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  1. Following discharge home from the ICU, patients often suffer from reduced physical function, exercise capacity, health-related quality of life and social functioning. There is usually no support to address the...

    Authors: Brenda O'Neill, Kathryn McDowell, Judy Bradley, Bronagh Blackwood, Brian Mullan, Gavin Lavery, Ashley Agus, Sally Murphy, Evie Gardner and Daniel F McAuley
    Citation: Trials 2014 15:146
  2. Worldwide prevalence of generalized anxiety disorder (GAD) is considered high; in Europe lifetime prevalence has been estimated at 4.3 to 5.9%. High levels of anxiety disorders have been reported in university...

    Authors: Derek Richards, Ladislav Timulak, Gavin Doherty, John Sharry, Orla McLoughlin, Chuck Rashleigh, Amy Colla and Ciara Joyce
    Citation: Trials 2014 15:145
  3. Esophageal resection is associated with a high incidence of postoperative pneumonia. Respiratory complications account for almost half of the readmissions to the critical care unit. Postoperative complications...

    Authors: Karin Valkenet, Jaap CA Trappenburg, Rik Gosselink, Meindert N Sosef, Jerome Willms, Camiel Rosman, Heleen Pieters, Joris JG Scheepers, Saskia C de Heus, John V Reynolds, Emer Guinan, Jelle P Ruurda, Els HE Rodrigo, Philippe Nafteux, Marianne Fontaine, Ewout A Kouwenhoven…
    Citation: Trials 2014 15:144
  4. Hypertension is the leading global risk factor for mortality. Hypertension treatment and control rates are low worldwide, and delays in seeking care are associated with increased mortality. Thus, a critical co...

    Authors: Rajesh Vedanthan, Jemima H Kamano, Violet Naanyu, Allison K Delong, Martin C Were, Eric A Finkelstein, Diana Menya, Constantine O Akwanalo, Gerald S Bloomfield, Cynthia A Binanay, Eric J Velazquez, Joseph W Hogan, Carol R Horowitz, Thomas S Inui, Sylvester Kimaiyo and Valentin Fuster
    Citation: Trials 2014 15:143
  5. The New Forest Parenting Programme (NFPP) is a home-delivered, evidence-based parenting programme to target symptoms of attention-deficit/hyperactivity disorder (ADHD) in preschool children. It has been adapte...

    Authors: Donna C McCann, Margaret Thompson, David Daley, Joanne Barton, Cathy Laver-Bradbury, Judy Hutchings, David Coghill, Louise Stanton, Tom Maishman, Liz Dixon, Josh Caddy, Maria Chorozoglou, James Raftery and Edmund Sonuga-Barke
    Citation: Trials 2014 15:142
  6. Loneliness in older people is associated with poor health-related quality of life (HRQoL). We undertook a parallel-group randomised controlled trial to evaluate the effectiveness and cost-effectiveness of tele...

    Authors: Gail A Mountain, Daniel Hind, Rebecca Gossage-Worrall, Stephen J Walters, Rosie Duncan, Louise Newbould, Saleema Rex, Carys Jones, Ann Bowling, Mima Cattan, Angela Cairns, Cindy Cooper, Rhiannon Tudor Edwards and Elizabeth C Goyder
    Citation: Trials 2014 15:141
  7. The management of patients with angiographically intermediate coronary lesions is a major clinical issue. Fractional flow reserve provides validated functional insights while optical coherence tomography provi...

    Authors: Francesco Burzotta, Antonio Maria Leone, Giovanni Luigi De Maria, Giampaolo Niccoli, Valentina Coluccia, Giancarlo Pirozzolo, Silvia Saffioti, Cristina Aurigemma, Carlo Trani and Filippo Crea
    Citation: Trials 2014 15:140
  8. Continuous feedback on patient improvement and the therapeutic alliance may reduce the number of dropouts and increase patient outcome. There are, however, only three published randomized trials on the effect ...

    Authors: Annika Helgadóttir Davidsen, Stig Poulsen, Mette Waaddegaard, Jane Lindschou and Marianne Lau
    Citation: Trials 2014 15:138
  9. Laparoscopy training courses have been established in many centers worldwide to ensure adequate skill learning before performing operations on patients. Different training modalities and their combinations hav...

    Authors: Felix Nickel, Felix Jede, Andreas Minassian, Matthias Gondan, Jonathan D Hendrie, Tobias Gehrig, Georg R Linke, Martina Kadmon, Lars Fischer and Beat P Müller-Stich
    Citation: Trials 2014 15:137
  10. The Canola Oil Multicenter Intervention Trial (COMIT) was a randomized controlled crossover study designed to evaluate the effects of five diets that provided different oils and/or oil blends on cardiovascular...

    Authors: Vijitha K Senanayake, Shuaihua Pu, David A Jenkins, Benoît Lamarche, Penny M Kris-Etherton, Sheila G West, Jennifer A Fleming, Xiaoran Liu, Cindy E McCrea and Peter J Jones
    Citation: Trials 2014 15:136
  11. Coronary artery bypass grafting using the radial artery has, since the 1990s, gone through a revival. Observational studies have indicated better long-term patency when using radial arteries. Therefore, radial...

    Authors: Christian L Carranza, Martin Ballegaard, Mads U Werner, Philip Hasbak, Andreas Kjær, Klaus F Kofoed, Jane Lindschou, Janus Christian Jakobsen, Christian Gluud, Peter Skov Olsen and Daniel A Steinbrüchel
    Citation: Trials 2014 15:135
  12. Interventions promoting physical activity by General Practitioners (GPs) lack a strong evidence base. Recruiting participants to trials in primary care is challenging. We investigated the feasibility of (i) de...

    Authors: Fiona C Warren, Kate Stych, Margaret Thorogood, Deborah J Sharp, Marie Murphy, Katrina M Turner, Tim A Holt, Aidan Searle, Susan Bryant, Caroline Huxley, Rod S Taylor, John L Campbell and Melvyn Hillsdon
    Citation: Trials 2014 15:134
  13. Stroke is a leading cause of death worldwide. Infections after stroke occur in 30% of stroke patients and are strongly associated with unfavourable outcome. Preventive antibiotic therapy lowers infection rate ...

    Authors: Willeke F Westendorp, Jan-Dirk Vermeij, Nan van Geloven, Diederik WJ Dippel, Marcel GW Dijkgraaf, Tom van der Poll, Jan M Prins, Lodewijk Spanjaard, Frederique H Vermeij, Paul J Nederkoorn and Diederik van de Beek
    Citation: Trials 2014 15:133
  14. Chronic neck pain (CNP) is a common painful medical condition with a significant socioeconomic impact. In spite of widespread usage, the effectiveness and safety of combined treatments between conventional and...

    Authors: Byung-Kwan Seo, Jun-Hwan Lee, Pil-Kun Kim, Yong-Hyeon Baek, Dae-Jean Jo and Sanghun Lee
    Citation: Trials 2014 15:132
  15. Chronic shoulder pain (CSP) is the third most common type of musculoskeletal pain. It has a major impact on health-related quality of life. In Chinese medicine, CSP is considered one of the conditions most ame...

    Authors: Qing-Nan Fu, Guang-Xia Shi, Qian-Qian Li, Tian He, Bao-Zhen Liu, San-Feng Sun, Jun Wang, Cheng Tan, Bo-Feng Yang and Cun-Zhi Liu
    Citation: Trials 2014 15:130
  16. The physical and mental health of college-age youths tends to continuously decline around the world. It is therefore important to promote health during this period. As a traditional Chinese mind-body exercise,...

    Authors: Guohua Zheng, Xiulu Lan, Moyi Li, Kun Ling, Hui Lin, Lidian Chen, Jing Tao, Junzhe Li, Xin Zheng, Bai Chen and Qianying Fang
    Citation: Trials 2014 15:129
  17. Some level of monitoring is usually required during a clinical trial to protect the rights and safety of trial participants and to safeguard the quality and reliability of trial results. Although there is incr...

    Authors: Catrin Tudur Smith, Paula Williamson, Ashley Jones, Alan Smyth, Simon Langton Hewer and Carrol Gamble
    Citation: Trials 2014 15:127
  18. When a child participates in a clinical trial, informed consent has to be given by the parents. Parental motives for participation are complex, but the hope of getting a new and better treatment for the child ...

    Authors: Sandra Meinich Petersen, Vibeke Zoffmann, Jesper Kjærgaard, Lone Graff Steensballe and Gorm Greisen
    Citation: Trials 2014 15:126

    The Erratum to this article has been published in Trials 2015 16:93

  19. This randomized control trial assesses the effectiveness of motivational interviewing (MI) to encourage behavior change in new mothers relating to caries prevention when caring for their newborn American India...

    Authors: Terrence Batliner, Karen A Fehringer, Tamanna Tiwari, William G Henderson, Anne Wilson, Angela G Brega and Judith Albino
    Citation: Trials 2014 15:125
  20. Heart failure is a prevalent health problem associated with costly hospital readmissions. Transitional care programs have been shown to reduce readmissions but are costly to implement. Evidence regarding the e...

    Authors: Jeanne T Black, Patrick S Romano, Banafsheh Sadeghi, Andrew D Auerbach, Theodore G Ganiats, Sheldon Greenfield, Sherrie H Kaplan and Michael K Ong
    Citation: Trials 2014 15:124
  21. After stroke, pneumonia is a relevant medical complication that can be precipitated by aspiration of saliva, liquids, or solid food. Swallowing difficulty and aspiration occur in a significant proportion of st...

    Authors: Stefan Tino Kulnik, Gerrard Francis Rafferty, Surinder S Birring, John Moxham and Lalit Kalra
    Citation: Trials 2014 15:123
  22. Venous thromboembolism is common in patients with cancer and requires anticoagulation with low molecular weight heparin. Current data informs anticoagulation as far as six months, yet guidelines recommend anti...

    Authors: Joanna D Smith, Jessica Baillie, Trevor Baglin, Gareth O Griffiths, Angela Casbard, David Cohen, David A Fitzmaurice, Kerenza Hood, Peter Rose, Alexander T Cohen, Miriam Johnson, Anthony Maraveyas, John Bell, Harold Toone, Annmarie Nelson and Simon I Noble
    Citation: Trials 2014 15:122
  23. Radiofrequency ablation (RFA) is associated with an excellent outcome in the treatment of great saphenous vein (GSV) incompetence. The use of thermal energy as a treatment source requires the instillation of t...

    Authors: Ramon RJP van Eekeren, Doeke Boersma, Suzanne Holewijn, Anco Vahl, Jean Paul PM de Vries, Clark J Zeebregts and Michel MPJ Reijnen
    Citation: Trials 2014 15:121
  24. Fibromyalgia patients are often advised to engage in regular low- to moderate-intensity physical exercise. The need of fibromyalgia patients to walk has been stressed in previous research. Behavioral self-regu...

    Authors: María-Ángeles Pastor, Sofía López-Roig, Ana Lledó, Cecilia Peñacoba, Lilian Velasco, Inge Schweiger-Gallo, Margarita Cigarán, Carmen Écija, Ramón Limón and Yolanda Sanz
    Citation: Trials 2014 15:120
  25. Despite the increasing use of pre- and posthydration protocols and low-osmolar instead of high-osmolar iodine-containing contrast media, the incidence of contrast-induced nephropathy (CIN) is still significant...

    Authors: Thomas B Sterenborg, Theo P Menting, Yvonne de Waal, Rogier Donders, Kimberley E Wever, M Susan Lemson, Daan JA van der Vliet, Jack F Wetzels, Leo J SchultzeKool and Michiel C Warlé
    Citation: Trials 2014 15:119
  26. Despite growing interest in the importance of, and challenges associated with the involvement of patient and population (IPP) in the process of developing and adapting clinical practice guidelines (CPGs), ther...

    Authors: Marie-Eve Lamontagne, Kadija Perreault and Marie-Pierre Gagnon
    Citation: Trials 2014 15:118
  27. Erosive degenerative disc disease, also known as Modic type 1 changes, is usually characterized by low back pain with an inflammatory pain pattern, as seen in spondyloarthropathies. Intravenous pamidronate has...

    Authors: Stella Cecchetti, Bruno Pereira, Antoine Roche, Christophe Deschaumes, Dihya Abdi, Emmanuel Coudeyre, Jean-Jacques Dubost, Sylvain Mathieu, Sandrine Malochet-Guinamand, Anne Tournadre, Marion Couderc, Marielle Vayssade, Coline Daron and Martin Soubrier
    Citation: Trials 2014 15:117
  28. Type 2 diabetes, also known non-insulin-dependent diabetes, is the most prevalent type of the disease and involves defects in the secretion and action of insulin. The aim of the proposed study is to evaluate t...

    Authors: Cid André Fidelis de Paula Gomes, Ernesto Cesar Pinto Leal-Junior, Daniela Aparecida Biasotto-Gonzalez, Yasmin El-Hage, Fabiano Politti, Tabajara de Oliveira Gonzalez, Almir Vieira Dibai-Filho, Adriano Rodrigues de Oliveira, Marcelo Frigero, Fernanda Colella Antonialli, Adriane Aver Vanin and Paulo de Tarso Camillo de Carvalho
    Citation: Trials 2014 15:116
  29. Patients with chronic autoimmune thyroiditis have impaired health-related quality of life. The thyroid gland has a high selenium concentration, and specific selenoprotein enzyme families are crucial to immune ...

    Authors: Kristian Hillert Winther, Torquil Watt, Jakob Bue Bjørner, Per Cramon, Ulla Feldt-Rasmussen, Christian Gluud, Jeppe Gram, Mogens Groenvold, Laszlo Hegedüs, Nils Knudsen, Åse Krogh Rasmussen and Steen Joop Bonnema
    Citation: Trials 2014 15:115
  30. Computer-assisted surgery plays an increasingly important role in mandibular reconstruction, ensuring the best possible masticatory function and aesthetic outcome.

    Authors: Nassim Ayoub, Alireza Ghassemi, Majeed Rana, Marcus Gerressen, Dieter Riediger, Frank Hölzle and Ali Modabber
    Citation: Trials 2014 15:114
  31. Stroke is a major cause of death and disability in the world, and the prevalence of stroke tends to increase with age. Despite advances in acute care and secondary preventive strategies, primary prevention sho...

    Authors: Guohua Zheng, Bai Chen, Qianying Fang, Hongmei Yi, Qiu Lin, Lidian Chen, Jing Tao, Junzhe Li, Xin Zheng, Moyi Li and Xiulu Lan
    Citation: Trials 2014 15:113
  32. Panic disorder and agoraphobia are debilitating and frequently comorbid anxiety disorders. A large number of patients with these conditions are treated by general practitioners in primary care. Cognitive behav...

    Authors: Jochen Gensichen, Thomas S Hiller, Jörg Breitbart, Tobias Teismann, Christian Brettschneider, Ulrike Schumacher, Alexander Piwtorak, Hans-Helmut König, Heike Hoyer, Nico Schneider, Mercedes Schelle, Wolfgang Blank, Paul Thiel, Michel Wensing and Jürgen Margraf
    Citation: Trials 2014 15:112
  33. Isovolemic anemia (decrease in hemoglobin concentration with normal or even increased blood volume) after gastric cancer surgery may negatively influence short- and long-term outcomes. Therefore correction of ...

    Authors: Daniel Reim, Young-Woo Kim, Byung Ho Nam, Mi-Jung Kim, Jeong Hwan Yook, Young Kyu Park, Sung Hoon Roh, Wan Sik Yu and Jae Moon Bae
    Citation: Trials 2014 15:111
  34. During leisure activities young people are often exposed to excessive noise levels resulting in an increase of noise-induced symptoms such as hearing loss, tinnitus and hyperacusis. Noise-induced tinnitus is o...

    Authors: Annick Gilles, Berina Ihtijarevic, Kristien Wouters and Paul Van de Heyning
    Citation: Trials 2014 15:110
  35. Chronic obstructive pulmonary disease (COPD) remains a major health problem, strongly related to smoking. Despite the publication of practice guidelines on prevention and treatment, not all patients with the d...

    Authors: Maciek Godycki-Cwirko, Izabela Zakowska, Katarzyna Kosiek, Michel Wensing, Jaroslaw Krawczyk and Anna Kowalczyk
    Citation: Trials 2014 15:109
  36. Asthma is the most prevalent chronic disease to complicate pregnancies worldwide, affecting around 12% of pregnant women in Australia. Oxidative stress and inflammation manifest during pregnancy; however asthm...

    Authors: Jessica A Grieger, Lisa G Wood and Vicki L Clifton
    Citation: Trials 2014 15:108
  37. Despite major advances in transplant medicine, improvements in long-term kidney allograft survival have not been commensurate with those observed shortly after transplantation. The formation of donor-specific ...

    Authors: Farsad Eskandary, Gregor Bond, Elisabeth Schwaiger, Zeljko Kikic, Christine Winzer, Markus Wahrmann, Lena Marinova, Helmuth Haslacher, Heinz Regele, Rainer Oberbauer and Georg A Böhmig
    Citation: Trials 2014 15:107
  38. Femorotibial knee osteoarthritis is associated with muscle weakness in the lower limbs, particularly in the quadriceps, which results in disease progression. The interest of having muscular strengthening as pa...

    Authors: Anne-Gaëlle Jegu, Bruno Pereira, Nicolas Andant and Emmanuel Coudeyre
    Citation: Trials 2014 15:106
  39. Spondylolisthesis is the major cause of refractory low back pain. There are many studies of the surgical treatment of spondylolisthesis, but few of conservative treatments. There is also no optimal conservativ...

    Authors: Hyun-jong Lee, Jung-Chul Seo, Min-Ah Kwak, Sung-Hoon Park, Bo-Mi Min, Min-su Cho, ImHee Shin, Jin-yong Jung and Woon-seok Roh
    Citation: Trials 2014 15:105
  40. Low back pain affects approximately 80% of people at some stage in their lives. Exercise therapy is the most widely used nonsurgical intervention for low back pain in practice guidelines. Whole body vibration ...

    Authors: Xue-Qiang Wang, Yan-Lin Pi, Pei-Jie Chen, Bin-Lin Chen, Lei-Chao Liang, Xin Li, Xiao Wang and Juan Zhang
    Citation: Trials 2014 15:104
  41. In many therapeutic areas, individual patient markers have been identified that are associated with differential treatment response. These markers include both baseline characteristics, as well as short-term c...

    Authors: Ruud Boessen, Hiddo J Lambers Heerspink, Dick De Zeeuw, Diederick E Grobbee, Rolf HH Groenwold and Kit CB Roes
    Citation: Trials 2014 15:103
  42. Low back pain (LBP) is a prevalent condition and a socioeconomic problem in many countries. Due to its recurrent nature, the prevention of further episodes (secondary prevention), seems logical. Furthermore, w...

    Authors: Andreas Eklund, Iben Axén, Alice Kongsted, Malin Lohela-Karlsson, Charlotte Leboeuf-Yde and Irene Jensen
    Citation: Trials 2014 15:102
  43. The leading mental health causes of the global burden of disease are depression in women and alcohol use disorders in men. A major hurdle to the implementation of evidence-based psychological treatments in pri...

    Authors: Vikram Patel, Benedict Weobong, Abhijit Nadkarni, Helen A Weiss, Arpita Anand, Smita Naik, Bhargav Bhat, Jesina Pereira, Ricardo Araya, Sona Dimidjian, Steven D Hollon, Michael King, Jim McCambridge, David McDaid, Pratima Murthy, Richard Velleman…
    Citation: Trials 2014 15:101
  44. The apolipoprotein A5 gene (APOA5) -1131 T > C polymorphism is associated with mild hypertriglyceridemia in type 2 diabetic subjects, and interacts with dietary fat in the determination of triglyceride concentrat...

    Authors: Ryungwoo Kang, Minjoo Kim, Jey Sook Chae, Sang-Hyun Lee and Jong Ho Lee
    Citation: Trials 2014 15:100
  45. Mild hypoxia is common in stroke patients and may have significant adverse effects on the ischemic brain after stroke. The use of oxygen treatment is rapidly increasing in European stroke units but is not with...

    Authors: Christine Roffe, Tracy Nevatte, Peter Crome, Richard Gray, Julius Sim, Sarah Pountain, Linda Handy and Peter Handy
    Citation: Trials 2014 15:99
  46. Recruiting to randomized controlled trials is fraught with challenges; with less than one third recruiting to their original target. In preparation for a trial evaluating the effectiveness of a blood test to s...

    Authors: Roshan das Nair, Kate Skellington Orr, Kavita Vedhara and Denise Kendrick
    Citation: Trials 2014 15:98
  47. Colorectal cancer (CRC) is the second most prevalent type of cancer in Europe. A single flexible sigmoidoscopy (FS) screening at around the age of 60 years prevents about one-third of CRC cases. However, FS sc...

    Authors: Daniele Regge, Gabriella Iussich, Carlo Senore, Loredana Correale, Cesare Hassan, Alberto Bert, Stefania Montemezzi and Nereo Segnan
    Citation: Trials 2014 15:97

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