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Page 120 of 129

  1. The purpose of the study was to evaluate systematic reviews of research into two public health priorities, tobacco consumption and HIV infection, in terms of the reporting of data related to the applicability ...

    Authors: Nizar Ahmad, Isabelle Boutron, Agnès Dechartres, Pierre Durieux and Philippe Ravaud

    Citation: Trials 2010 11:20

    Content type: Research

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  2. Depression frequently occurs in the elderly and in patients suffering from dementia. Its cause is largely unknown, but several studies point to a possible contribution of circadian rhythm disturbances. Post-mo...

    Authors: Els IS Most, Philip Scheltens and Eus JW Van Someren

    Citation: Trials 2010 11:19

    Content type: Study protocol

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  3. Borderline Personality Disorder (BPD) is a common mental disorder associated with raised mortality, morbidity and substantial economic costs. Although complex psychological interventions have been shown to be ...

    Authors: Paul Moran, Rohan Borschmann, Clare Flach, Barbara Barrett, Sarah Byford, Joanna Hogg, Morven Leese, Kim Sutherby, Claire Henderson, Diana Rose, Mike Slade, George Szmukler and Graham Thornicroft

    Citation: Trials 2010 11:18

    Content type: Study protocol

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  4. Enrolment of patients into a randomised controlled trial (RCT) in violation of key inclusion or exclusion criteria, may lead to excess avoidable harm. The purpose of this paper was to systematically identify a...

    Authors: Fiona Simpson, Elizabeth A Sweetman and Gordon S Doig

    Citation: Trials 2010 11:17

    Content type: Research

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  5. Earlier diagnosis followed by multi-factorial cardiovascular risk intervention may improve outcomes in Type 2 Diabetes Mellitus (T2DM). Latent phase identification through screening requires structured, approp...

    Authors: DR Webb, K Khunti, B Srinivasan, LJ Gray, N Taub, S Campbell, J Barnett, J Henson, S Hiles, A Farooqi, SJ Griffin, NJ Wareham and MJ Davies

    Citation: Trials 2010 11:16

    Content type: Study protocol

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  6. Various treatment options for the prosthetic treatment of jaws where all molars are lost are under discussion. Besides the placement of implants, two main treatment types can be distinguished: replacement of t...

    Authors: Ralph G Luthardt, Birgit Marré, Achim Heinecke, Joachim Gerss, Hans Aggstaller, Eckhard Busche, Paul Dressler, Ingrid Gitt, Wolfgang Hannak, Sinsa Hartmann, Guido Heydecke, Florentine Jahn, Matthias Kern, Torsten Mundt, Peter Pospiech, Helmut Stark…

    Citation: Trials 2010 11:15

    Content type: Study protocol

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  7. Previous research has shown the oxidizing properties and microbiological efficacies of chlorine dioxide (ClO2). Its clinical efficacies on oral malodor have been evaluated and reported only in short duration tria...

    Authors: Kayoko Shinada, Masayuki Ueno, Chisato Konishi, Sachiko Takehara, Sayaka Yokoyama, Takashi Zaitsu, Mari Ohnuki, Fredrick Allan Clive Wright and Yoko Kawaguchi

    Citation: Trials 2010 11:14

    Content type: Research

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  8. The National Dementia Strategy seeks to enhance general practitioners' diagnostic and management skills in dementia. Early diagnosis in dementia within primary care is important as this allows those with demen...

    Authors: Steve Iliffe, Jane Wilcock, Mark Griffin, Priya Jain, Ingela Thuné-Boyle, Tamar Koch and Frances Lefford

    Citation: Trials 2010 11:13

    Content type: Study protocol

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  9. Verrucae are a common, infectious and sometimes painful problem. The optimal treatment for verrucae is unclear due to a lack of high quality randomised controlled trials. The primary objective of this study is...

    Authors: E Sarah Cockayne

    Citation: Trials 2010 11:12

    Content type: Study protocol

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  10. There are controversies about the most effective treatment to eradicate first growth of Pseudomonas aeruginosa (P aeruginosa) from the lower airways of patients with cystic fibrosis (CF). UK guidelines recommend ...

    Authors: Helen R Hickey, Ashley P Jones, Warren Lenney, Paula R Williamson and Rosalind L Smyth

    Citation: Trials 2010 11:11

    Content type: Research

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  11. Performance of primary school students in India lags far below government expectations, and major disparity exists between rural and urban areas. The Naandi Foundation has designed and implemented a programme ...

    Authors: Alex Eble, Vera Mann, Preetha Bhakta, Rashmi Lakshminarayana, Chris Frost, Diana Elbourne and Peter Boone

    Citation: Trials 2010 11:10

    Content type: Study protocol

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  12. In recognition of the benefits of transparent reporting, many peer-reviewed journals require that their authors be prepared to share their raw, unprocessed data with other scientists and/or state the availabil...

    Authors: Iain Hrynaszkiewicz, Melissa L Norton, Andrew J Vickers and Douglas G Altman

    Citation: Trials 2010 11:9

    Content type: Editorial

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  13. Depression is a leading cause of disability worldwide and depressive symptoms are common in later life. Observational evidence suggests that depression is more prevalent among people with high plasma homocyste...

    Authors: Andrew H Ford, Leon Flicker, Kieran McCaul, Frank van Bockxmeer, Sarah Hegarty, Varsha Hirani, Stephen Fenner and Osvaldo P Almeida

    Citation: Trials 2010 11:8

    Content type: Study protocol

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  14. New Zealand has relatively high rates of morbidity and mortality from infectious disease compared with other OECD countries, with infectious disease being more prevalent in children compared with others in the...

    Authors: Joanne E McKenzie, Patricia Priest, Rick Audas, Marion R Poore, Cheryl R Brunton and Lesley M Reeves

    Citation: Trials 2010 11:7

    Content type: Study protocol

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  15. Regular physical activity reduces the risk of mortality from all causes, with a powerful beneficial effect on risk of falls and hip fractures. However, physical activity levels are low in the older population ...

    Authors: Steve Iliffe, Denise Kendrick, Richard Morris, Dawn Skelton, Heather Gage, Susie Dinan, Zoe Stevens, Mirilee Pearl and Tahir Masud

    Citation: Trials 2010 11:6

    Content type: Study protocol

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  16. Acute coronary syndromes, including myocardial infarction and unstable angina, are important causes of premature mortality, morbidity and hospital admissions. Acute coronary syndromes consume large amounts of ...

    Authors: Marcus D Flather, Jean Booth, Daphne Babalis, Hector Bueno, Philippe G Steg, Grzegorz Opolski, Filippo Ottani, Jacques Machecourt, Alfredo Bardaji, Mats Bojestig, Anthony R Brady and Bertil Lindahl

    Citation: Trials 2010 11:5

    Content type: Study protocol

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  17. The primary aim of this study was to compare the efficacy of three physical activity (PA) behavioural intervention strategies in a sample of adults with type 2 diabetes.

    Authors: Ronald C Plotnikoff, Kerry S Courneya, Ronald J Sigal, Jeffrey A Johnson, Nicholas Birkett, David Lau, Kim Raine, Steven T Johnson and Nandini Karunamuni

    Citation: Trials 2010 11:4

    Content type: Study protocol

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  18. Marfan syndrome (MFS) is one of the most common systemic disorders of connective tissue with the incidence of approximately 2-3 per 10 000 individuals. Aortic disease, leading to progressive aneurysmal dilatat...

    Authors: Teodora Radonic, Piet de Witte, Marieke JH Baars, Aeilko H Zwinderman, Barbara JM Mulder and Maarten Groenink

    Citation: Trials 2010 11:3

    Content type: Study protocol

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  19. Paclitaxel-eluting stents decrease angiographic and clinical restenosis following percutaneous coronary intervention compared to bare metal stents. TAXUS Element is a third-generation paclitaxel-eluting stent ...

    Authors: Dominic J Allocco, Louis A Cannon, Amy Britt, John E Heil, Andrey Nersesov, Scott Wehrenberg, Keith D Dawkins and Dean J Kereiakes

    Citation: Trials 2010 11:1

    Content type: Study protocol

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  20. Experts in Traditional Chinese Medicine (TCM) have studied the TCM subject of the pathogenesis of heart failure (HF) for several decades. As a result, the general idea is ben deficiency and biao excess. However, ...

    Authors: Jingyuan Mao, Yazhu Hou, Hongcai Shang, Henghe Wang, Xianliang Wang, Yingqiang Zhao, Tianfu Niu, Jinrong Cui, Guangping Li, Qian Lin, Le Shi, Xiuli Jia, Ruihong Fan, Baohe Wang, Hongwu Wang and Jishou Ruan

    Citation: Trials 2009 10:122

    Content type: Study protocol

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  21. The standard of care for metastatic gastric cancer (MGC) is systemic chemotherapy which leads to a median survival of 6-15 months. Survival beyond 3 years is rare. For selected groups of patients with limited ...

    Authors: Sid P Kerkar, Clinton D Kemp, Austin Duffy, Udai S Kammula, David S Schrump, King F Kwong, Martha Quezado, Barry R Goldspiel, Aradhana Venkatesan, Ann Berger, Melissa Walker, Mary Ann Toomey, Seth M Steinberg, Guiseppe Giaccone, Steven A Rosenberg and Itzhak Avital

    Citation: Trials 2009 10:121

    Content type: Study protocol

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  22. The implantable cardioverter defibrillator (ICD) is generally well accepted, but 25-33% of patients experience clinical levels of anxiety, depression, and impaired quality of life (QoL) following implantation....

    Authors: Susanne S Pedersen, Viola Spek, Dominic AMJ Theuns, Marco Alings, Pepijn van der Voort, Luc Jordaens, Pim Cuijpers, Johan Denollet and Krista C van den Broek

    Citation: Trials 2009 10:120

    Content type: Study protocol

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  23. Coronary artery disease is the leading cause of morbidity and mortality in patients with type 2 diabetes. Screening for asymptomatic coronary artery disease with treatment by means of revascularization seems t...

    Authors: Fabrizio Turrini, Roberto Messora, Paolo Giovanardi, Stefano Tondi, Paolo Magnavacchi, Rita Cavani, Giandomenico Tosoni, Carlo Cappelli, Elisa Pellegrini, Stefania Romano, Augusto Baldini, Romeo Giulietto Zennaro and Marco Bondi

    Citation: Trials 2009 10:119

    Content type: Study protocol

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  24. Modern radiotherapy plays an important role in therapy of advanced head and neck carcinomas. However, no clinical studies have been published addressing the effectiveness of postoperative radiotherapy in patie...

    Authors: Maximilian Moergel, Antje Jahn-Eimermacher, Frank Krummenauer, Torsten E Reichert, Wilfried Wagner, Thomas G Wendt, Jochen A Werner and Bilal Al-Nawas

    Citation: Trials 2009 10:118

    Content type: Study protocol

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  25. Research evidence from observational studies suggests that cognitive activity reduces the risk of cognitive impairment in later life as well as the rate of cognitive decline of people with dementia. The Promot...

    Authors: Mandy R Vidovich, Nicola T Lautenschlager, Leon Flicker, Linda Clare and Osvaldo P Almeida

    Citation: Trials 2009 10:114

    Content type: Study protocol

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  26. Bisphosphonates can reduce fracture risk in patients with osteoporosis, but many at-risk patients do not start or adhere to these medications. The aims of this study are to: (1) preliminarily evaluate the effe...

    Authors: Laurie J Pencille, Megan E Campbell, Holly K Van Houten, Nilay D Shah, Rebecca J Mullan, Brian A Swiglo, Maggie Breslin, Rebecca L Kesman, Sidna M Tulledge-Scheitel, Thomas M Jaeger, Ruth E Johnson, Gregory A Bartel, Robert A Wermers, L Joseph Melton III and Victor M Montori

    Citation: Trials 2009 10:113

    Content type: Study protocol

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  27. Dry eye is usually managed by conventional medical interventions such as artificial tears, anti-inflammatory drugs and surgical treatment. However, since dry eye is one of the most frequent ophthalmologic diso...

    Authors: Tae-Hun Kim, Jong-In Kim, Mi-Suk Shin, Myeong Soo Lee, Jun-Yong Choi, So-Yong Jung, Ae-Ran Kim, Jae-Uk Seol and Sun-Mi Choi

    Citation: Trials 2009 10:112

    Content type: Study protocol

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  28. A response to the letter regarding The BRAIN TRIAL: a randomized, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury, by Mr Vincent Simmon Presi...

    Authors: Ian Roberts and Haleema Shakur

    Citation: Trials 2009 10:111

    Content type: Letter

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  29. A response to and comment on The BRAIN TRIAL: a randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury, by Haleema Shakur, Ian Roberts, et ...

    Authors: Vincent F Simmon

    Citation: Trials 2009 10:110

    Content type: Letter

    Published on:

  30. Cerebral oedema is associated with significant neurological damage in patients with traumatic brain injury. Bradykinin is an inflammatory mediator that may contribute to cerebral oedema by increasing the perme...

    Authors: Haleema Shakur, Peter Andrews, Toomas Asser, Laura Balica, Cristian Boeriu, Juan Diego Ciro Quintero, Yashbir Dewan, Patrick Druwé, Olivia Fletcher, Chris Frost, Bennie Hartzenberg, Jorge Mejia Mantilla, Francisco Murillo-Cabezas, Jan Pachl, Ramalingam R Ravi, Indrek Rätsep…

    Citation: Trials 2009 10:109

    Content type: Research

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  31. The UK has a strong tradition of innovative evaluative health care research. There are, however, considerable forces impeding collaboration between clinicians, academics, patients and their advocates and indus...

    Authors: Clive E Adams and Mauricio Silva de Lima

    Citation: Trials 2009 10:108

    Content type: Commentary

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  32. Bleeding is a frequent complication during surgery. The intraoperative administration of blood products, including packed red blood cells, platelets and fresh frozen plasma (FFP), is often live saving. Complic...

    Authors: Natalie Urwyler, Sven Trelle, Lorenz Theiler, Peter Jüni, Lukas P Staub, Cedric Luyet, Lorenzo Alberio, Kay Stricker and Robert Greif

    Citation: Trials 2009 10:107

    Content type: Study protocol

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  33. Clinical trials evaluating the use of hypertonic saline in the treatment of hypovolemia and head trauma suggest no survival superiority over normal saline; however subgroup analyses suggest there may be a redu...

    Authors: Laurie J Morrison, Sandro B Rizoli, Brian Schwartz, Shawn G Rhind, Merita Simitciu, Tyrone Perreira, Russell MacDonald, Anna Trompeo, Donald T Stuss, Sandra E Black, Alex Kiss and Andrew J Baker

    Citation: Trials 2009 10:105

    Content type: Study protocol

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  34. Preeclampsia (PE) is a common maternal disease that complicates 5 to 10% of pregnancies and remains as the major cause of maternal and neonatal mortality. Cost-effective interventions aimed at preventing the d...

    Authors: Robinson Ramírez-Vélez, Ana C Aguilar, Mildrey Mosquera, Ronald G Garcia, Laura M Reyes and Patricio López-Jaramillo

    Citation: Trials 2009 10:104

    Content type: Study protocol

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  35. Exercise therapies generate substantial costs in computer workers with non-specific work-related upper limb disorders (WRULD).

    Authors: Marjon D van Eijsden, Sylvia A Gerhards, Rob A de Bie and Johan L Severens

    Citation: Trials 2009 10:103

    Content type: Research

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  36. Idiopathic recurrent miscarriage is defined as 3 consecutive pregnancy losses with no contributing features found on investigations. At present there are no treatments of proven efficacy for idiopathic recurre...

    Authors: Ai-Wei Tang, Zarko Alfirevic, Mark A Turner, Jo Drury and Siobhan Quenby

    Citation: Trials 2009 10:102

    Content type: Study protocol

    Published on:

  37. Subgroup analyses in randomized trials examine whether effects of interventions differ between subgroups of study populations according to characteristics of patients or interventions. However, findings from s...

    Authors: Xin Sun, Matthias Briel, Jason W Busse, Elie A Akl, John J You, Filip Mejza, Malgorzata Bala, Natalia Diaz-Granados, Dirk Bassler, Dominik Mertz, Sadeesh K Srinathan, Per Olav Vandvik, German Malaga, Mohamed Alshurafa, Philipp Dahm, Pablo Alonso-Coello…

    Citation: Trials 2009 10:101

    Content type: Study protocol

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  38. With 2.5 million new HIV infections per year, effective preventive methods against HIV are urgently needed, especially in sub-Saharan Africa. MDP301 is an ongoing trial of the vaginal microbicide PRO 2000/5 be...

    Authors: Andrew Nunn, Sheena McCormack, Angela M Crook, Robert Pool, Clare Rutterford and Richard Hayes

    Citation: Trials 2009 10:99

    Content type: Study protocol

    Published on:

  39. Previous randomized trials have showed the superiority of Paclitaxel-eluting stent over bare metal stent in angiographic and clinical outcomes. Coroflex Please™ stent is a newly developed drug eluting stent us...

    Authors: Jae-Bin Seo, Hui-Kyung Jeon, Kyung-Woo Park, Jong-Seon Park, Jang-Ho Bae, Sang-Wook Kim, Keon-Woong Moon, Jae-Woong Choi, Sang-Gon Lee, Woo-Young Chung, Tae-Jin Youn, Soo-Joong Kim, Doo-Il Kim, Byung-Ok Kim, Min-Su Hyon, Keum-Soo Park…

    Citation: Trials 2009 10:98

    Content type: Study protocol

    Published on:

  40. Two different approaches have been adopted when applying motor imagery (MI) to stroke patients. MI can be conducted either added to conventional physiotherapy or integrated within therapy sessions. The propose...

    Authors: Corina Schuster, Jenny Butler, Brian Andrews, Udo Kischka and Thierry Ettlin

    Citation: Trials 2009 10:97

    Content type: Study protocol

    Published on:

  41. Chronic back pain is a major public health problem and the primary reason patients seek massage treatment. Despite the growing use of massage for chronic low back pain, there have been few studies of its effec...

    Authors: Daniel C Cherkin, Karen J Sherman, Janet Kahn, Janet H Erro, Richard A Deyo, Sebastien J Haneuse and Andrea J Cook

    Citation: Trials 2009 10:96

    Content type: Study protocol

    Published on:

  42. Thorough knowledge of the regulatory requirements is a challenging prerequisite for conducting multinational clinical studies in Europe given their complexity and heterogeneity in regulation and perception acr...

    Authors: Christine Kubiak, Fernando de Andres-Trelles, Wolfgang Kuchinke, Karl-Heinz Huemer, Steffen Thirstrup, Kate Whitfield, Christian Libersa, Béatrice Barraud, Xina Grählert, Gabriele Dreier, Ruth Grychtol, Zsuzsa Temesvari, Gyorgy Blasko, Gabriella Kardos, Timothy O'Brien, Margaret Cooney…

    Citation: Trials 2009 10:95

    Content type: Research

    Published on:

  43. Intraoperative haemorrhage is a known predictor for perioperative outcome of patients undergoing hepatic resection. While anaesthesiological lowering of central venous pressure (CVP) by fluid restriction is kn...

    Authors: Nuh N Rahbari, Johannes B Zimmermann, Moritz Koch, Thomas Bruckner, Thomas Schmidt, Heike Elbers, Christoph Reissfelder, Markus A Weigand, Markus W Büchler and Jürgen Weitz

    Citation: Trials 2009 10:94

    Content type: Study protocol

    Published on:

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