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  1. The Atopic Dermatitis Anti-IgE Paediatric Trial (ADAPT) is a trial to determine the clinical efficacy and safety of omalizumab for children with severe atopic eczema. This article describes the detailed statis...

    Authors: Tao Chen, Susan Chan, Gideon Lack, Suzie Cro and Victoria R. Cornelius
    Citation: Trials 2017 18:231
  2. Pruritus (itch) is a frequent, burdensome and difficult-to-treat symptom in patients with cholestasis. Fibrates are currently under investigation for the treatment of primary biliary cholangitis in patients wi...

    Authors: Ruth Bolier, Elsemieke S. de Vries, Albert Parés, Jeltje Helder, E. Marleen Kemper, Koos Zwinderman, Ronald P. Oude Elferink and Ulrich Beuers
    Citation: Trials 2017 18:230
  3. Cerebral small vessel disease is a common cause of vascular cognitive impairment in older people, with no licensed treatment. Cerebral blood flow is reduced in small vessel disease. Tadalafil is a widely presc...

    Authors: Mathilde M. H. Pauls, Natasha Clarke, Sarah Trippier, Shai Betteridge, Franklyn A. Howe, Usman Khan, Christina Kruuse, Jeremy B. Madigan, Barry Moynihan, Anthony C. Pereira, Debbie Rolfe, Egill Rostrup, Caroline E. Haig, Thomas R. Barrick, Jeremy D. Isaacs and Atticus H. Hainsworth
    Citation: Trials 2017 18:229
  4. Cancer survivors have to deal with a wide range of physical symptoms, psychological, social and existential concerns, and lifestyle issues related to cancer and its treatment. Therefore, it is essential that t...

    Authors: Anja van der Hout, Cornelia F. van Uden-Kraan, Birgit I. Witte, Veerle M. H. Coupé, Femke Jansen, C. René Leemans, Pim Cuijpers, Lonneke V. van de Poll-Franse and Irma M. Verdonck-de Leeuw
    Citation: Trials 2017 18:228
  5. Implementing the treatment arm of a clinical trial often requires changes to healthcare practices. Barriers to such changes may undermine the delivery of the treatment making it more likely that the trial will...

    Authors: Justin Presseau, Brittany Mutsaers, Ahmed A. Al-Jaishi, Janet Squires, Christopher W. McIntyre, Amit X. Garg, Manish M. Sood and Jeremy M. Grimshaw
    Citation: Trials 2017 18:227
  6. Laparoscopic Roux-en-Y gastric bypass (LRYGB) is considered the gold standard in bariatric surgery, achieving durable long-term weight loss with improvement of obesity-related comorbidities. Lately, the laparo...

    Authors: Marko Kraljević, Tarik Delko, Thomas Köstler, Elena Osto, Thomas Lutz, Sarah Thommen, Raoul A. Droeser, Lincoln Rothwell, Daniel Oertli and Urs Zingg
    Citation: Trials 2017 18:226
  7. Effective interventions for young adults with severe, multiple problems – such as psychosocial and psychiatric problems, delinquency, unemployment and substance use – are scarce but urgently needed in order to...

    Authors: Marie-Jolette A. Luijks, Floor Bevaart, Josjan Zijlmans, Laura van Duin, Reshmi Marhe, Theo A. H. Doreleijers, Henning Tiemeier, Jessica J. Asscher and Arne Popma
    Citation: Trials 2017 18:225
  8. Severe limb ischaemia (SLI) is defined as the presence of rest pain and/or tissue loss secondary to lower extremity atherosclerotic peripheral arterial disease. The superficial femoral and popliteal arteries a...

    Authors: Benjamin D. Hunt, Matthew A. Popplewell, Huw Davies, Lewis Meecham, Hugh Jarrett, Gareth Bate, Margaret Grant, Smitaa Patel, Catherine Hewitt, Lazaros Andronis, Jonathan J. Deeks and Andrew Bradbury
    Citation: Trials 2017 18:224
  9. The ability to appraise claims about the benefits and harms of treatments is crucial for informed health care decision-making. This research aims to enable children in East African primary schools (the cluster...

    Authors: Allen Nsangi, Daniel Semakula, Andrew D. Oxman, Matthew Oxman, Sarah Rosenbaum, Astrid Austvoll-Dahlgren, Laetitia Nyirazinyoye, Margaret Kaseje, Iain Chalmers, Atle Fretheim and Nelson K. Sewankambo
    Citation: Trials 2017 18:223
  10. According to the Global Diabetes Plan, a unified health system with preventive and educational strategies is essential to proper diabetes care and primary settings should be the main site of care. In Brazil, t...

    Authors: Ana Marina Moreira, Roberta Marobin, Dimitris Varvaki Rados, Camila Bergonsi de Farias, Sabrina Coelli, Bárbara Luiza Bernardi, Lívia de Almeida Faller, Laura Ferraz dos Santos, Ana Maria Matzenbacher, Natan Katz, Erno Harzheim and Sandra Pinho Silveiro
    Citation: Trials 2017 18:222
  11. Older adults are the fastest growing segment of the world‘s population. Recent evidence indicates that excessive sitting time is harmful to health, independent of meeting the recommended moderate to vigorous p...

    Authors: Maria Giné-Garriga, Laura Coll-Planas, Míriam Guerra, Àlex Domingo, Marta Roqué, Paolo Caserotti, Michael Denkinger, Dietrich Rothenbacher, Mark A. Tully, Frank Kee, Emma McIntosh, Carme Martín-Borràs, Guillermo R. Oviedo, Javier Jerez-Roig, Marta Santiago, Oriol Sansano…
    Citation: Trials 2017 18:221
  12. A pragmatic, stepped wedge trial design can be an appealing design to evaluate complex interventions in real-life settings. However, there are certain pitfalls that need to be considered. This paper reports on...

    Authors: Noor Heim, Henk F. van Stel, Roelof G. Ettema, Roos C. van der Mast, Sharon K. Inouye and Marieke J. Schuurmans
    Citation: Trials 2017 18:220
  13. When designing and analysing clinical trials, using previous relevant information, perhaps in the form of evidence syntheses, can reduce research waste. We conducted the INVEST (INVestigating the use of Eviden...

    Authors: Gemma L. Clayton, Isabelle L. Smith, Julian P. T. Higgins, Borislava Mihaylova, Benjamin Thorpe, Robert Cicero, Kusal Lokuge, Julia R. Forman, Jayne F. Tierney, Ian R. White, Linda D. Sharples and Hayley E. Jones
    Citation: Trials 2017 18:219
  14. One of the most difficult symptoms for persons with sickle cell disease (SCD) to manage is chronic pain. Chronic pain impacts approximately one-third of persons with SCD and is associated with increased pain i...

    Authors: Hants Williams, Susan Silva, Leigh Ann Simmons and Paula Tanabe
    Citation: Trials 2017 18:218
  15. Extended brief interventions (EBIs) are effective in targeting alcohol misuse in the general population. However, little is known of the effects of EBI in adults with intellectual (also known as learning) disa...

    Authors: Christos Kouimtsidis, Alessandro Bosco, Katrina Scior, Gianluca Baio, Rachael Hunter, Vittoria Pezzoni, Eileen Mcnamara and Angela Hassiotis
    Citation: Trials 2017 18:216
  16. Depression has become one of the leading contributors to the global disease burden. Evidence-based treatments for depression are available, but access to them is still limited in some instances. As technology ...

    Authors: Cezar Giosan, Oana Cobeanu, Cristina MogoaÅŸe, Aurora Szentagotai, Vlad MureÅŸan and RareÈ™ Boian
    Citation: Trials 2017 18:215
  17. Fatigue is one of the most prevalent and burdensome symptoms for patients with inflammatory bowel disease (IBD). Although fatigue increases during periods of inflammation, for some patients it persists when di...

    Authors: Micol Artom, Wladyslawa Czuber-Dochan, Jackie Sturt and Christine Norton
    Citation: Trials 2017 18:213
  18. Surgery for colorectal cancer is associated with a high risk of post-operative adverse events, re-operations and a prolonged post-operative recovery. Previously, the effect of prehabilitation (pre-operative ph...

    Authors: Aron Onerup, Eva Angenete, David Bock, Mats Börjesson, Monika Fagevik Olsén, Elin Grybäck Gillheimer, Stefan Skullman, Sven-Egron Thörn, Eva Haglind and Hanna Nilsson
    Citation: Trials 2017 18:212

    The Correction to this article has been published in Trials 2020 21:1030

  19. Denture-related erythematous stomatitis (DES) is a chronic biofilm-mediated disease, affecting one in every three complete denture wearers. Antifungals are the treatment most commonly prescribed by oral health...

    Authors: Raphael F. de Souza, Muhammad Faheem Khiyani, Carolina A. L. Chaves, Jocelyne Feine, Jean Barbeau, Ramón Fuentes, Eduardo Borie, Luciana C. Crizostomo, Claudia H. Silva-Lovato, Pierre Rompre and Elham Emami
    Citation: Trials 2017 18:211
  20. Pregnant women with depression and/or anxiety prior to pregnancy are at higher risk of preterm birth, breastfeeding problems, postpartum depression, and disruption of the mother-infant attachment. It is well d...

    Authors: Lotte Broberg, Mette Backhausen, Peter Damm, Per Bech, Ann Tabor and Hanne Kristine Hegaard
    Citation: Trials 2017 18:210
  21. Depressive disorders are one of the leading causes of disease and disability worldwide. In Vietnam, although epidemiological evidence suggests that depression rates are on par with global averages, services fo...

    Authors: Jill Murphy, Charles H. Goldsmith, Wayne Jones, Pham Thi Oanh and Vu Cong Nguyen
    Citation: Trials 2017 18:209
  22. The efficacy of dual-chamber cardiac pacing in neuro-mediated reflex syncope with a cardio-inhibitory response to the Tilt-Table test (TT) has not been definitively assessed so far. The lack of reproducibility...

    Authors: Michele Brignole, Marco Tomaino, Arnaud Aerts, Fabrizio Ammirati, Félix Alejandro Ayala-Paredes, Jean-Claude Deharo, Attilio Del Rosso, Mohamed H. Hamdan, Maurizio Lunati, Angel Moya and Alessio Gargaro
    Citation: Trials 2017 18:208

    The Erratum to this article has been published in Trials 2017 18:269

  23. Up to a third of patients presenting medically unexplained physical symptoms in primary care may have a somatoform disorder, of which undifferentiated somatoform disorder (USD) is the most common type. Psychol...

    Authors: Kate Sitnikova, Stephanie S. Leone, Lyonne N. L. Zonneveld, Harm W. J. van Marwijk, Judith E. Bosmans, Johannes C. van der Wouden and Henriëtte E. van der Horst
    Citation: Trials 2017 18:206
  24. This study aimed to evaluate the quality of reports about randomized controlled trials (RCTs) of scalp acupuncture (SA) for the treatment of vascular dementia (VD).

    Authors: Young-Nim You, Myung-Rae Cho, Ju-Hyung Park, Gwang-Cheon Park, Min-Yeong Song, Jin-Bong Choi, Chang-Su Na, Jae-Young Han, Jeong-cheol Shin and Jae-Hong Kim
    Citation: Trials 2017 18:205
  25. If the randomisation process within a trial is subverted, this can lead to selection bias that may invalidate the trial’s result. To avoid this problem, it is recommended that some form of concealment should b...

    Authors: Andrew D. M. Kennedy, David J. Torgerson, Marion K. Campbell and Adrian M. Grant
    Citation: Trials 2017 18:204
  26. The costs of medical research are a concern. Clinical Trials Units (CTUs) need to better understand variations in the costs of their activities.

    Authors: Daniel Hind, Barnaby C. Reeves, Sarah Bathers, Christopher Bray, Andrea Corkhill, Christopher Hayward, Lynda Harper, Vicky Napp, John Norrie, Chris Speed, Liz Tremain, Nicola Keat and Mike Bradburn
    Citation: Trials 2017 18:203
  27. Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improv...

    Authors: T. Bluth, R. Teichmann, T. Kiss, I. Bobek, J. Canet, G. Cinnella, L. De Baerdemaeker, C. Gregoretti, G. Hedenstierna, S. N. Hemmes, M. Hiesmayr, M. W. Hollmann, S. Jaber, J. G. Laffey, M. J. Licker, K. Markstaller…
    Citation: Trials 2017 18:202

    The Erratum to this article has been published in Trials 2017 18:247

  28. Fibrotic interstitial lung diseases (ILDs) are chronic and often progressive conditions resulting in substantial morbidity and mortality. Shortness of breath, a symptom often linked to oxygen desaturation on e...

    Authors: Dina Visca, Vicky Tsipouri, Letizia Mori, Ashi Firouzi, Sharon Fleming, Morag Farquhar, Elizabeth Leung, Toby M. Maher, Paul Cullinan, Nick Hopkinson, Athol U. Wells, Winston Banya, Jennifer A. Whitty, Huzaifa Adamali, Lisa G. Spencer, Piersante Sestini…
    Citation: Trials 2017 18:201
  29. Patients with lymphoma are at risk of experiencing adverse physical and psychosocial problems from their cancer and its treatment. Regular screening of these symptoms by the use of patient-reported outcomes (P...

    Authors: Lindy P. J. Arts, Lonneke V. van de Poll-Franse, Sanne W. van den Berg, Judith B. Prins, Olga Husson, Floortje Mols, Angelique V. M. Brands-Nijenhuis, Lidwine Tick and Simone Oerlemans
    Citation: Trials 2017 18:199
  30. This article describes the design of a parallel-group, participant- and assessor-blinded randomised controlled trial comparing the effectiveness of shoe-stiffening inserts versus sham shoe insert(s) for reduci...

    Authors: Shannon E. Munteanu, Karl B. Landorf, Jodie A. McClelland, Edward Roddy, Flavia M. Cicuttini, Alan Shiell, Maria Auhl, Jamie J. Allan, Andrew K. Buldt and Hylton B. Menz
    Citation: Trials 2017 18:198
  31. Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and mortality worldwide. It is often undiagnosed and insufficiently managed. Effective forms of continuing medical education (CME) fo...

    Authors: Hanna Sandelowsky, Ingvar Krakau, Sonja Modin, Björn Ställberg and Anna Nager
    Citation: Trials 2017 18:197
  32. The Cord Pilot Trial compared alternative policies for timing of cord clamping at very preterm birth at eight UK hospitals. Preterm birth can be rapid and unexpected, allowing little time for the usual consent...

    Authors: Celine Y. Chhoa, Alexandra Sawyer, Susan Ayers, Angela Pushpa-Rajah and Lelia Duley
    Citation: Trials 2017 18:196
  33. The incidence of epilepsy is greatest in the first 2 years of life, an age group where there is generally a poor prognosis for both seizure control and neurodevelopmental outcome. Early control of seizures can...

    Authors: Siobhan Titre-Johnson, Natasha Schoeler, Christin Eltze, Ruth Williams, Katharina Vezyroglou, Helen McCullagh, Nick Freemantle, Simon Heales, Rachel Kneen, Louise Marston, Tim Martland, Irwin Nazareth, Elizabeth Neal, Andrew Lux, Alasdair Parker, Shakti Agrawal…
    Citation: Trials 2017 18:195
  34. Mindfulness-based approaches for adults are effective at enhancing mental health, but few controlled trials have evaluated their effectiveness or cost-effectiveness for young people. The primary aim of this tr...

    Authors: Willem Kuyken, Elizabeth Nuthall, Sarah Byford, Catherine Crane, Tim Dalgleish, Tamsin Ford, Mark T. Greenberg, Obioha C. Ukoumunne, Russell M. Viner and J. Mark G. Williams
    Citation: Trials 2017 18:194

    The Update to this article has been published in Trials 2021 22:254

  35. Authors: U. Teichgräber, R. Aschenbach, D. Scheinert, T. Zeller, K. Brechtel, M. Thieme, E. Blessing, M. Treitl, M. Lichtenberg, P. von Flotow, B. Vogel, M. Werk, V. Riambau, A. Wienke, T. Lehmann and S. Sixt
    Citation: Trials 2017 18:193

    The original article was published in Trials 2016 17:528

  36. Muscle mass and strength are strong determinants of a person’s quality of life and functional independence with advancing age. While resistance training is the most effective intervention to combat age-associa...

    Authors: Doug E. Long, Bailey D. Peck, Jenny L. Martz, S. Craig Tuggle, Heather M. Bush, Gerald McGwin, Philip A. Kern, Marcas M. Bamman and Charlotte A. Peterson
    Citation: Trials 2017 18:192
  37. We conducted a prospective randomized study of an adjuvant oxaliplatin-based regimen plus orally administered tegafur-uracil in patients with stage III colon cancer after radical resection to evaluate the feas...

    Authors: Yung-Sung Yeh, Hsiang-Lin Tsai, Ching-Wen Huang, Po-Li Wei, Yung-Chuan Sung, Hsiu-Chih Tang and Jaw-Yuan Wang
    Citation: Trials 2017 18:191
  38. The impact of humanitarian disasters upon mental health is well recognised. The evidence for psychological interventions for mental health is mounting, but few interventions have been rigorously tested in huma...

    Authors: Anna Chiumento, Syed Usman Hamdani, Muhammad Naseem Khan, Katie Dawson, Richard A. Bryant, Marit Sijbrandij, Huma Nazir, Parveen Akhtar, Aqsa Masood, Duolao Wang, Mark van Ommeren and Atif Rahman
    Citation: Trials 2017 18:190
  39. Intravenous administration of fluids is an essential part of critical care. While some fluid administration is likely beneficial, there is increasing observational evidence that the development of fluid overlo...

    Authors: Rasmus E. Berthelsen, Theis Itenov, Anders Perner, Jens-Ulrik Jensen, Michael Ibsen, Andreas Emil Kryger Jensen and Morten Bestle
    Citation: Trials 2017 18:189
  40. Conventional moxibustion is a representative non-drug intervention in traditional Chinese medicine, and it has been reported to produce encouraging results and benefits in relieving symptoms and improving the ...

    Authors: Lin-lin Zhu, Jian-ying Zhou, Ling Luo, Xiang Wang, Jia-xi Peng, Sha-sha Chen, Hai-Yan Yin, Qiao-Feng Wu, Cheng-shun Zhang, Peng Lv, Yong Tang and Shu-guang Yu
    Citation: Trials 2017 18:188
  41. Vitamin B12 deficiency is one of the most common micronutrient deficiencies and is associated with poor cognitive development and growth. Vitamin B12 is crucial for normal cell division and differentiation, and i...

    Authors: Tor A. Strand, Manjeswori Ulak, Ram K. Chandyo, Ingrid Kvestad, Mari Hysing, Merina Shrestha, Sudha Basnet, Suman Ranjitkar, Laxman Shrestha and Prakash S. Shrestha
    Citation: Trials 2017 18:187
  42. Innovative strategies are required to improve access to evidence-based tinnitus interventions. A guided Internet-based cognitive behavioural therapy (iCBT) intervention for tinnitus was therefore developed for...

    Authors: Eldré W. Beukes, David M. Baguley, Peter M. Allen, Vinaya Manchaiah and Gerhard Andersson
    Citation: Trials 2017 18:186
  43. Chemotherapy-induced nausea and vomiting (CINV) is one of the most common and distressing side effects in patients with cancer. The introduction and development of antiemetic drugs have significantly improved ...

    Authors: Qi-wei Li, Ming-wei Yu, Guo-wang Yang, Xiao-min Wang, Huan Wang, Chen-xi Zhang, Na Xue, Wei-ru Xu, Qi Fu, Zhong Yang and Lin Yang
    Citation: Trials 2017 18:185
  44. Lower back pain is a global health issue affecting approximately 80% of people at some stage in their life. The current literature suggests that any exercise is beneficial for reducing back pain. However, as p...

    Authors: Katherine J. Simson, Clint T. Miller, Jon Ford, Andrew Hahne, Luana Main, Timo Rantalainen, Wei-Peng Teo, Megan Teychenne, David Connell, Guy Trudel, Guoyan Zheng, Gary Thickbroom and Daniel L. Belavy
    Citation: Trials 2017 18:184
  45. Postoperative cancer recurrence is a major problem following curative surgery. In a previous retrospective study of lung cancer surgery, we reported that administration of atrial natriuretic peptide (ANP) duri...

    Authors: Takashi Nojiri, Haruko Yamamoto, Toshimitsu Hamasaki, Kaori Onda, Kikuko Ohshima, Yasushi Shintani, Meinoshin Okumura and Kenji Kangawa
    Citation: Trials 2017 18:183
  46. As life expectancy increases and the number of older people, particularly those aged 85 years and over, expands there is an increase in demand for long-term care. A large proportion of people in a care home se...

    Authors: Anne Forster, Jennifer Airlie, Karen Birch, Robert Cicero, Bonnie Cundill, Alison Ellwood, Mary Godfrey, Liz Graham, John Green, Claire Hulme, Rebecca Lawton, Vicki McLellan, Nicola McMaster and Amanda Farrin
    Citation: Trials 2017 18:182

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