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  1. Content type: Study protocol

    Total knee arthroplasty (TKA) is an optimal option for patients with middle-to-end-stage knee osteoarthritis. However, the management of postoperative acute pain remains inefficient. Transcutaneous electrical ...

    Authors: Yulin Li, Lixi Chu, Xiangming Li, Weitao Zhai, Yinghui Ma, Yong He, Yuelin Xu, Sheng Ding, Huali Gao, Jing Zhang, Bowen Ye, Jingchao Wang, Jie Yao, Chonggui Wu and Lianbo Xiao

    Citation: Trials 2019 20:306

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  2. Content type: Study protocol

    Obesity is associated with a chronic systemic inflammatory process. Volatile or intravenous anesthetic agents may modulate immune function, and may do so differentially in obesity. However, no study has evalua...

    Authors: Giselle Carvalho de Sousa, Fernanda Ferreira Cruz, Luciana Boavista Heil, Carlos José Saboya Sobrinho, Felipe Saddy, Frederico Paranhos Knibel, Joana Barreto Pereira, Marcus J. Schultz, Paolo Pelosi, Marcelo Gama de Abreu, Pedro Leme Silva and Patricia Rieken Macedo Rocco

    Citation: Trials 2019 20:300

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  3. Content type: Study protocol

    Three-dimensional (3D) stereoscopic vision is crucial to perform any kind of manual task. The reduction from real life 3D to virtual two-dimensional (2D) sight is a major challenge in minimally invasive surger...

    Authors: Roger Wahba, Rabi Raj Datta, Andrea Hedergott, Jana Bußhoff, Thomas Bruns, Robert Kleinert, Georg Dieplinger, Hans Fuchs, Caroline Giezelt, Desdemona Möller, Martin Hellmich, Christiane J. Bruns and Dirk L. Stippel

    Citation: Trials 2019 20:299

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  4. Content type: Study protocol

    Cardiovascular rehabilitation is one of the treatment options for post-stroke individuals in order to improve functional independence in activities of daily life and reduce energy expenditure. The aim of this ...

    Authors: Josiela Cristina da Silva Rodrigues, Gustavo José Luvizutto, Rafael Dalle Molle da Costa, Robson Aparecido Prudente, Taís Regina da Silva, Juli Thomaz de Souza, Caroline Ferreira da Silva Mazeto Pupo da Silveira, Daniele Andreza Antonelli Rossi, Fernanda Cristina Winckler, Gabriel Pinheiro Modolo, Tainá Fabri Carneiro Valadão, Letícia Cláudia de Oliveira Antunes, Luis Cuadrado Martin, Rodrigo Bazan and Silméia Garcia Zanati Bazan

    Citation: Trials 2019 20:298

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  5. Content type: Research

    The recruitment of participants into community-based randomized controlled trials studying childhood obesity is often challenging, especially from low-income racial/ethnical minorities and when long-term parti...

    Authors: Zhaohui Cui, Kimberly P. Truesdale, Thomas N. Robinson, Victoria Pemberton, Simone A. French, Juan Escarfuller, Terri L. Casey, Anne M. Hotop, Donna Matheson, Charlotte A. Pratt, Lynn J. Lotas, Eli Po’e, Sharon Andrisin and Dianne S. Ward

    Citation: Trials 2019 20:296

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  6. Content type: Study protocol

    Arterial stiffness is closely related to the process of atherosclerosis, an independent cardiovascular risk factor, and predictive of future cardiovascular events and mortality. Recently, we showed that magnes...

    Authors: Joëlle C. Schutten, Peter J. Joris, Ronald P. Mensink, Richard M. Danel, Frans Goorman, M. Rebecca Heiner-Fokkema, Rinse K. Weersma, Charlotte A. Keyzer, Martin H. de Borst and Stephan J. L. Bakker

    Citation: Trials 2019 20:295

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  7. Content type: Methodology

    In cluster-randomized controlled trials (C-RCTs), covariate-constrained randomization (CCR) methods efficiently control imbalance in multiple baseline cluster-level variables, but the choice of imbalance metri...

    Authors: Jody D. Ciolino, Alicia Diebold, Jessica K. Jensen, Gerald W. Rouleau, Kimberly K. Koloms and Darius Tandon

    Citation: Trials 2019 20:293

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  8. Content type: Study protocol

    An inappropriate anastomosis method during laparoscopic anterior rectal resection can increase the risk of anastomotic complications and affect surgical, economic, and oncological outcomes. The aim of this stu...

    Authors: Xiaolan You, Jian Wu, Yuanjie Wang, Qinghong Liu, Dehu Chen, Xiaojun Zhao, Yan Zhou, Xiaoqing Wu and Daorong Wang

    Citation: Trials 2019 20:292

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  9. Content type: Study protocol

    The number of women of childbearing age with chronic diseases is rising. Evidence has shown that obstetric complications and poor psychological well-being are more prevalent among this group, in addition to th...

    Authors: Mie Gaarskjaer de Wolff, Marianne Johansen, Anne S. Ersbøll, Susanne Rosthøj, Anne Brunsgaard, Julie Midtgaard, Ann Tabor and Hanne Kristine Hegaard

    Citation: Trials 2019 20:291

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  10. Content type: Study protocol

    Contrast-induced acute kidney injury (CI-AKI) contributes toward unfavorable clinical outcomes. Oral hydration with water is inexpensive and it may be effective in the prevention of CI-AKI, but its efficacy am...

    Authors: Feier Song, Guoli Sun, Jin Liu, Ji-yan Chen, Yibo He, Liwei Liu and Yong Liu

    Citation: Trials 2019 20:290

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  11. Content type: Research

    While a growing body of research has explored why people take part in clinical trials, this research has not considered how people’s understandings, motivations and agendas might influence their conduct during...

    Authors: Julia Lawton, Maxine Blackburn, Jenna P. Breckenridge, Nina Hallowell, Conor Farrington and David Rankin

    Citation: Trials 2019 20:289

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  12. Content type: Review

    There is an increasing number of interventions aimed at reducing the incidence and improving the identification and management of intimate partner violence (IPV), which are being tested in randomized clinical ...

    Authors: Kim Madden, Kerry Tai, Patricia Schneider, Nathan Evaniew, Michelle A. Ghert and Mohit Bhandari

    Citation: Trials 2019 20:288

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  13. Content type: Study protocol

    Undernutrition causes around 3.1 million child deaths annually, around 45% of all child deaths. India has one of the highest proportions of maternal and child undernutrition globally. To accelerate reductions ...

    Authors: Hassan Haghparast-Bidgoli, Jolene Skordis, Helen Harris-Fry, Sneha Krishnan, Meghan O’Hearn, Abhinav Kumar, Ronali Pradhan, Naba Kishore Mishra, Avinash Upadhyay, Shibananth Pradhan, Amit Kumar Ojha, Sarah Cunningham, Shibanand Rath, Tom Palmer, Peggy Koniz-Booher and Suneetha Kadiyala

    Citation: Trials 2019 20:287

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  14. Content type: Study protocol

    Sickle cell disease (SCD) is an inherited hematological disorder where the shape of red blood cells is altered, resulting in the destruction of red blood cells, anemia, and other complications. SCD is prevalen...

    Authors: Mohammed S. Alshahrani, Laila Perlas Asonto, Mohamed M. El Tahan, Amal H. Al Sulaibikh, Sukayna Z. Al Faraj, Abdullah A. Al Mulhim, Murad F. Al Abbad, Samar A. Al Nahhash, Moath N. Aldarweesh, Alaa M. Mahmoud, Nisreen Almaghraby, Mohammed A. Al Jumaan, Thamir O. Al Junaid, Faisal M. Al Hawaj, Samar AlKenany, Omaima F. ElSayed…

    Citation: Trials 2019 20:286

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  15. Content type: Research

    Poor recruitment is the most common reason for premature discontinuation of randomised controlled trials (RCTs). An RCT of medication versus psychological therapy for generalised anxiety disorder (GAD) was dis...

    Authors: Anastasia K. Kalpakidou, John Cape, Tarun J. Limbachya, Irwin Nazareth and Marta Buszewicz

    Citation: Trials 2019 20:284

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  16. Content type: Study protocol

    Acupuncture is effective in functional constipation (FC) treatment, but the central mechanism has not been well investigated. This trial will combine functional magnetic resonance imaging (fMRI) and positron e...

    Authors: Tao Yin, Zhaoxuan He, Peihong Ma, Likai Hou, Li Chen, Kunnan Xie, Zilei Tian, Fumin Wang, Jing Xiong, Yi Yang, Ruirui Sun and Fang Zeng

    Citation: Trials 2019 20:283

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  17. Content type: Study protocol

    Leisure activities can be both enjoyable and cognitively stimulating, and participation in such activities has been associated with reduced age-related cognitive decline. Thus, integrating stimulating leisure ...

    Authors: S. Belleville, A. Moussard, A. I. Ansaldo, P. Belchior, L. Bherer, N. Bier, V. D. Bohbot, M.-A. Bruneau, L. L. Cuddy, B. Gilbert, R. Jokel, K. Mahalingam, K. McGilton, K. J. Murphy, G. Naglie, E. Rochon…

    Citation: Trials 2019 20:282

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  18. Content type: Study protocol

    Septic shock is a major public health problem that is associated with up to 50% mortality. Unfavorable outcomes are mainly attributed to multiple organ failure (MOF) resulting from an uncontrolled inflammatory...

    Authors: Martin Cour, Marielle Buisson, Kada Klouche, Radhia Bouzgarrou, Carole Schwebel, Jean-Pierre Quenot, Fabrice Zeni, Pascal Beuret, Michel Ovize and Laurent Argaud

    Citation: Trials 2019 20:281

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  19. Content type: Study protocol

    Smoking in pregnancy is a major international public health problem. Self-help support (SHS) increases the likelihood of women stopping smoking in pregnancy and delivering this kind of support by text message ...

    Authors: Rachel Whitemore, Jo Leonardi-Bee, Felix Naughton, Stephen Sutton, Sue Cooper, Steve Parrott, Catherine Hewitt, Miranda Clark, Michael Ussher, Matthew Jones, David Torgerson and Tim Coleman

    Citation: Trials 2019 20:280

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  20. Content type: Study protocol

    Very preterm infants (< 32 weeks gestation) have a relatively high nutrient requirement for growth and development. The composition of human milk is often inadequate to ensure optimal growth so it is common to...

    Authors: Agnethe M. Ahnfeldt, Nana Hyldig, Yanqi Li, Susanne Soendergaard Kappel, Lise Aunsholdt, Per T. Sangild and Gitte Zachariassen

    Citation: Trials 2019 20:279

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  21. Content type: Study protocol

    The possible effect of transcranial direct current stimulation (tDCS) in improving cognitive function is clear from studies involving pre-dementia stage mild cognitive impairment (MCI). However, the applicatio...

    Authors: Jaesub Park, Yoonkyung Oh, Kyungmi Chung, Kwang Joon Kim, Chang Oh Kim and Jin Young Park

    Citation: Trials 2019 20:278

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  22. Content type: Study protocol

    The recommended psychological treatment of choice for obsessive-compulsive disorder (OCD) is exposure with response prevention (ERP). However, recovery rates are relatively modest, so better treatments are nee...

    Authors: Kim Melchior, Ingmar Franken, Mathijs Deen and Colin van der Heiden

    Citation: Trials 2019 20:277

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  23. Content type: Study protocol

    Quadratus lumborum block (QLB) is increasingly gaining popularity as a novel abdominal truncal block in abdominal surgery; however, the mechanism of QLB is not yet thoroughly illustrated. The focus of our stud...

    Authors: Qing Yuan, Xulei Cui, Yuda Fei, Zhonghuang Xu and Yuguang Huang

    Citation: Trials 2019 20:276

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  24. Content type: Study protocol

    Inappropriate staff behaviour during surgical procedures may disrupt the surgical performance and compromise patient safety. We developed an innovative monitoring and feedback system combined with an adaptive ...

    Authors: Gabriel Birgand, Thomas Haudebourg, Leslie Grammatico-Guillon, Léa Ferrand, Leila Moret, François Gouin, Nicolas Mauduit, Christophe Leux, Yannick Le Manach, Didier Lepelletier, Elsa Tavernier, Jean-Christophe Lucet and Bruno Giraudeau

    Citation: Trials 2019 20:275

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  25. Content type: Correction

    After publication of the original article [1], the authors have notified us that their originally submitted Table 1 was mistakenly replaced with Fig. 3 during editing. The original article has been corrected.

    Authors: Mike Ralf Langenbach and Dörthe Seidel

    Citation: Trials 2019 20:274

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    The original article was published in Trials 2019 20:188

  26. Content type: Study protocol

    Treatment non-adherence is a serious challenge to effective tuberculosis (TB) control in Tibet. In this study we will pilot and evaluate the effectiveness of using new electronic monitors (e-monitors) and a sm...

    Authors: Xiaolin Wei, Joseph Paul Hicks, Pande Pasang, Zhitong Zhang, Victoria Haldane, Xiaoqiu Liu, Tingting Yin, Lixia Wang, Dachun Shi, Shiliang Ge, John Walley, Ross Upshur and Jun Hu

    Citation: Trials 2019 20:273

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  27. Content type: Study protocol

    Evidence is limited on the effectiveness of mobile health programs which provide stage-based health information messages to pregnant and postpartum women. Kilkari is an outbound service that delivers weekly, s...

    Authors: Amnesty LeFevre, Smisha Agarwal, Sara Chamberlain, Kerry Scott, Anna Godfrey, Rakesh Chandra, Aditya Singh, Neha Shah, Diva Dhar, Alain Labrique, Aarushi Bhatnagar and Diwakar Mohan

    Citation: Trials 2019 20:272

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  28. Content type: Study protocol

    High rates of preterm births remain a UK public health concern. Preterm birth is a major determinant of adverse infant and longer-term outcomes, including survival, quality of life, psychosocial effects on the...

    Authors: C. Fernandez Turienzo, D. Bick, M. Bollard, L. Brigante, A. Briley, K. Coxon, P. Cross, A. Healey, M. Mehta, A. Melaugh, J. Moulla, P. T. Seed, A. H. Shennan, C. Singh, R. M. Tribe and J. Sandall

    Citation: Trials 2019 20:271

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  29. Content type: Study protocol

    Marked ethnic disparities on cervical cancer screening have been observed among South Asian women. Multiple barriers, such as language difficulties, poor access to screening services, values, and beliefs, were...

    Authors: Cho Lee Wong, Winnie Kwok Wei So, Dorothy Ngo Sheung Chan, Kai Chow Choi and Tika Rana

    Citation: Trials 2019 20:270

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  30. Content type: Study protocol

    Mosquito-borne viruses are imposing an ever increasing health burden worldwide. In addition to the recent Zika and chikungunya virus epidemics, dengue viruses have become the fastest growing problem with a 40-...

    Authors: Ferdinand Salazar, Jason Angeles, Ava Kristy Sy, Marianette T. Inobaya, Ariza Aguila, Tom Toner, Michael J. Bangs, Edward Thomsen and Richard E. Paul

    Citation: Trials 2019 20:269

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  31. Content type: Study protocol

    Children requiring hospitalization for psychiatric care have serious disorders, high use of psychotropic medication, and frequent readmissions. The development and implementation of therapies focused on incorp...

    Authors: Fanny Leyton, Marcia Olhaberry, Rubén Alvarado, Graciela Rojas, Luis Alberto Dueñas, George Downing and Howard Steele

    Citation: Trials 2019 20:268

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  32. Content type: Correction

    After publication of the original article [1], the authors have notified us that there are changes to the primary outcome of the study, instrument, subject’s inclusion criteria, the funding and acknowledgement...

    Authors: Chuo Yew Ting, Shahren Ahmad Zaidi Adruce, Mohamed Azmi Hassali, Hiram Ting, Chien Joo Lim, Rachel Sing-Kiat Ting, Abu Hassan Alshaari Abd Jabar, Nor Anizah Osman, Izzul Syazwan Shuib, Shing Chyi Loo, Sui Theng Sim and Su Ee Lim

    Citation: Trials 2019 20:267

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    The original article was published in Trials 2018 19:310

  33. Content type: Study protocol

    Randomised controlled trials (RCTs) are frequently unable to recruit sufficient numbers of participants. This affects the trial’s ability to answer the proposed research question, wastes resources and can be u...

    Authors: Keith R. Moffat, Paul Cannon, Wen Shi and Frank Sullivan

    Citation: Trials 2019 20:266

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  34. Content type: Study protocol

    Home blood pressure (BP) and unattended automated BP (uAOBP) monitoring have been recommended by guidelines for the care of hypertensive subjects. However, BP measurements in the peripheral arteries cannot ser...

    Authors: Hao-Min Cheng, Shih-Hsien Sung, Chen-Huan Chen, Wen-Chung Yu, Shu-Mei Yang, Chao-Yu Guo, Shao-Yuan Chuang and Chern-En Chiang

    Citation: Trials 2019 20:265

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  35. Content type: Study protocol

    Multiple sclerosis (MS) is an inflammatory disease of the central nervous system with a degenerative component, leading to irreversible disability. Mesenchymal stem cells (MSC) have been shown to prevent infla...

    Authors: Antonio Uccelli, Alice Laroni, Lou Brundin, Michel Clanet, Oscar Fernandez, Seyed Massood Nabavi, Paolo A. Muraro, Roberto S. Oliveri, Ernst W. Radue, Johann Sellner, Per Soelberg Sorensen, Maria Pia Sormani, Jens Thomas Wuerfel, Mario A. Battaglia and Mark S. Freedman

    Citation: Trials 2019 20:263

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  36. Content type: Study protocol

    Insomnia is a prevalent sleep disorder associated with significant economic and personal burdens. Cognitive behavioural therapy for insomnia (CBTI) is considered the gold standard intervention for insomnia and...

    Authors: Alix Mellor, Kellie Hamill, Melissa M. Jenkins, Donald H. Baucom, Peter J. Norton and Sean P. A. Drummond

    Citation: Trials 2019 20:262

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  37. Content type: Study protocol

    Data from a feasibility study suggest that the use of an inelastic, short-stretch compression bandage following total knee arthroplasty is a safe technique that may improve patient-reported health outcomes, an...

    Authors: Liz Cook, Matthew J. Northgraves, Caroline Fairhurst, Sarah Ronaldson, David J. Torgerson, Jonathan Kent and Mike Reed

    Citation: Trials 2019 20:261

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  38. Content type: Study protocol

    With the increasing amount of geriatric surgery, it has become a great challenge for anesthesiologists to reduce the incidence of postoperative pulmonary complications (PPCs). The two most popular airway manag...

    Authors: Ling Zhu, Xiao Shi, Suqing Yin, Jiemin Yin, Ziyu Zhu, Xiong Gao, Yingfu Jiao, Weifeng Yu and Liqun Yang

    Citation: Trials 2019 20:260

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  39. Content type: Correction

    After publication of the original article [1], the authors have notified us that two of the collaborator first and last names have been inverted in the “PROTHOR Investigators” table.

    Authors: T. Kiss, J. Wittenstein, C. Becker, K. Birr, G. Cinnella, E. Cohen, M. R. El Tahan, L. F. Falcão, C. Gregoretti, M. Granell, T. Hachenberg, M. W. Hollmann, R. Jankovic, W. Karzai, J. Krassler, T. Loop…

    Citation: Trials 2019 20:259

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    The original article was published in Trials 2019 20:213

  40. Content type: Study protocol

    Inspiratory muscle training (IMT) has brought great benefits in terms of improving physical performance in healthy individuals. However, there is no consensus regarding the best training load, as in most cases...

    Authors: Patricia Rehder-Santos, Vinicius Minatel, Juliana Cristina Milan-Mattos, Étore De Favari Signini, Raphael Martins de Abreu, Carla Cristina Dato and Aparecida Maria Catai

    Citation: Trials 2019 20:258

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  41. Content type: Study protocol

    Migraine is one of the most common neurological disorders in clinical practice and is a substantial cause of disability worldwide. Current approaches to therapy are primarily based on medication but are often ...

    Authors: Alice Pressman, Heather Law, Robert Stahl, Alex Scott, Alice Jacobson, Lisa Dean, Sylvia Sudat, Angelica Obillo and Andrew Avins

    Citation: Trials 2019 20:257

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  42. Content type: Methodology

    Low back pain (LBP) is a public health concern because it is highly prevalent and the leading cause of disability worldwide. Psychologically informed physical therapy (PIPT) is a secondary prevention approach ...

    Authors: Jason M. Beneciuk, Steven Z. George, Carol M. Greco, Michael J. Schneider, Stephen T. Wegener, Robert B. Saper and Anthony Delitto

    Citation: Trials 2019 20:256

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  43. Content type: Study protocol

    Hypotension is associated with serious complications, including myocardial infarction, acute kidney injury, and mortality. Consequently, predicting and preventing hypotension may improve outcomes. We will ther...

    Authors: Kamal Maheshwari, Tetsuya Shimada, Jonathan Fang, Ilker Ince, Edward J. Mascha, Alparslan Turan, Andrea Kurz and Daniel I. Sessler

    Citation: Trials 2019 20:255

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  44. Content type: Study protocol

    There is no consensus on the ventilation management during cardiopulmonary bypass (CPB), and the anesthesiologists or the surgeons usually ventilate the lungs with different ventilation strategies or keep them...

    Authors: Meng-Qiu Zhang, Yu-Qi Liao, Hong Yu, Xue-Fei Li, Liang Feng, Xiao-Yun Yang and Hai Yu

    Citation: Trials 2019 20:254

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  45. Content type: Study protocol

    Children in many low- and middle-income countries (LMICs) are at high risk for exposure to violence and later violent behaviour. The World Health Organization has declared an urgent need for the evaluation and...

    Authors: Joseph Murray, Iná S. Santos, Andréa D. Bertoldi, Lynne Murray, Adriane Arteche, Luciana Tovo-Rodrigues, Suélen Cruz, Luciana Anselmi, Rafaela Martins, Elisa Altafim, Tâmara Biolo Soares, Maria Gabriela Andriotti, Andrea Gonzalez, Isabel Oliveira, Mariângela Freitas da Silveira and Peter Cooper

    Citation: Trials 2019 20:253

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  46. Content type: Study protocol

    Treadmill training has been widely used for gait recovery after stroke. Gait re-establishment is one of the main objectives of rehabilitation programs after stroke, aiming to acquire more functional patterns a...

    Authors: Raiff Simplício da Silva, Stephano Tomaz da Silva, Jesimiel Missias de Souza, Marianna Celeste Cordeiro de Figueiredo, Thaís Almeida Silveira Mendes, Maria Clara de Sena Nunes, Samara Katiane Rolim de Oliveira, Daiane Carla Rodrigues Cardoso, Raiza Gabriella da Câmara Silva, Débora Carvalho de Oliveira and Tatiana Souza Ribeiro

    Citation: Trials 2019 20:252

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  47. Content type: Study protocol

    Lentils are generally considered to be a nutrient-dense food, and a good source of iron (Fe). This study aims to establish novel evidence of the effectiveness of the consumption of Fe-fortified lentils in impr...

    Authors: Fakir Md Yunus, Chowdhury Jalal, Kaosar Afsana, Rajib Podder, Albert Vandenberg and Diane M. DellaValle

    Citation: Trials 2019 20:251

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  48. Content type: Study protocol

    Staphylococcus aureus bacteremia (SAB) is frequently encountered in the hospital setting, and current guidelines recommend at least 14 days of antibiotic treatment for SAB in order to minimize risks of secondary ...

    Authors: Louise Thorlacius-Ussing, Christian Østergaard Andersen, Niels Frimodt-Møller, Inge Jenny Dahl Knudsen, Jens Lundgren and Thomas Lars Benfield

    Citation: Trials 2019 20:250

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  49. Content type: Study protocol

    Anorexia nervosa (AN) is a serious psychiatric illness that begins most of the time during adolescence. An early and efficacious intervention is crucial to minimize the risk of the illness becoming chronic and...

    Authors: Benjamin Carrot, Jeanne Duclos, Caroline Barry, Leslie Radon, Anne-Solène Maria, Irène Kaganski, Zorica Jeremic, Vesper Barton-Clegg, Maurice Corcos, Malaïka Lasfar, Priscille Gerardin, Aurélie Harf, Marie-Rose Moro, Corinne Blanchet and Nathalie Godart

    Citation: Trials 2019 20:249

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  50. Content type: Study protocol

    Venous leg ulcers are slow-healing wounds with a high recurrence rate of 70% and a 60% risk of becoming chronic. Signs and symptoms such as pain or exudate are not only a burden on those affected but also on t...

    Authors: Sebastian Probst, Lara Allet, Jocelyne Depeyre, Sophie Colin and Monika Buehrer Skinner

    Citation: Trials 2019 20:243

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