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  1. Postoperative atrial fibrillation (POAF) is the most common complication after coronary artery bypass grafting (CABG). The preventive effect of magnesium on POAF is not well known. This meta-analysis was under...

    Authors: Wan-Jie Gu, Zhen-Jie Wu, Peng-Fei Wang, Lynn Htet Htet Aung and Rui-Xing Yin

    Citation: Trials 2012 13:41

    Content type: Research

    Published on:

  2. The end of life for cancer patients is the ultimate stage of the disease, and care in this setting is important as it can improve the wellbeing not only of patients, but also the patients' family and close fri...

    Authors: Anne-Lise Poirier, Fabrice Kwiatkowski, Jean-Marie Commer, Bénédicte D'Aillières, Virginie Berger, Mariette Mercier and Franck Bonnetain

    Citation: Trials 2012 13:39

    Content type: Study protocol

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  3. Substantial data indicate potential health consequences of untreated postpartum depression (PPD) on the mother, infant, and family. Studies have evaluated interpersonal psychotherapy (IPT) as treatment for PPD...

    Authors: Cindy-Lee Dennis, Paula Ravitz, Sophie Grigoriadis, Melissa Jovellanos, Ellen Hodnett, Lori Ross and John Zupancic

    Citation: Trials 2012 13:38

    Content type: Study protocol

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  4. Non-allergic rhinopathy (NAR), formerly known as vasomotor rhinitis, is a non-allergic and non-infectious chronic disease that is accompanied by nasal hyperemia, rhinorrhea, and no increase in the number of eo...

    Authors: Kyu Seok Kim, Sang Gyu Go and Yoon-Bum Kim

    Citation: Trials 2012 13:37

    Content type: Study protocol

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  5. The zygoma plays an important role in the facial contour for both cosmetic and functional reasons; therefore zygomatic bone injuries should be properly diagnosed and adequately treated. Comparison of various s...

    Authors: Majeed Rana, Riaz Warraich, Salman Tahir, Asifa Iqbal, Constantin von See, André M Eckardt and Nils-Claudius Gellrich

    Citation: Trials 2012 13:36

    Content type: Research

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  6. Well-designed and properly executed randomized controlled trials (RCTs) provide the best evidence on the efficacy of healthcare interventions. Mental health has a strong tradition of using trial to evaluate tr...

    Authors: Marianna Purgato, Clive Adams and Corrado Barbui

    Citation: Trials 2012 13:35

    Content type: Research

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  7. Many older people with neuropsychiatric disorders such as Alzheimer's disease and frontotemporal dementia suffer from sleeping problems and often show nocturnal restlessness. Professionals and informal carers ...

    Authors: Arnoldien J van Os, Leelie Aziz, Dorus Schalkwijk, Jos MGA Schols and Rob A de Bie

    Citation: Trials 2012 13:34

    Content type: Study protocol

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  8. Obesity, which is described as excessive or abnormal body fat, increases the risk of diet-related diseases. In Korea and around the world, the prevalence of obesity has grown annually from 1998 to 2008. This g...

    Authors: Sunju Park, Jeong-Su Park, ChunHoo Cheon, Yong Joon Yang, Changsuk An, Bo-Hyoung Jang, Yun-Kyung Song, Hoyeon Go, Ju Ah Lee, Yongcheol Shin and Seong-Gyu Ko

    Citation: Trials 2012 13:33

    Content type: Study protocol

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  9. Almost all cognitive functions decline with age. Results of previous studies have shown that cognitive training related to everyday life (reading aloud and solving simple arithmetic calculations), namely learn...

    Authors: Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Takayuki Nozawa, Atsushi Sekiguchi, Haruka Nouchi and Ryuta Kawashima

    Citation: Trials 2012 13:32

    Content type: Study protocol

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  10. Half of all lower limb deep vein thrombi (DVT) in symptomatic ambulatory patients are located in the distal (calf) veins. While proximal disease warrants therapeutic anticoagulation to reduce the associated ri...

    Authors: Daniel Horner, Kerstin Hogg, Richard Body, Michael J Nash and Kevin Mackway-Jones

    Citation: Trials 2012 13:31

    Content type: Study protocol

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  11. Despite continual improvements in the management of acute coronary syndromes, adherence to guideline-based medications remains suboptimal. We aim to improve adherence with guideline-based therapy following acu...

    Authors: Daniel D L Bernal, Leanne Stafford, Luke R E Bereznicki, Ronald L Castelino, Patricia M Davidson and Gregory M Peterson

    Citation: Trials 2012 13:30

    Content type: Study protocol

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  12. Second-generation drug-eluting stents (DES) have raised the bar of clinical performance. These stents are mostly made from cobalt chromium alloy. A newer generation DES has been developed from platinum chromiu...

    Authors: Kyung Woo Park, Byoung-Eun Park, Si-Hyuck Kang, Jin-Joo Park, Seung-Pyo Lee, Kwang Soo Cha, Jay Young Rhew, Hui-Kyoung Jeon, Eun Seok Shin, Ju Hyeon Oh, Myung-Ho Jeong, Sanghyun Kim, Kyung-Kuk Hwang, Jung-Han Yoon, Sung Yun Lee, Tae-Ho Park…

    Citation: Trials 2012 13:29

    Content type: Study protocol

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  13. In order to facilitate multinational clinical research, regulatory requirements need to become international and harmonised. The EU introduced the Directive 2001/20/EC in 2004, regulating investigational medic...

    Authors: Christian Gluud, Christine Kubiak, Kate Whitfield, Jane Byrne, Karl-Heinz Huemer, Steffen Thirstrup, Christian Libersa, Béatrice Barraud, Xina Grählert, Gabriele Dreier, Sebastian Geismann, Wolfgang Kuchinke, Zsuza Temesvari, Gyorgy Blasko, Gabriella Kardos, Timothy O'Brien…

    Citation: Trials 2012 13:27

    Content type: Research

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  14. Approximately 80,000 patients each year are admitted to UK hospitals with an acute stroke and are immobile. At least 10% will develop a proximal Deep Vein Thrombosis in the first month and 1.5% a pulmonary emb...

    Authors: Martin Dennis, Peter Sandercock, John Reid, Catriona Graham and John Forbes

    Citation: Trials 2012 13:26

    Content type: Study protocol

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  15. An aging population and better management of various heart diseases explain the exponential growth in incidence and prevalence of chronic heart failure, with poor prognosis and heavy health costs. Medical mana...

    Authors: Romain Eschalier, Frédéric Jean, Bruno Pereira, Séverine Monzy, Charles Vorilhon, Valérie Mactoux, Bernard Citron, Vincent Sapin, Pascal Motreff and Jean R Lusson

    Citation: Trials 2012 13:25

    Content type: Study protocol

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  16. Numerous technical modifications to radical prostatectomy have been proposed. Such modifications are likely to lead to only slight improvements in outcomes. Although small differences would be worthwhile, an a...

    Authors: Andrew J Vickers, Caroline Bennette, Karim Touijer, Jonathan Coleman, Vincent Laudone, Brett Carver, James A Eastham and Peter T Scardino

    Citation: Trials 2012 13:23

    Content type: Research

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  17. Vitamin A supplementation of 6-59 month old children is currently recommended by the World Health Organization based on evidence that it reduces mortality. There has been considerable interest in determining t...

    Authors: Rajiv Bahl, Nita Bhandari, Brinda Dube, Karen Edmond, Wafaie Fawzi, Olivier Fontaine, Jasmine Kaur, Betty R Kirkwood, Jose Martines, Honorati Masanja, Sarmila Mazumder, Salum Msham, Sam Newton, Maureen Oleary, Julia Ruben, Caitlin Shannon…

    Citation: Trials 2012 13:22

    Content type: Study protocol

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  18. Central sensitization has recently been documented in patients with knee osteoarthritis (OAk). So far, the presence of central sensitization has not been considered as a confounding factor in studies assessing...

    Authors: David Beckwée, Willem De Hertogh, Pierre Lievens, Ivan Bautmans and Peter Vaes

    Citation: Trials 2012 13:21

    Content type: Study protocol

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  19. Heart failure patients with stable angina, acute coronary syndromes and valvular heart disease may benefit from revascularisation and/or valve surgery. However, the mortality rate is increased- 5-30%. Biventri...

    Authors: Stuart J Russell, Christine Tan, Peter O'Keefe, Saeed Ashraf, Afzal Zaidi, Alan G Fraser and Zaheer R Yousef

    Citation: Trials 2012 13:20

    Content type: Study protocol

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  20. Alcohol dependence is a significant and costly problem in the UK yet only 6% of people a year receive treatment. Current service provision based on the treatment of acute episodes of illness and emphasising pe...

    Authors: Helen Gilburt, Tom Burns, Alex Copello, Simon Coulton, Michael Crawford, Ed Day, Paolo Deluca, Christine Godfrey, Steve Parrott, Abigail K Rose, Julia M A Sinclair, Christine Wright and Colin Drummond

    Citation: Trials 2012 13:19

    Content type: Study protocol

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  21. The success and cost-effectiveness of bowel cancer screening depends on achieving and maintaining high screening uptake rates. The involvement of GPs in screening has been found to improve patient compliance. ...

    Authors: Sarah Damery, Steve Smith, Alison Clements, Roger Holder, Linda Nichols, Heather Draper, Sue Clifford, Laura Parker, Richard Hobbs and Sue Wilson

    Citation: Trials 2012 13:18

    Content type: Study protocol

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  22. Cricoid pressure is considered to be the gold standard means of preventing aspiration of gastric content during Rapid Sequence Intubation (RSI). Its effectiveness has only been demonstrated in cadaveric studie...

    Authors: Christopher E Trethewy, Julie M Burrows, Don Clausen and Steven R Doherty

    Citation: Trials 2012 13:17

    Content type: Study protocol

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  23. Internet-administered cognitive behavioural therapy (ICBT) has been found to be effective for a range of anxiety disorders. However, most studies have focused on one specific primary diagnosis and co-morbidity...

    Authors: Lise Bergman Nordgren, Gerhard Andersson, Åsa Kadowaki and Per Carlbring

    Citation: Trials 2012 13:16

    Content type: Study protocol

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  24. Multiple sclerosis is the most common chronic inflammatory disease of the central nervous system in young adults. Despite the fact that numerous lines of evidence link both the risk of disease development and ...

    Authors: Jan Dörr, Stephanie Ohlraun, Horst Skarabis and Friedemann Paul

    Citation: Trials 2012 13:15

    Content type: Study protocol

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  25. Incisional hernia is a frequent complication in abdominal surgery. This article describes the development of a prospective randomized clinical trial designed to determine whether watchful waiting is an accepta...

    Authors: Johannes C Lauscher, Peter Martus, Andrea Stroux, Jens Neudecker, Uwe Behrens, Ralf Hammerich, Heinz J Buhr and Jörg-Peter Ritz

    Citation: Trials 2012 13:14

    Content type: Study protocol

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  26. MAVIDOS is a randomised, double-blind, placebo-controlled trial (ISRCTN82927713, registered 2008 Apr 11), funded by Arthritis Research UK, MRC, Bupa Foundation and NIHR.

    Authors: Nicholas C Harvey, Kassim Javaid, Nicholas Bishop, Stephen Kennedy, Aris T Papageorghiou, Robert Fraser, Saurabh V Gandhi, Inez Schoenmakers, Ann Prentice and Cyrus Cooper

    Citation: Trials 2012 13:13

    Content type: Study protocol

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  27. Children who witness interparental violence are at a heightened risk for developing psychosocial, behavioral and cognitive problems, as well as posttraumatic stress symptoms. For these children the psycho-educ...

    Authors: Mathilde M Overbeek, J Clasien de Schipper, Francien Lamers-Winkelman and Carlo Schuengel

    Citation: Trials 2012 13:12

    Content type: Study protocol

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  28. Motor imagery (MI) when combined with physiotherapy can offer functional benefits after stroke. Two MI integration strategies exist: added and embedded MI. Both approaches were compared when learning a complex...

    Authors: Corina Schuster, Jenny Butler, Brian Andrews, Udo Kischka and Thierry Ettlin

    Citation: Trials 2012 13:11

    Content type: Research

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  29. Hand hygiene is considered as an important means of infection control. We explored whether guided hand hygiene together with transmission-limiting behaviour reduces infection episodes and lost days of work in ...

    Authors: Carita Savolainen-Kopra, Jaason Haapakoski, Piia A Peltola, Thedi Ziegler, Terttu Korpela, Pirjo Anttila, Ali Amiryousefi, Pentti Huovinen, Markku Huvinen, Heikki Noronen, Pia Riikkala, Merja Roivainen, Petri Ruutu, Juha Teirilä, Erkki Vartiainen and Tapani Hovi

    Citation: Trials 2012 13:10

    Content type: Research

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  30. We aimed to establish levels of consumer involvement in randomised controlled trials (RCTs), meta-analyses and other studies carried out by the UK Medical Research Council (MRC) Clinical Trials Unit across the...

    Authors: Claire L Vale, Lindsay C Thompson, Claire Murphy, Silvia Forcat and Bec Hanley

    Citation: Trials 2012 13:9

    Content type: Research

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  31. Executive function is critical for children's healthy development. We propose an intervention program to enhance children's executive function using the game, GO. Many neuroimaging studies have revealed that p...

    Authors: Yoshiyuki Tachibana, Jiro Yoshida, Masahito Ichinomiya, Rui Nouchi, Carlos Miyauchi, Hikaru Takeuchi, Naoki Tomita, Hiroyuki Arai and Ryuta Kawashima

    Citation: Trials 2012 13:8

    Content type: Study protocol

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  32. Laparoscopic cholecystectomy in acute calculous cholecystitis in high risk patients can lead to significant morbidity and mortality. Percutaneous cholecystostomy may be an alternative treatment option but the ...

    Authors: Kirsten Kortram, Bert van Ramshorst, Thomas L Bollen, Marc G H Besselink, Dirk J Gouma, Tom Karsten, Philip M Kruyt, Grard A P Nieuwenhuijzen, Johannes C Kelder, Ellen Tromp and Djamila Boerma

    Citation: Trials 2012 13:7

    Content type: Study protocol

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  33. Chronic Obstructive Pulmonary Disease (COPD) and asthma are common chronic diseases that are frequently accompanied by depression and/or anxiety. However, symptoms of depression and anxiety are often not recog...

    Authors: Antoinette M Pommer, François Pouwer, Johan Denollet and Victor J M Pop

    Citation: Trials 2012 13:6

    Content type: Study protocol

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  34. Surgeons in the Netherlands, Canada and the US participate in the FAITH trial (Fixation using Alternative Implants for the Treatment of Hip fractures). Dutch sites are managed and visited by a financed central...

    Authors: Stephanie M Zielinski, Helena Viveiros, Martin J Heetveld, Marc F Swiontkowski, Mohit Bhandari, Peter Patka and Esther MM Van Lieshout

    Citation: Trials 2012 13:5

    Content type: Research

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  35. Governments and donors all over Africa are searching for sustainable, affordable and cost-effective ways to improve the quality of malaria case management. Widespread deficiencies have been reported in the pre...

    Authors: Virginia Wiseman, Lindsay J Mangham, Bonnie Cundill, Olivia A Achonduh, Akindeh Mbuh Nji, Abanda Ngu Njei, Clare Chandler and Wilfred F Mbacham

    Citation: Trials 2012 13:4

    Content type: Study protocol

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  36. Gyejibongnyeong-hwan (GJBNH) is one of the most popular Korean medicine formulas for menstrual pain of dysmenorrhea. The concept of blood stagnation in Korean medicine is considered the main factor of causing ...

    Authors: Jeong-Su Park, Sunju Park, Chun-Hoo Cheon, Ho-Yeon Go, Seung-Ho Sun, Yong-Cheol Shin, Bo-Hyoung Jang and Seong-Gyu Ko

    Citation: Trials 2012 13:3

    Content type: Study protocol

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  37. Randomised trials evaluation of surgical interventions are often designed and analysed as if the outcome of individual patients is independent of the surgeon providing the intervention. There is reason to expe...

    Authors: Jonathan A Cook, Thomas Bruckner, Graeme S MacLennan and Christoph M Seiler

    Citation: Trials 2012 13:2

    Content type: Methodology

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  38. Patients with ST-elevation myocardial infarction (STEMI) not treated with primary or rescue percutaneous coronary intervention (PCI) are at risk for recurrent ischemia, especially when viability in the infarct...

    Authors: Ramon B van Loon, Gerrit Veen, Leo H B Baur, Otto Kamp, Jean G F Bronzwaer, Jos W R Twisk, Freek W A Verheugt and Albert C van Rossum

    Citation: Trials 2012 13:1

    Content type: Research

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  39. Fresh frozen plasma (FFP) is an effective therapy to correct for a deficiency of multiple coagulation factors during bleeding. In past years, use of FFP has increased, in particular in patients on the Intensiv...

    Authors: Marcella CA Müller, Evert de Jonge, M Sesmu Arbous, Angelique ME Spoelstra -de Man, Atilla Karakus, Margreeth B Vroom and Nicole P Juffermans

    Citation: Trials 2011 12:266

    Content type: Study protocol

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  40. Poorly controlled hypertension (HTN) remains one of the most significant public health problems in the United States, in terms of morbidity, mortality, and economic burden. Despite compelling evidence supporti...

    Authors: Antoinette Schoenthaler, Leanne Luerassi, Jeanne A Teresi, Stephanie Silver, Jian Kong, Taiye Odedosu, Samantha Trilling, Anna Errico, Oshevire Uvwo, Kimberly Sebek, Adetutu Adekoya and Gbenga Ogedegbe

    Citation: Trials 2011 12:265

    Content type: Study protocol

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  41. Exercise programmes can be administered successfully as therapeutic agents to patients with a number of chronic diseases and help to improve physical functioning in older adults. Usually, such programmes targe...

    Authors: Timo Hinrichs, Anna Moschny, Michael Brach, Stefan Wilm, Renate Klaaßen-Mielke, Matthias Trampisch and Petra Platen

    Citation: Trials 2011 12:263

    Content type: Study protocol

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  42. The aim of this study was to evaluate the antiplaque effect of a new alcohol free essential oil mouthwash with respect to a control of an essential oil with alcohol mouthwash, using an in vivo plaque regrowth mod...

    Authors: Enrico Marchetti, Stefano Mummolo, Jonathan Di Mattia, Fabio Casalena, Salvatore Di Martino, Antonella Mattei and Giuseppe Marzo

    Citation: Trials 2011 12:262

    Content type: Research

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  43. High quality evidence indicates that aspirin is effective in reducing colorectal polyps; and numerous epidemiological studies point towards an ability to prevent colorectal cancer. However the role of Aspirin ...

    Authors: Raghib Ali, Han-Chong Toh and Whay-Kuang Chia

    Citation: Trials 2011 12:261

    Content type: Study protocol

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  44. Asthma is a prevalent and costly disease resulting in reduced quality of life for a large proportion of individuals. Effective patient self-management is critical for improving health outcomes. However, key as...

    Authors: Sara Ahmed, Susan J Bartlett, Pierre Ernst, Guy Paré, Maria Kanter, Robert Perreault, Roland Grad, Laurel Taylor and Robyn Tamblyn

    Citation: Trials 2011 12:260

    Content type: Study protocol

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  45. People with multiple sclerosis (MS) are at high risk of depression. We undertook a pilot trial of computerised cognitive behavioural therapy (CCBT) for the treatment of depression in people with MS to test the...

    Authors: Cindy L Cooper, Daniel Hind, Glenys D Parry, Claire L Isaac, Munyaradzi Dimairo, Alicia O'Cathain, Anita Rose, Jennifer V Freeman, Leonie Martin, Eva C Kaltenthaler, Anna Thake and Basil Sharrack

    Citation: Trials 2011 12:259

    Content type: Research

    Published on:

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