

    Content type: Study protocol

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  21. In recognition of the benefits of transparent reporting, many peer-reviewed journals require that their authors be prepared to share their raw, unprocessed data with other scientists and/or state the availabil...

    Authors: Iain Hrynaszkiewicz, Melissa L Norton, Andrew J Vickers and Douglas G Altman

    Citation: Trials 2010 11:9

    Content type: Editorial

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  22. Depression is a leading cause of disability worldwide and depressive symptoms are common in later life. Observational evidence suggests that depression is more prevalent among people with high plasma homocyste...

    Authors: Andrew H Ford, Leon Flicker, Kieran McCaul, Frank van Bockxmeer, Sarah Hegarty, Varsha Hirani, Stephen Fenner and Osvaldo P Almeida

    Citation: Trials 2010 11:8

    Content type: Study protocol

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  23. New Zealand has relatively high rates of morbidity and mortality from infectious disease compared with other OECD countries, with infectious disease being more prevalent in children compared with others in the...

    Authors: Joanne E McKenzie, Patricia Priest, Rick Audas, Marion R Poore, Cheryl R Brunton and Lesley M Reeves

    Citation: Trials 2010 11:7

    Content type: Study protocol

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  24. Regular physical activity reduces the risk of mortality from all causes, with a powerful beneficial effect on risk of falls and hip fractures. However, physical activity levels are low in the older population ...

    Authors: Steve Iliffe, Denise Kendrick, Richard Morris, Dawn Skelton, Heather Gage, Susie Dinan, Zoe Stevens, Mirilee Pearl and Tahir Masud

    Citation: Trials 2010 11:6

    Content type: Study protocol

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  25. Acute coronary syndromes, including myocardial infarction and unstable angina, are important causes of premature mortality, morbidity and hospital admissions. Acute coronary syndromes consume large amounts of ...

    Authors: Marcus D Flather, Jean Booth, Daphne Babalis, Hector Bueno, Philippe G Steg, Grzegorz Opolski, Filippo Ottani, Jacques Machecourt, Alfredo Bardaji, Mats Bojestig, Anthony R Brady and Bertil Lindahl

    Citation: Trials 2010 11:5

    Content type: Study protocol

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  26. The primary aim of this study was to compare the efficacy of three physical activity (PA) behavioural intervention strategies in a sample of adults with type 2 diabetes.

    Authors: Ronald C Plotnikoff, Kerry S Courneya, Ronald J Sigal, Jeffrey A Johnson, Nicholas Birkett, David Lau, Kim Raine, Steven T Johnson and Nandini Karunamuni

    Citation: Trials 2010 11:4

    Content type: Study protocol

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  27. Marfan syndrome (MFS) is one of the most common systemic disorders of connective tissue with the incidence of approximately 2-3 per 10 000 individuals. Aortic disease, leading to progressive aneurysmal dilatat...

    Authors: Teodora Radonic, Piet de Witte, Marieke JH Baars, Aeilko H Zwinderman, Barbara JM Mulder and Maarten Groenink

    Citation: Trials 2010 11:3

    Content type: Study protocol

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  28. Paclitaxel-eluting stents decrease angiographic and clinical restenosis following percutaneous coronary intervention compared to bare metal stents. TAXUS Element is a third-generation paclitaxel-eluting stent ...

    Authors: Dominic J Allocco, Louis A Cannon, Amy Britt, John E Heil, Andrey Nersesov, Scott Wehrenberg, Keith D Dawkins and Dean J Kereiakes

    Citation: Trials 2010 11:1

    Content type: Study protocol

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  29. Experts in Traditional Chinese Medicine (TCM) have studied the TCM subject of the pathogenesis of heart failure (HF) for several decades. As a result, the general idea is ben deficiency and biao excess. However, ...

    Authors: Jingyuan Mao, Yazhu Hou, Hongcai Shang, Henghe Wang, Xianliang Wang, Yingqiang Zhao, Tianfu Niu, Jinrong Cui, Guangping Li, Qian Lin, Le Shi, Xiuli Jia, Ruihong Fan, Baohe Wang, Hongwu Wang and Jishou Ruan

    Citation: Trials 2009 10:122

    Content type: Study protocol

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  30. The standard of care for metastatic gastric cancer (MGC) is systemic chemotherapy which leads to a median survival of 6-15 months. Survival beyond 3 years is rare. For selected groups of patients with limited ...

    Authors: Sid P Kerkar, Clinton D Kemp, Austin Duffy, Udai S Kammula, David S Schrump, King F Kwong, Martha Quezado, Barry R Goldspiel, Aradhana Venkatesan, Ann Berger, Melissa Walker, Mary Ann Toomey, Seth M Steinberg, Guiseppe Giaccone, Steven A Rosenberg and Itzhak Avital

    Citation: Trials 2009 10:121

    Content type: Study protocol

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  31. The implantable cardioverter defibrillator (ICD) is generally well accepted, but 25-33% of patients experience clinical levels of anxiety, depression, and impaired quality of life (QoL) following implantation....

    Authors: Susanne S Pedersen, Viola Spek, Dominic AMJ Theuns, Marco Alings, Pepijn van der Voort, Luc Jordaens, Pim Cuijpers, Johan Denollet and Krista C van den Broek

    Citation: Trials 2009 10:120

    Content type: Study protocol

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  32. Coronary artery disease is the leading cause of morbidity and mortality in patients with type 2 diabetes. Screening for asymptomatic coronary artery disease with treatment by means of revascularization seems t...

    Authors: Fabrizio Turrini, Roberto Messora, Paolo Giovanardi, Stefano Tondi, Paolo Magnavacchi, Rita Cavani, Giandomenico Tosoni, Carlo Cappelli, Elisa Pellegrini, Stefania Romano, Augusto Baldini, Romeo Giulietto Zennaro and Marco Bondi

    Citation: Trials 2009 10:119

    Content type: Study protocol

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  33. Modern radiotherapy plays an important role in therapy of advanced head and neck carcinomas. However, no clinical studies have been published addressing the effectiveness of postoperative radiotherapy in patie...

    Authors: Maximilian Moergel, Antje Jahn-Eimermacher, Frank Krummenauer, Torsten E Reichert, Wilfried Wagner, Thomas G Wendt, Jochen A Werner and Bilal Al-Nawas

    Citation: Trials 2009 10:118

    Content type: Study protocol

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  34. Research evidence from observational studies suggests that cognitive activity reduces the risk of cognitive impairment in later life as well as the rate of cognitive decline of people with dementia. The Promot...

    Authors: Mandy R Vidovich, Nicola T Lautenschlager, Leon Flicker, Linda Clare and Osvaldo P Almeida

    Citation: Trials 2009 10:114

    Content type: Study protocol

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  35. Bisphosphonates can reduce fracture risk in patients with osteoporosis, but many at-risk patients do not start or adhere to these medications. The aims of this study are to: (1) preliminarily evaluate the effe...

    Authors: Laurie J Pencille, Megan E Campbell, Holly K Van Houten, Nilay D Shah, Rebecca J Mullan, Brian A Swiglo, Maggie Breslin, Rebecca L Kesman, Sidna M Tulledge-Scheitel, Thomas M Jaeger, Ruth E Johnson, Gregory A Bartel, Robert A Wermers, L Joseph Melton III and Victor M Montori

    Citation: Trials 2009 10:113

    Content type: Study protocol

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  36. Dry eye is usually managed by conventional medical interventions such as artificial tears, anti-inflammatory drugs and surgical treatment. However, since dry eye is one of the most frequent ophthalmologic diso...

    Authors: Tae-Hun Kim, Jong-In Kim, Mi-Suk Shin, Myeong Soo Lee, Jun-Yong Choi, So-Yong Jung, Ae-Ran Kim, Jae-Uk Seol and Sun-Mi Choi

    Citation: Trials 2009 10:112

    Content type: Study protocol

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  37. A response to the letter regarding The BRAIN TRIAL: a randomized, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury, by Mr Vincent Simmon Presi...

    Authors: Ian Roberts and Haleema Shakur

    Citation: Trials 2009 10:111

    Content type: Letter

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  38. A response to and comment on The BRAIN TRIAL: a randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury, by Haleema Shakur, Ian Roberts, et ...

    Authors: Vincent F Simmon

    Citation: Trials 2009 10:110

    Content type: Letter

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  39. Cerebral oedema is associated with significant neurological damage in patients with traumatic brain injury. Bradykinin is an inflammatory mediator that may contribute to cerebral oedema by increasing the perme...

    Authors: Haleema Shakur, Peter Andrews, Toomas Asser, Laura Balica, Cristian Boeriu, Juan Diego Ciro Quintero, Yashbir Dewan, Patrick Druwé, Olivia Fletcher, Chris Frost, Bennie Hartzenberg, Jorge Mejia Mantilla, Francisco Murillo-Cabezas, Jan Pachl, Ramalingam R Ravi, Indrek Rätsep…

    Citation: Trials 2009 10:109

    Content type: Research

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  40. The UK has a strong tradition of innovative evaluative health care research. There are, however, considerable forces impeding collaboration between clinicians, academics, patients and their advocates and indus...

    Authors: Clive E Adams and Mauricio Silva de Lima

    Citation: Trials 2009 10:108

    Content type: Commentary

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  41. Bleeding is a frequent complication during surgery. The intraoperative administration of blood products, including packed red blood cells, platelets and fresh frozen plasma (FFP), is often live saving. Complic...

    Authors: Natalie Urwyler, Sven Trelle, Lorenz Theiler, Peter Jüni, Lukas P Staub, Cedric Luyet, Lorenzo Alberio, Kay Stricker and Robert Greif

    Citation: Trials 2009 10:107

    Content type: Study protocol

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  42. Clinical trials evaluating the use of hypertonic saline in the treatment of hypovolemia and head trauma suggest no survival superiority over normal saline; however subgroup analyses suggest there may be a redu...

    Authors: Laurie J Morrison, Sandro B Rizoli, Brian Schwartz, Shawn G Rhind, Merita Simitciu, Tyrone Perreira, Russell MacDonald, Anna Trompeo, Donald T Stuss, Sandra E Black, Alex Kiss and Andrew J Baker

    Citation: Trials 2009 10:105

    Content type: Study protocol

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