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  1. Children with sickle cell disease (SCD) frequently and unpredictably present to the emergency department (ED) with pain. The painful event is the hallmark acute clinical manifestation of SCD, characterised by ...

    Authors: Michael Joseph Barrett, John Cronin, Adrian Murphy, Siobhan McCoy, John Hayden, SinéadNic an Fhailí, Tim Grant, Abel Wakai, Corrina McMahon, Sean Walsh and Ronan O’Sullivan
    Citation: Trials 2012 13:74
  2. Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the comp...

    Authors: Mirella Ruggeri, Chiara Bonetto, Antonio Lasalvia, Giovanni De Girolamo, Angelo Fioritti, Paola Rucci, Paolo Santonastaso, Giovanni Neri, Francesca Pileggi, Daniela Ghigi, Maurizio Miceli, Silvio Scarone, Angelo Cocchi, Stefano Torresani, Carlo Faravelli, Christa Zimmermann…
    Citation: Trials 2012 13:73
  3. The optimal strategy for abdominal wall closure has been an issue of ongoing debate. Available studies do not specifically enroll patients who undergo emergency laparotomy and thus do not consider the distinct...

    Authors: Nuh N Rahbari, Phillip Knebel, Meinhard Kieser, Thomas Bruckner, Detlef K Bartsch, Helmut Friess, Andre L Mihaljevic, Josef Stern, Markus K Diener, Sabine Voss, Inga Rossion, Markus W Büchler and Christoph M Seiler
    Citation: Trials 2012 13:72
  4. Patients with chronic fatigue syndrome experience extreme fatigue, which often leads to substantial limitations of occupational, educational, social and personal activities. Currently, there is no consensus re...

    Authors: Desirée CWM Vos-Vromans, Rob JEM Smeets, Leonie JM Rijnders, René RM Gorrissen, Menno Pont, Albère JA Köke, Minou WMGC Hitters, Silvia MAA Evers and André J Knottnerus
    Citation: Trials 2012 13:71
  5. Cognitive-behavioral therapy (CBT) is generally known to be efficacious in the treatment of social phobia when applied in RCTs, namely when the treatment manual is based on the Clark-Wells approach. However, l...

    Authors: Stephen Crawcour, Eric Leibing, Denise Ginzburg, Ulrich Stangier, Jörg Wiltink and Jürgen Hoyer
    Citation: Trials 2012 13:70
  6. Most people who stop smoking successfully for a few weeks will return to smoking again in the medium term. There are few effective interventions to prevent this relapse and none used routinely in clinical prac...

    Authors: Fujian Song, Richard Holland, Garry R Barton, Max Bachmann, Annie Blyth, Viv Maskrey, Paul Aveyard, Stephen Sutton, Jo Leonardi-Bee and Thomas H Brandon
    Citation: Trials 2012 13:69
  7. It is generally accepted that an active lifestyle is beneficial for cognition in children, adults and the elderly. Recently, studies using the rat animal model found that the pups of mothers who exercised duri...

    Authors: Elise L LeMoyne, Daniel Curnier, Samuel St-Jacques and Dave Ellemberg
    Citation: Trials 2012 13:68
  8. Procedural burn pain is the most intense acute pain and most likely type of burn injury pain to be undertreated due to the physician’s fear of the adverse effect of analgesia and lack of anesthetist present. A...

    Authors: Li Yuxiang, Tang Lu, Yu Jianqiang, Dai Xiuying, Zhou Wanfang, Zhang Wannian, Hu Xiaoyan, Xiao Shichu, Ni Wen, Ma Xiuqiang, Wu Yinsheng, Yao Ming, Mu Guoxia, Wang Guangyi, Han Wenjun, Xia Zhaofan…
    Citation: Trials 2012 13:67
  9. Nutritional status often deteriorates in Alzheimer’s disease (AD). Less is known about whether nutritional care reverses malnutrition and its harmful consequences in AD. The aim of this study is to examine whe...

    Authors: Satu K Jyvakorpi, Taija Puranen, Kaisu H Pitkala and Merja H Suominen
    Citation: Trials 2012 13:66
  10. Resuscitation at birth with 100% oxygen is known to increase the oxidative burden with concomitant deleterious effects. Although fractions of inspired oxygen (FiO2) < 100% are widely used in preterm infants, star...

    Authors: Denise Rook, Henk Schierbeek, Anne C van der Eijk, Mariangela Longini, Giuseppe Buonocore, Maximo Vento, Johannes B van Goudoever and Marijn J Vermeulen
    Citation: Trials 2012 13:65
  11. Drugs for inhalation are the cornerstone of therapy in obstructive lung disease. We have observed that up to 75 % of patients do not perform a correct inhalation technique. The inability of patients to correct...

    Authors: Francisca Leiva-Fernández, José Leiva-Fernández, Fernando Zubeldia-Santoyo, Antonio García-Ruiz, Daniel Prados-Torres and Pilar Barnestein-Fonseca
    Citation: Trials 2012 13:64
  12. The need for cost-effective interventions for people suffering from major depressive disorders is essential. Behavioral activation is an intervention that can largely benefit from the use of new mobile technol...

    Authors: Kien Hoa Ly, Per Carlbring and Gerhard Andersson
    Citation: Trials 2012 13:62
  13. There have been no major advances in tuberculosis (TB) drug development since the first East African/British Medical Research Council short course chemotherapy trial 35 years ago. Since then, the landscape for...

    Authors: Corinne SC Merle, Charalambos Sismanidis, Oumou Bah Sow, Martin Gninafon, John Horton, Olivier Lapujade, Mame Bocar Lo, Denis A Mitchinson, Christian Perronne, Francoise Portaels, Joseph Odhiambo, Piero Olliaro, Roxana Rustomjee, Christian Lienhardt and Katherine Fielding
    Citation: Trials 2012 13:61
  14. IVF is a costly treatment option for women, their partners, and the public. Therefore new therapies that improve reproductive and health outcomes are highly desirable. There is a growing body of research evalu...

    Authors: Caroline A Smith, Sheryl de Lacey, Michael Chapman, Julie Ratcliffe, Robert J Norman, Neil Johnson, Gavin Sacks, Jane Lyttleton and Clare Boothroyd
    Citation: Trials 2012 13:60

    The Erratum to this article has been published in Trials 2017 18:248

  15. The epidemic surge in hypertension in sub-Saharan Africa is not matched by clinical trials of antihypertensive agents in Black patients recruited in this area of the world. We mounted the Newer versus Older An...

    Authors: Augustine N Odili, Birinus Ezeala-Adikaibe, Mouhamadou B Ndiaye, Benedict C Anisiuba, Marius M Kamdem, Chinwuba K Ijoma, Joseph Kaptue, Hilaire J Boombhi, Philip M Kolo, Elvis N Shu, Lutgarde Thijs, Jan A Staessen, Babatunde A Omotoso, Samuel Kingue, Serigne A Ba, Daniel Lemogoum…
    Citation: Trials 2012 13:59
  16. Pentavalent antimonials (Sb5) and miltefosine are the first-line drugs for treating cutaneous leishmaniasis in Colombia; however, toxicity and treatment duration negatively impact compliance and cost, justifying ...

    Authors: Liliana López, Martha Robayo, Margarita Vargas and Iván D Vélez
    Citation: Trials 2012 13:58

    The Erratum to this article has been published in Trials 2017 18:408

  17. Postoperative surgical site infections cause substantial morbidity, prolonged hospitalization, costs and even mortality and remain one of the most frequent surgical complications. Approximately 14% to 30% of a...

    Authors: André L Mihaljevic, Christoph W Michalski, Mert Erkan, Carolin Reiser-Erkan, Carsten Jäger, Tibor Schuster, Christoph Schuhmacher, Jörg Kleeff and Helmut Friess
    Citation: Trials 2012 13:57
  18. The provision of appropriate medical and nursing care for people with dementia is a major challenge for the healthcare system in Germany. New models of healthcare provision need to be developed, tested and imp...

    Authors: Jochen René Thyrian, Thomas Fiß, Adina Dreier, Georgia Böwing, Aniela Angelow, Sven Lueke, Stefan Teipel, Steffen Fleßa, Hans Jörgen Grabe, Harald Jürgen Freyberger and Wolfgang Hoffmann
    Citation: Trials 2012 13:56
  19. Neointimal hyperplasia plays a pivotal role in the pathogenesis of in-stent restenosis in patients undergoing percutaneous coronary interventions. Drug-eluting balloons are a promising tool to prevent restenos...

    Authors: Francesco Burzotta, Marta Francesca Brancati, Carlo Trani, Italo Porto, Antonella Tommasino, Gianluigi De Maria, Giampaolo Niccoli, Antonio Maria Leone, Valentina Coluccia, Giovanni Schiavoni and Filippo Crea
    Citation: Trials 2012 13:55
  20. The use of lLaparoscopic liver resection in terms of time to functional recovery, length of hospital stay (LOS), long-term abdominal wall hernias, costs and quality of life (QOL) has never been studied in a ra...

    Authors: Ronald M van Dam, Edgar M Wong-Lun-Hing, Gerard JP van Breukelen, Jan HMB Stoot, Joost R van der Vorst, Marc HA Bemelmans, Steven WM Olde Damink, Kristoffer Lassen and Cornelis HC Dejong
    Citation: Trials 2012 13:54
  21. Shifts in clinical trial application rates over time indicate if the attractiveness of a country or region for the conduct of clinical trials is growing or decreasing. The purpose of this observational study w...

    Authors: Markus Hartmann
    Citation: Trials 2012 13:53
  22. Chronic lumbar radicular pain can be described as neuropathic pain along the distribution of a particular nerve root. The dorsal root ganglion has been implicated in its pathogenesis by giving rise to abnormal...

    Authors: Harsha Shanthanna, Philip Chan, James McChesney, James Paul and Lehana Thabane
    Citation: Trials 2012 13:52
  23. Pyoderma gangrenosum (PG) is a rare inflammatory skin disorder characterised by painful and rapidly progressing skin ulceration. PG can be extremely difficult to treat and patients often require systemic immun...

    Authors: Fiona F Craig, Kim S Thomas, Eleanor J Mitchell, Hywel C Williams, John Norrie, James M Mason and Anthony D Ormerod
    Citation: Trials 2012 13:51
  24. The Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) tool is intended to be used in the design phase of trials to help investigative teams design trials in-line with their purpose. Our team applied t...

    Authors: Daniel J Bratton, Andrew J Nunn, Fenella Wojnarowska, Gudula Kirtschig, Anna Sandell and Hywel C Williams
    Citation: Trials 2012 13:50
  25. Hypercoagulability, assessed by the thrombelastography (TEG) assay, has in several observational studies been associated with an increased risk of post-procedural thromboembolic complications. We hypothesize t...

    Authors: Sulman Rafiq, Pär Ingemar Johansson, Mette Zacho, Trine Stissing, Klaus Kofoed, Nikolaj Bang Lilleør and Daniel Andreas Steinbrüchel
    Citation: Trials 2012 13:48
  26. Male infertility is a significant contributor to the need for fertility treatment. Treatment currently involves correcting any identifiable adverse lifestyle factors in men with suboptimal sperm parameters, an...

    Authors: M Waseem Osman, llias Nikolopoulos, Zeina Haoula, Jayaprakasan Kannamannadiar and William Atiomo
    Citation: Trials 2012 13:47
  27. Migraine is one of the most frequent headache diseases and impairs patients’ quality of life. Up to now, many randomized studies reported efficacy of prophylactic therapy with medications such as beta-blockers...

    Authors: Andreas Totzeck, Susanne Unverzagt, Maja Bak, Pierre Augst, Hans-Christoph Diener and Charly Gaul
    Citation: Trials 2012 13:46
  28. Pancreatoduodenectomy is one of the most complex abdominal operations, usually performed for tumors of the periampullary region and chronic pancreatitis. Leakage of pancreatic juice from the pancreatoenteric a...

    Authors: Ulrich Friedrich Wellner, Sabine Brett, Thomas Bruckner, Ronald Limprecht, Inga Rossion, Christoph Seiler, Olivia Sick, Inga Wegener, Ulrich Theodor Hopt and Tobias Keck
    Citation: Trials 2012 13:45
  29. In the last few years, excessive internet use and computer gaming have increased dramatically. Salience, mood modification, tolerance, withdrawal symptoms, conflict, and relapse have been defined as diagnostic...

    Authors: Susanne Jäger, Kai W Müller, Christian Ruckes, Tobias Wittig, Anil Batra, Michael Musalek, Karl Mann, Klaus Wölfling and Manfred E Beutel
    Citation: Trials 2012 13:43
  30. Postoperative atrial fibrillation (POAF) is the most common complication after coronary artery bypass grafting (CABG). The preventive effect of magnesium on POAF is not well known. This meta-analysis was under...

    Authors: Wan-Jie Gu, Zhen-Jie Wu, Peng-Fei Wang, Lynn Htet Htet Aung and Rui-Xing Yin
    Citation: Trials 2012 13:41
  31. Frequent chronic obstructive pulmonary disease (COPD) exacerbation is a major cause of hospital admission and mortality. It has been reported that Traditional Chinese Medicine (TCM) may relieve COPD symptoms a...

    Authors: Wang Haifeng, Li Jiansheng, Li Suyun, Yu Xueqing, Zhang Hailong, Wang Zhiwan, Wu Qiyi, Zhang Pankui, Wang Zhongchao, Li Fenglei and Yan Haihong
    Citation: Trials 2012 13:40
  32. The end of life for cancer patients is the ultimate stage of the disease, and care in this setting is important as it can improve the wellbeing not only of patients, but also the patients' family and close fri...

    Authors: Anne-Lise Poirier, Fabrice Kwiatkowski, Jean-Marie Commer, Bénédicte D'Aillières, Virginie Berger, Mariette Mercier and Franck Bonnetain
    Citation: Trials 2012 13:39
  33. Substantial data indicate potential health consequences of untreated postpartum depression (PPD) on the mother, infant, and family. Studies have evaluated interpersonal psychotherapy (IPT) as treatment for PPD...

    Authors: Cindy-Lee Dennis, Paula Ravitz, Sophie Grigoriadis, Melissa Jovellanos, Ellen Hodnett, Lori Ross and John Zupancic
    Citation: Trials 2012 13:38
  34. Non-allergic rhinopathy (NAR), formerly known as vasomotor rhinitis, is a non-allergic and non-infectious chronic disease that is accompanied by nasal hyperemia, rhinorrhea, and no increase in the number of eo...

    Authors: Kyu Seok Kim, Sang Gyu Go and Yoon-Bum Kim
    Citation: Trials 2012 13:37
  35. The zygoma plays an important role in the facial contour for both cosmetic and functional reasons; therefore zygomatic bone injuries should be properly diagnosed and adequately treated. Comparison of various s...

    Authors: Majeed Rana, Riaz Warraich, Salman Tahir, Asifa Iqbal, Constantin von See, André M Eckardt and Nils-Claudius Gellrich
    Citation: Trials 2012 13:36
  36. Well-designed and properly executed randomized controlled trials (RCTs) provide the best evidence on the efficacy of healthcare interventions. Mental health has a strong tradition of using trial to evaluate tr...

    Authors: Marianna Purgato, Clive Adams and Corrado Barbui
    Citation: Trials 2012 13:35
  37. Many older people with neuropsychiatric disorders such as Alzheimer's disease and frontotemporal dementia suffer from sleeping problems and often show nocturnal restlessness. Professionals and informal carers ...

    Authors: Arnoldien J van Os, Leelie Aziz, Dorus Schalkwijk, Jos MGA Schols and Rob A de Bie
    Citation: Trials 2012 13:34
  38. Obesity, which is described as excessive or abnormal body fat, increases the risk of diet-related diseases. In Korea and around the world, the prevalence of obesity has grown annually from 1998 to 2008. This g...

    Authors: Sunju Park, Jeong-Su Park, ChunHoo Cheon, Yong Joon Yang, Changsuk An, Bo-Hyoung Jang, Yun-Kyung Song, Hoyeon Go, Ju Ah Lee, Yongcheol Shin and Seong-Gyu Ko
    Citation: Trials 2012 13:33
  39. Almost all cognitive functions decline with age. Results of previous studies have shown that cognitive training related to everyday life (reading aloud and solving simple arithmetic calculations), namely learn...

    Authors: Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Takayuki Nozawa, Atsushi Sekiguchi, Haruka Nouchi and Ryuta Kawashima
    Citation: Trials 2012 13:32
  40. Half of all lower limb deep vein thrombi (DVT) in symptomatic ambulatory patients are located in the distal (calf) veins. While proximal disease warrants therapeutic anticoagulation to reduce the associated ri...

    Authors: Daniel Horner, Kerstin Hogg, Richard Body, Michael J Nash and Kevin Mackway-Jones
    Citation: Trials 2012 13:31
  41. Despite continual improvements in the management of acute coronary syndromes, adherence to guideline-based medications remains suboptimal. We aim to improve adherence with guideline-based therapy following acu...

    Authors: Daniel D L Bernal, Leanne Stafford, Luke R E Bereznicki, Ronald L Castelino, Patricia M Davidson and Gregory M Peterson
    Citation: Trials 2012 13:30
  42. Second-generation drug-eluting stents (DES) have raised the bar of clinical performance. These stents are mostly made from cobalt chromium alloy. A newer generation DES has been developed from platinum chromiu...

    Authors: Kyung Woo Park, Byoung-Eun Park, Si-Hyuck Kang, Jin-Joo Park, Seung-Pyo Lee, Kwang Soo Cha, Jay Young Rhew, Hui-Kyoung Jeon, Eun Seok Shin, Ju Hyeon Oh, Myung-Ho Jeong, Sanghyun Kim, Kyung-Kuk Hwang, Jung-Han Yoon, Sung Yun Lee, Tae-Ho Park…
    Citation: Trials 2012 13:29
  43. In order to facilitate multinational clinical research, regulatory requirements need to become international and harmonised. The EU introduced the Directive 2001/20/EC in 2004, regulating investigational medic...

    Authors: Christian Gluud, Christine Kubiak, Kate Whitfield, Jane Byrne, Karl-Heinz Huemer, Steffen Thirstrup, Christian Libersa, Béatrice Barraud, Xina Grählert, Gabriele Dreier, Sebastian Geismann, Wolfgang Kuchinke, Zsuza Temesvari, Gyorgy Blasko, Gabriella Kardos, Timothy O'Brien…
    Citation: Trials 2012 13:27
  44. Approximately 80,000 patients each year are admitted to UK hospitals with an acute stroke and are immobile. At least 10% will develop a proximal Deep Vein Thrombosis in the first month and 1.5% a pulmonary emb...

    Authors: Martin Dennis, Peter Sandercock, John Reid, Catriona Graham and John Forbes
    Citation: Trials 2012 13:26
  45. An aging population and better management of various heart diseases explain the exponential growth in incidence and prevalence of chronic heart failure, with poor prognosis and heavy health costs. Medical mana...

    Authors: Romain Eschalier, Frédéric Jean, Bruno Pereira, Séverine Monzy, Charles Vorilhon, Valérie Mactoux, Bernard Citron, Vincent Sapin, Pascal Motreff and Jean R Lusson
    Citation: Trials 2012 13:25

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