Skip to main content

Advertisement

Articles

Page 120 of 134

  1. There is now convincing evidence that in industrialized countries therapeutic hypothermia for perinatal asphyxial encephalopathy increases survival with normal neurological function. However, the greatest burd...

    Authors: Nicola J Robertson, Cornelia F Hagmann, Dominique Acolet, Elizabeth Allen, Natasha Nyombi, Diana Elbourne, Anthony Costello, Ian Jacobs, Margaret Nakakeeto and Frances Cowan

    Citation: Trials 2011 12:138

    Content type: Research

    Published on:

  2. The common randomized controlled trial design has distinct limitations when applied to Chinese medicine, because Chinese medicine identifies and treats 'Chinese medicine patterns' rather than diagnosed disease...

    Authors: Chi Zhang, Miao Jiang and Aiping Lu

    Citation: Trials 2011 12:137

    Content type: Study protocol

    Published on:

  3. Neonatal mortality remains high in rural Nepal. Previous work suggests that local women's groups can effect significant improvement through community mobilisation. The possibility of identification and managem...

    Authors: Bhim P Shrestha, Bishnu Bhandari, Dharma S Manandhar, David Osrin, Anthony Costello and Naomi Saville

    Citation: Trials 2011 12:136

    Content type: Study protocol

    Published on:

  4. People who present to hospital after intentionally harming themselves pose a common and important problem. Previous reviews of interventions have been inconclusive as existing trials have been under powered an...

    Authors: Simon Hatcher, Cynthia Sharon, Allan House, Sunny Collings, Varsha Parag and Nicola Collins

    Citation: Trials 2011 12:135

    Content type: Study protocol

    Published on:

  5. Claudication secondary to peripheral artery disease (PAD) is associated with substantial functional impairment. Phosphodiesterase (PDE) inhibitors have been shown to increase walking performance in these patie...

    Authors: Roger J Lewis, Jason T Connor, John R Teerlink, James R Murphy, Leslie T Cooper, William R Hiatt and Eric P Brass

    Citation: Trials 2011 12:134

    Content type: Research

    Published on:

  6. Glaucoma is the leading cause of irreversible blindness. Although primary open-angle glaucoma is more common, primary angle-closure glaucoma (PACG) is more likely to result in irreversible blindness. By 2020, ...

    Authors: Augusto Azuara-Blanco, Jennifer M Burr, Claire Cochran, Craig Ramsay, Luke Vale, Paul Foster, David Friedman, Zahidul Quayyum, Jimmy Lai, Winnie Nolan, Tin Aung, Paul Chew, Gladys McPherson, Alison McDonald and John Norrie

    Citation: Trials 2011 12:133

    Content type: Study protocol

    Published on:

  7. This protocol is for a study of a new program to improve outcomes in children suffering from chronic pain disorders, such as fibromyalgia, recurrent headache, or recurrent abdominal pain. Although teaching act...

    Authors: Laura B Allen, Jennie CI Tsao, Loran P Hayes and Lonnie K Zeltzer

    Citation: Trials 2011 12:132

    Content type: Study protocol

    Published on:

  8. Urinary incontinence following acute stroke is common, affecting between 40%-60% of people in hospital after a stroke. Despite the availability of clinical guidelines for urinary incontinence and urinary incon...

    Authors: Lois H Thomas, Caroline L Watkins, Beverley French, Christopher Sutton, Denise Forshaw, Francine Cheater, Brenda Roe, Michael J Leathley, Christopher Burton, Elaine McColl and Jo Booth

    Citation: Trials 2011 12:131

    Content type: Study protocol

    Published on:

  9. Breathlessness in advanced disease causes significant distress to patients and carers and presents management challenges to health care professionals. The Breathlessness Intervention Service (BIS) seeks to imp...

    Authors: Morag C Farquhar, A Toby Prevost, Paul McCrone, Irene J Higginson, Jennifer Gray, Barbara Brafman-Kennedy and Sara Booth

    Citation: Trials 2011 12:130

    Content type: Study protocol

    Published on:

  10. Pancreatic cancer is the fourth leading cause of cancer death in the United States. Surgery offers the only chance for cure. However, less than twenty percent of patients are considered operative candidates at...

    Authors: Jeremy L Davis, Prakash Pandalai, R Taylor Ripley, Russell C Langan, Seth M Steinberg, Melissa Walker, Mary Ann Toomey, Elliot Levy and Itzhak Avital

    Citation: Trials 2011 12:129

    Content type: Study protocol

    Published on:

  11. Birth attendance by trained health workers is low in rural Nepal. Local participation in improving health services and increased interaction between health systems and communities may stimulate demand for heal...

    Authors: Joanna Morrison, Kirti Man Tumbahangphe, Bharat Budhathoki, Rishi Neupane, Aman Sen, Kunta Dahal, Rita Thapa, Reema Manandhar, Dharma Manandhar, Anthony Costello and David Osrin

    Citation: Trials 2011 12:128

    Content type: Study protocol

    Published on:

  12. Cigarette smoking is the number one cause of preventable death among American Indian and Alaska Natives, AI/ANs. Two out of every five AI/AN will die from tobacco-related diseases if the current smoking rates ...

    Authors: Won S Choi, Babalola Faseru, Laura A Beebe, Allen K Greiner, Hung-Wen Yeh, Theresa I Shireman, Myrietta Talawyma, Lance Cully, Baljit Kaur and Christine M Daley

    Citation: Trials 2011 12:126

    Content type: Study protocol

    Published on:

  13. Interventions for preventing falls in older people often involve several components, multidisciplinary teams, and implementation in a variety of settings. We have developed a classification system (taxonomy) t...

    Authors: Sarah E Lamb, Clemens Becker, Lesley D Gillespie, Jessica L Smith, Susanne Finnegan, Rachel Potter and Klaus Pfeiffer

    Citation: Trials 2011 12:125

    Content type: Methodology

    Published on:

  14. Within the spectrum of spontaneous intracerebral haemorrhage there are some patients with large or space occupying haemorrhage who require surgery for neurological deterioration and others with small haematoma...

    Authors: A David Mendelow, Barbara A Gregson, Patrick M Mitchell, Gordon D Murray, Elise N Rowan and Anil R Gholkar

    Citation: Trials 2011 12:124

    Content type: Study protocol

    Published on:

  15. Patients with delirium and dementia admitted to general hospitals have poor outcomes, and their carers report poor experiences. We developed an acute geriatric medical ward into a specialist Medical and Mental...

    Authors: Rowan H Harwood, Sarah E Goldberg, Kathy H Whittamore, Catherine Russell, John RF Gladman, Rob G Jones, Davina Porock, Sarah A Lewis, Lucy E Bradshaw and Rachel A Elliot

    Citation: Trials 2011 12:123

    Content type: Study protocol

    Published on:

  16. Randomized controlled trials (RCTs) which are of poor quality tend to exaggerate the effect estimate and lead to wrong or misleading conclusions. The aim of this study is to assess the quality of randomization...

    Authors: Jia He, Liang Du, Guanjian Liu, Jin Fu, Xiangyu He, Jiayun Yu and Lili Shang

    Citation: Trials 2011 12:122

    Content type: Methodology

    Published on:

  17. As a major public health issue in China and worldwide, late-life depression is associated with physical limitations, greater functional impairment, increased utilization and cost of health care, and suicide. L...

    Authors: Shulin Chen, Yeates Conwell, Baihua Xu, Helen Chiu, Xin Tu and Yan Ma

    Citation: Trials 2011 12:121

    Content type: Study protocol

    Published on:

  18. Combination of erlotinib and bevacizumab is a promising regimen in advanced non-squamous non-small-cell lung cancer (NSCLC). We are conducting a single arm phase II trial which aims to evaluate the efficacy an...

    Authors: Shiro Tanaka, Yuichi Sakamori, Miyuki Niimi, Megumi Hazama, Young H Kim and Kazuhiro Yanagihara

    Citation: Trials 2011 12:120

    Content type: Study protocol

    Published on:

  19. Delirium is a state of confusion characterized by an acute and fluctuating decline in cognitive functioning. Delirium is common and deadly in older adults with dementia, and is often referred to as delirium su...

    Authors: Ann M Kolanowski, Donna M Fick, Mark S Litaker, Linda Clare, Doug Leslie and Malaz Boustani

    Citation: Trials 2011 12:119

    Content type: Study protocol

    Published on:

  20. This article is part of a series of papers examining ethical issues in cluster randomized trials (CRTs) in health research. In the introductory paper in this series, Weijer and colleagues set out six areas of ...

    Authors: Ariella Binik, Charles Weijer, Andrew D McRae, Jeremy M Grimshaw, Robert Boruch, Jamie C Brehaut, Allan Donner, Martin P Eccles, Raphael Saginur, Monica Taljaard and Merrick Zwarenstein

    Citation: Trials 2011 12:118

    Content type: Research

    Published on:

  21. Maori, the indigenous people of New Zealand, who present to hospital after intentionally harming themselves, do so at a higher rate than non-Maori. There have been no previous treatment trials in Maori who sel...

    Authors: Simon Hatcher, Nicole Coupe, Mason Durie, Hinemoa Elder, Rees Tapsell, Karen Wikiriwhi and Varsha Parag

    Citation: Trials 2011 12:117

    Content type: Study protocol

    Published on:

  22. After more than half a century of modern psychopharmacology, with billions of dollars spent on antidepressants annually world-wide, we lack good evidence to guide our everyday decisions in conducting antidepre...

    Authors: Toshi A Furukawa, Tatsuo Akechi, Shinji Shimodera, Mitsuhiko Yamada, Kazuhira Miki, Norio Watanabe, Masatoshi Inagaki and Naohiro Yonemoto

    Citation: Trials 2011 12:116

    Content type: Study protocol

    Published on:

  23. The purpose of this research is to develop and evaluate methods for conducting cluster randomised trials in a primary care database that contains electronic patient records for large numbers of family practice...

    Authors: Martin C Gulliford, Tjeerd van Staa, Lisa McDermott, Alex Dregan, Gerard McCann, Mark Ashworth, Judith Charlton, Andrew P Grieve, Paul Little, Michael V Moore and Lucy Yardley

    Citation: Trials 2011 12:115

    Content type: Study protocol

    Published on:

  24. Overweight and obesity are linked with Binge Eating Disorder (BED). Effective interventions to significantly reduce weight, maintain weight loss and manage associated pathologies like BED are tipically combine...

    Authors: Gianluca Castelnuovo, Gian Mauro Manzoni, Valentina Villa, Gian Luca Cesa, Giada Pietrabissa and Enrico Molinari

    Citation: Trials 2011 12:114

    Content type: Study protocol

    Published on:

  25. The Acute Respiratory Distress Syndrome (ARDS) is a common cause of respiratory failure in critically ill patients. Experimental studies suggest that treatment with beta agonists may be helpful in ARDS. The Be...

    Authors: Gavin D Perkins, Simon Gates, Sarah E Lamb, Chris McCabe, Duncan Young and Fang Gao

    Citation: Trials 2011 12:113

    Content type: Study protocol

    Published on:

  26. The UK Clinical Trial Regulations and Good Clinical Practice guidelines specify that the study sponsor must ensure clinical trial data are accurately reported, recorded and verified to ensure patient safety an...

    Authors: Elizabeth P Tolmie, Eleanor M Dinnett, Elizabeth S Ronald and Allan Gaw

    Citation: Trials 2011 12:112

    Content type: Research

    Published on:

  27. Post-operative pulmonary complications add to the morbidity and mortality of surgical patients, in particular after general anesthesia >2 hours for abdominal surgery. Whether a protective mechanical ventilatio...

    Authors: Sabrine NT Hemmes, Paolo Severgnini, Samir Jaber, Jaume Canet, Hermann Wrigge, Michael Hiesmayr, Edda M Tschernko, Markus W Hollmann, Jan M Binnekade, Göran Hedenstierna, Christian Putensen, Marcelo Gama de Abreu, Paolo Pelosi and Marcus J Schultz

    Citation: Trials 2011 12:111

    Content type: Study protocol

    Published on:

  28. The prevalence of childhood obesity has increased rapidly during the last three decades in the Netherlands. It is assumed that mainly environmental factors have contributed to this trend. Parental overweight a...

    Authors: Rimke C Vos, Jan M Wit, Hanno Pijl, Carolien C Kruyff and Euphemia CAM Houdijk

    Citation: Trials 2011 12:110

    Content type: Study protocol

    Published on:

  29. Trial research has predominantly focused on patient and staff understandings of trial concepts and/or motivations for taking part, rather than why treatment recommendations may or may not be followed during tr...

    Authors: Julia Lawton, Nicholas Jenkins, Julie L Darbyshire, Rury R Holman, Andrew J Farmer and Nina Hallowell

    Citation: Trials 2011 12:108

    Content type: Research

    Published on:

  30. Recent attention has focused on strategies to combat the forecast epidemic of type-2 diabetes (T2DM) and its major vascular sequelae. Metabolic syndrome (MetS) comprises a constellation of factors that increas...

    Authors: Alison J Dunkley, Melanie J Davies, Margaret A Stone, Nicholas A Taub, Jacqui Troughton, Thomas Yates and Kamlesh Khunti

    Citation: Trials 2011 12:107

    Content type: Research

    Published on:

  31. Non-inferiority trials test whether a new product is not unacceptably worse than a product already in use. This paper introduces concepts related to non-inferiority, and discusses the regulatory views of both ...

    Authors: Jennifer Schumi and Janet T Wittes

    Citation: Trials 2011 12:106

    Content type: Review

    Published on:

  32. Depression occurs in up to 50% of patients after stroke and limits rehabilitation and recovery. Mood disorders are also highly prevalent in carers; their mental health intertwined with the physical and mental ...

    Authors: Richard J Gray, Phyo K Myint, Frances Elender, Garry Barton, Michael Pfeil, Gill Price, Niki Wyatt, Garth Ravenhill, Ester Thomas, Jenny Jagger, Amelia Hursey, Kelly Waterfield and Sheila Hardy

    Citation: Trials 2011 12:105

    Content type: Study protocol

    Published on:

  33. Prospective meta-analysis (PMA) is a collaborative research design in which individual sites perform randomized controlled trials (RCTs) and pool the data for meta-analysis. Members of the PMA collaboration ag...

    Authors: David K Turok, Eve Espey, Alison B Edelman, Pamela S Lotke, Eva H Lathrop, Stephanie B Teal, Janet C Jacobson, Sara E Simonsen and Kenneth F Schulz

    Citation: Trials 2011 12:104

    Content type: Methodology

    Published on:

  34. Cancer diseases and their therapies have negative effects on the quality of life. The aim of this study is to assess the effectiveness of case management in a sample of oncological outpatients with the intent ...

    Authors: Irene Bachmann-Mettler, Claudia Steurer-Stey, Oliver Senn, Mathyas Wang, Katarina Bardheci and Thomas Rosemann

    Citation: Trials 2011 12:103

    Content type: Study protocol

    Published on:

  35. We present the design, methods and population characteristics of a large community trial that assessed the efficacy of a weekly supplement containing vitamin A or beta-carotene, at recommended dietary levels, ...

    Authors: Alain B Labrique, Parul Christian, Rolf DW Klemm, Mahbubur Rashid, Abu Ahmed Shamim, Allan Massie, Kerry Schulze, Andre Hackman and Keith P West Jr

    Citation: Trials 2011 12:102

    Content type: Methodology

    Published on:

  36. We aimed to make individual patient data from the International Stroke Trial (IST), one of the largest randomised trials ever conducted in acute stroke, available for public use, to facilitate the planning of ...

    Authors: Peter AG Sandercock, Maciej Niewada and Anna Członkowska

    Citation: Trials 2011 12:101

    Content type: Research

    Published on:

    The Erratum to this article has been published in Trials 2012 13:24

  37. The cluster randomized trial (CRT) is used increasingly in knowledge translation research, quality improvement research, community based intervention studies, public health research, and research in developing...

    Authors: Charles Weijer, Jeremy M Grimshaw, Monica Taljaard, Ariella Binik, Robert Boruch, Jamie C Brehaut, Allan Donner, Martin P Eccles, Antonio Gallo, Andrew D McRae, Raphael Saginur and Merrick Zwarenstein

    Citation: Trials 2011 12:100

    Content type: Research

    Published on:

  38. Oropharyngeal candidasis is a common opportunistic infection seen in immunocompromised patients. Fluconazole has a broad spectrum antifungal activity including a wide variety of candida species. Aim of the presen...

    Authors: Harish M Nairy, Narayana R Charyulu, Veena A Shetty and Prabhu Prabhakara

    Citation: Trials 2011 12:99

    Content type: Research

    Published on:

  39. The CONSORT Statement was developed to help authors improve the quality of reporting randomized trials. To augment the statement we published the CONSORT explanation and elaboration paper which included at lea...

    Authors: David Moher, Sally Hopewell, Kenneth F Schulz and Douglas G Altman

    Citation: Trials 2011 12:98

    Content type: Editorial

    Published on:

  40. Targeted analgesic dietary interventions are a promising strategy for alleviating pain and improving quality of life in patients with persistent pain syndromes, such as chronic daily headache (CDH). High intak...

    Authors: Christopher E Ramsden, J Douglas Mann, Keturah R Faurot, Chanee Lynch, Syed Taha Imam, Beth A MacIntosh, Joseph R Hibbeln, James Loewke, Sunyata Smith, Rebecca Coble, Chirayath Suchindran and Susan A Gaylord

    Citation: Trials 2011 12:97

    Content type: Study protocol

    Published on:

  41. Several studies have showed that people with intellectual disabilities (ID) have suitable skills to undergo cognitive behavioural therapy (CBT). Case studies have reported successful use of cognitive behaviour...

    Authors: Angela Hassiotis, Marc Serfaty, Kiran Azam, Andre Strydom, Sue Martin, Charles Parkes, Robert Blizard and Michael King

    Citation: Trials 2011 12:95

    Content type: Study protocol

    Published on:

  42. Acute lower respiratory infections are the commonest cause of morbidity and potentially preventable mortality in Indigenous infants. Infancy is also a critical time for post-natal lung growth and development. ...

    Authors: Anne B Chang, Keith Grimwood, Andrew V White, Carolyn Maclennan, Theo P Sloots, Alan Sive, Gabrielle B McCallum, Ian M Mackay and Peter S Morris

    Citation: Trials 2011 12:94

    Content type: Study protocol

    Published on:

  43. The standard care in patients with a painful osteoporotic vertebral compression fracture (VCF) is conservative therapy. Percutaneous vertebroplasty (PV), a minimally invasive technique, is a new treatment opti...

    Authors: Cristina Firanescu, Paul NM Lohle, Jolanda de Vries, Caroline A Klazen, Job R Juttmann, William Clark and Willem Jan van Rooij

    Citation: Trials 2011 12:93

    Content type: Study protocol

    Published on:

  44. The effects of variations in exercise training on Left ventricular (LV) remodeling in patients shortly after Myocardial Infarction (MI) are important but poorly understood.

    Authors: Mark Haykowsky, Jessica Scott, Ben Esch, Don Schopflocher, Jonathan Myers, Ian Paterson, Darren Warburton, Lee Jones and Alexander M Clark

    Citation: Trials 2011 12:92

    Content type: Research

    Published on:

  45. Randomised controlled clinical (drug) trials supply high quality evidence for therapeutic strategies in primary care. Until now, experience with drug trials in German general practice has been sparse. In 2007/...

    Authors: Ildikó Gágyor, Jutta Bleidorn, Karl Wegscheider, Eva Hummers-Pradier and Michael M Kochen

    Citation: Trials 2011 12:91

    Content type: Research

    Published on:

  46. Due to improvements in cancer survival the number of people of working age living with cancer across Europe is likely to increase. UK governments have made commitments to reduce the number of working days lost...

    Authors: Richard G Kyle, Bill Culbard, Josie Evans, Nicola M Gray, Dolapo Ayansina and Gill Hubbard

    Citation: Trials 2011 12:89

    Content type: Study protocol

    Published on:

Annual Journal Metrics

Advertisement