Skip to main content

Articles

Page 185 of 207

  1. Despite bronchiectasis being increasingly recognised as an important cause of chronic respiratory morbidity in both indigenous and non-indigenous settings globally, high quality evidence to inform management i...

    Authors: Anne B Chang, Keith Grimwood, Colin F Robertson, Andrew C Wilson, Peter P van Asperen, Kerry-Ann F O’Grady, Theo P Sloots, Paul J Torzillo, Emily J Bailey, Gabrielle B McCallum, Ian B Masters, Catherine A Byrnes, Mark D Chatfield, Helen M Buntain, Ian M Mackay and Peter S Morris
    Citation: Trials 2012 13:156
  2. More than 100 surgical approaches to treat rectal prolapse have been described. These can be done through the perineum or transabdominally. Delorme’s procedure is the most frequently used perineal, resection r...

    Authors: Simone Rothenhoefer, Florian Herrle, Alexander Herold, Andreas Joos, Dieter Bussen, Meinhard Kieser, Petra Schiller, Christina Klose, Christoph M Seiler, Peter Kienle and Stefan Post
    Citation: Trials 2012 13:155
  3. Trials of complex interventions are criticized for being ‘black box’, so the UK Medical Research Council recommends carrying out a process evaluation to explain the trial findings. We believe it is good practi...

    Authors: Aileen Grant, Tobias Dreischulte, Shaun Treweek and Bruce Guthrie
    Citation: Trials 2012 13:154
  4. The successful Greater Green Triangle Diabetes Prevention Program (GGT DPP), a small implementation trial, has been scaled-up to the Victorian state-wide ‘Life!’ programme with over 10,000 individuals enrolled...

    Authors: Edward D Janus, James D Best, Nathalie Davis-Lameloise, Benjamin Philpot, Andrea Hernan, Catherine M Bennett, Sharleen O’Reilly, Rob Carter, Erkki Vartiainen and James A Dunbar
    Citation: Trials 2012 13:152
  5. Computerised cognitive behaviour therapy (cCBT) involves standardised, automated, interactive self-help programmes delivered via a computer. Randomised controlled trials (RCTs) and observational studies have s...

    Authors: Lina Gega, Louise Swift, Garry Barton, Gillian Todd, Nesta Reeve, Kelly Bird, Richard Holland, Amanda Howe, Jon Wilson and Jo Molle
    Citation: Trials 2012 13:151
  6. Adverse drug events are responsible for up to 7% of all admissions to acute care hospitals. At least 58% of these are preventable, resulting from incomplete drug information, prescribing or dispensing errors, ...

    Authors: Robyn Tamblyn, Allen R Huang, Ari N Meguerditchian, Nancy E Winslade, Christian Rochefort, Alan Forster, Tewodros Eguale, David Buckeridge, André Jacques, Kiyuri Naicker and Kristen E Reidel
    Citation: Trials 2012 13:150
  7. Over the last 30 years the number of people who drink alcohol at harmful levels has increased in many countries. There have also been large increases in rates of sexually transmitted infections. Available evid...

    Authors: Rahil Sanatinia, Barbara Barrett, Sarah Byford, Madeleine Dean, John Green, Rachel Jones, Baptiste Leurent, Anne Lingford-Hughes, Michael Sweeting, Robin Touquet, Peter Tyrer, Helen Ward and Mike J Crawford
    Citation: Trials 2012 13:149
  8. Coronary artery disease remains the dominant cause of mortality in developed countries. While platelets have been recognized to play a pivotal role in atherothrombosis, the ideal antiplatelet regime after coro...

    Authors: Hrvoje Gasparovic, Mate Petricevic, Tomislav Kopjar, Zeljko Djuric, Lucija Svetina and Bojan Biocina
    Citation: Trials 2012 13:148
  9. We describe the rationale and protocol for a randomized noninferiority controlled trial (RCT) to determine if the Flexi-T380(+) copper intrauterine contraceptive device (IUD) is comparable in terms of effectiv...

    Authors: Wendy V Norman, Jessica L Chiles, Caroline A Turner, Rollin Brant, Andra Aslan and Janusz Kaczorowski
    Citation: Trials 2012 13:147
  10. Adaptive designs allow planned modifications based on data accumulating within a study. The promise of greater flexibility and efficiency stimulates increasing interest in adaptive designs from clinical, acade...

    Authors: John A Kairalla, Christopher S Coffey, Mitchell A Thomann and Keith E Muller
    Citation: Trials 2012 13:145
  11. Hepatocellular carcinoma is a primary malignant tumor of the liver that accounts for an important health problem worldwide. Only 10 to 15% of hepatocellular carcinoma patients are suitable candidates for treat...

    Authors: Beatrijs A Seinstra, Luc Defreyne, Bieke Lambert, Marnix GEHH Lam, Helena M Verkooijen, Karel J van Erpecum, Bart van Hoek, Arian R van Erkel, Minneke J Coenraad, Imad Al Younis, Hans van Vlierberghe and Maurice AAJ van den Bosch
    Citation: Trials 2012 13:144
  12. There is a lack of evidence for the effective management of dental caries in children’s primary teeth. The trial entitled ‘Filling Children’s Teeth: Indicated Or Not?’ (FiCTION) was designed to examine the cli...

    Authors: Zoe Marshman, Nicola Innes, Chris Deery, Melanie Hall, Chris Speed, Gail Douglas, Jan Clarkson and Helen Rodd
    Citation: Trials 2012 13:143
  13. Dementia syndromes are under-diagnosed and under-treated in primary care. Earlier recognition of and response to dementia syndrome is likely to enhance the quality of life of people with dementia, but general ...

    Authors: Steve Iliffe, Tamar Koch, Priya Jain, Frances Lefford, Geoffrey Wong, Alex Warner and Jane Wilcock
    Citation: Trials 2012 13:142
  14. Asthma is a major cause of pediatric morbidity and mortality. In acute exacerbations of asthma, corticosteroids reduce relapses, subsequent hospital admission and the need for ß2-agonist therapy. Prednisolone is ...

    Authors: John Cronin, Una Kennedy, Siobhan McCoy, Sinéad Nic an Fhailí, Gloria Crispino-O’Connell, John Hayden, Abel Wakai, Sean Walsh and Ronan O’Sullivan
    Citation: Trials 2012 13:141
  15. A 2003 survey suggested the number of noncommercial trials in the UK was declining. Formation of the NIHR in 2006 and increased research spending by the Department of Health may have increased the number of no...

    Authors: James Raftery, Eleanor Fairbank, Lisa Douet, Louise Dent, Alison Price, Ruairidh Milne and Tom Walley
    Citation: Trials 2012 13:140
  16. Depression is up to two to three times as common in people with long-term conditions. It negatively affects medical management of disease and self-care behaviors, and leads to poorer quality of life and high c...

    Authors: Peter A Coventry, Karina Lovell, Chris Dickens, Peter Bower, Carolyn Chew-Graham, Andrea Cherrington, Charlotte Garrett, Chris J Gibbons, Clare Baguley, Kate Roughley, Isabel Adeyemi, Chris Keyworth, Waquas Waheed, Mark Hann, Linda Davies, Farheen Jeeva…
    Citation: Trials 2012 13:139
  17. Clinicians, patients, governments, third-party payers, and the public take for granted that diagnostic tests are accurate, safe and effective. However, we may be seriously misled if we are relying on robust st...

    Authors: Marc Rodger, Tim Ramsay and Dean Fergusson
    Citation: Trials 2012 13:137
  18. Previous studies have documented strategies to promote off-label use of drugs using journal publications and other means. Few studies have presented internal company communications that discussed financial rea...

    Authors: S Swaroop Vedula, Palko S Goldman, Ilyas J Rona, Thomas M Greene and Kay Dickersin
    Citation: Trials 2012 13:136
  19. State of the art sedation concepts on intensive care units (ICU) favor propofol for a time period of up to 72 h and midazolam for long-term sedation. However, intravenous sedation is associated with complicati...

    Authors: Jens Soukup, Antje Selle, Andreas Wienke, Jörg Steighardt, Nana-Maria Wagner and Patrick Kellner
    Citation: Trials 2012 13:135
  20. Aging is associated with chronic low-grade inflammatory activity with an elevation of cytokine levels. An association between regular physical activity and reduction of blood levels of anti-inflammatory cytoki...

    Authors: Daniele S Pereira, Bárbara Z Queiroz, Elvis CC Mateo, Alexandra M Assumpção, Diogo C Felício, Aline S Miranda, Daniela MC Anjos, Fabianna Jesus-Moraleida, Rosângela C Dias, Danielle AG Pereira, Antônio L Teixeira and Leani SM Pereira
    Citation: Trials 2012 13:134
  21. After diagnosis of a dementing illness, patients and their spouses have many concerns related to the disease and their future. This often leads to poor psychological well-being and reduced health-related quali...

    Authors: Marja-Liisa Laakkonen, Eeva H Hölttä, Niina Savikko, Timo E Strandberg, Merja Suominen and Kaisu H Pitkälä
    Citation: Trials 2012 13:133
  22. The selection of appropriate outcomes or domains is crucial when designing clinical trials in order to compare directly the effects of different interventions in ways that minimize bias. If the findings are to...

    Authors: Paula R Williamson, Douglas G Altman, Jane M Blazeby, Mike Clarke, Declan Devane, Elizabeth Gargon and Peter Tugwell
    Citation: Trials 2012 13:132
  23. Osteoarthritis (OA) is a common health issue worldwide in the aging population who are also commonly deficient in vitamin D. Our previous study suggested that higher serum 25-(OH)D levels were associated with ...

    Authors: Yuelong Cao, Graeme Jones, Flavia Cicuttini, Tania Winzenberg, Anita Wluka, James Sharman, Kay Nguo and Changhai Ding
    Citation: Trials 2012 13:131
  24. The incidence of postoperative nausea and vomiting (PONV) is 50% to 80% after neurosurgery. The common prophylactic treatment for postoperative nausea and vomiting is a triple therapy of droperidol, promethazi...

    Authors: Sergio Bergese, Adolfo Viloria, Alberto Uribe, Alejandra Antor and Soledad Fernandez
    Citation: Trials 2012 13:130
  25. Extended smoking cessation follow-up after hospital discharge significantly increases abstinence. Hospital smoke-free policies create a period of ‘forced abstinence’ for smokers, thus providing an opportunity ...

    Authors: Jeffrey L Fellows, Richard Mularski, Lisa Waiwaiole, Kim Funkhouser, Julie Mitchell, Kathleen Arnold and Sabrina Luke
    Citation: Trials 2012 13:129
  26. Hospitalized smokers often quit smoking, voluntarily or involuntarily; most relapse soon after discharge. Extended follow-up counseling can help prevent relapse. However, it is difficult for hospitals to provi...

    Authors: Sharon Cummins, Shu-Hong Zhu, Anthony Gamst, Carrie Kirby, Kendra Brandstein, Hillary Klonoff-Cohen, Edward Chaplin, Timothy Morris, Gregory Seymann and Joshua Lee
    Citation: Trials 2012 13:128
  27. Post-discharge support is a key component of effective treatment for hospitalized smokers, but few hospitals provide it. Many hospitals and care settings fax-refer smokers to quitlines for follow-up; however, ...

    Authors: Kimber P Richter, Babalola Faseru, Laura M Mussulman, Edward F Ellerbeck, Theresa I Shireman, Jamie J Hunt, Beatriz H Carlini, Kristopher J Preacher, Candace L Ayars and David J Cook
    Citation: Trials 2012 13:127
  28. Hospitalization may be a particularly important time to promote smoking cessation, especially in the immediate post-discharge period. However, there are few studies to date that shed light on the most effectiv...

    Authors: Ellie Grossman, Donna Shelley, R Scott Braithwaite, Iryna Lobach, Ana Goffin, Erin Rogers and Scott Sherman
    Citation: Trials 2012 13:126
  29. The objectives of this smoking cessation study among hospitalized smokers are to: 1) determine provider and patient receptivity, barriers, and facilitators to implementing the nurse-administered, inpatient Tob...

    Authors: Sonia A Duffy, David L Ronis, Marita G Titler, Frederic C Blow, Neil Jordan, Patricia L Thomas, Gay L Landstrom, Lee A Ewing and Andrea H Waltje
    Citation: Trials 2012 13:125
  30. A hospital admission offers smokers an opportunity to quit. Smoking cessation counseling provided in the hospital is effective, but only if it continues for more than one month after discharge. Providing smoki...

    Authors: Sandra J Japuntich, Susan Regan, Joseph Viana, Justyna Tymoszczuk, Michele Reyen, Douglas E Levy, Daniel E Singer, Elyse R Park, Yuchiao Chang and Nancy A Rigotti
    Citation: Trials 2012 13:124
  31. E-health tools are a new mechanism to expand patient care, allowing supplemental resources to usual care, including enhanced patient-provider communication. These applications to smoking cessation have yet to ...

    Authors: Kathleen F Harrington, Julie A McDougal, Maria Pisu, Bin Zhang, Rajani S Sadasivam, Thomas K Houston and William C Bailey
    Citation: Trials 2012 13:123
  32. We describe the study design, procedures, and development of the risk counseling protocol used in a randomized controlled trial to evaluate the impact of genetic testing for diabetes mellitus (DM) on psycholog...

    Authors: Corrine I Voils, Cynthia J Coffman, David Edelman, Matthew L Maciejewski, Janet M Grubber, Azita Sadeghpour, Alex Cho, Jamiyla McKenzie, Francoise Blanpain, Maren Scheuner, Margarete Sandelowski, M Patrick Gallagher, Geoffrey S Ginsburg and William S Yancy Jr
    Citation: Trials 2012 13:121
  33. Reviews have repeatedly noted important methodological issues in the conduct and reporting of cluster randomized controlled trials (C-RCTs). These reviews usually focus on whether the intracluster correlation ...

    Authors: Noah M Ivers, Ilana J Halperin, Jan Barnsley, Jeremy M Grimshaw, Baiju R Shah, Karen Tu, Ross Upshur and Merrick Zwarenstein
    Citation: Trials 2012 13:120
  34. Negative pressure wound therapy (NPWT) is widely promoted as a treatment for full thickness wounds; however, there is a lack of high-quality research evidence regarding its clinical and cost effectiveness. A t...

    Authors: Rebecca L Ashby, Jo C Dumville, Marta O Soares, Elizabeth McGinnis, Nikki Stubbs, David J Torgerson and Nicky Cullum
    Citation: Trials 2012 13:119
  35. Luteal support with progesterone is necessary for successful implantation of the embryo following egg collection and embryo transfer in an in-vitro fertilization (IVF) cycle. Progesterone has been used for as ...

    Authors: Rafet Gazvani, Richard Russell, Yasmin Sajjad and Zarko Alfirevic
    Citation: Trials 2012 13:118
  36. Despite limited effectiveness of short-term psychotherapy for chronic depression, there is a lack of trials of long-term psychotherapy. Our study is the first to determine the effectiveness of controlled long-...

    Authors: Manfred E Beutel, Marianne Leuzinger-Bohleber, Bernhard Rüger, Ulrich Bahrke, Alexa Negele, Antje Haselbacher, Georg Fiedler, Wolfram Keller and Martin Hautzinger
    Citation: Trials 2012 13:117
  37. This article is part of a series of papers examining ethical issues in cluster randomized trials (CRTs) in health research. In the introductory paper in this series, we set out six areas of inquiry that must b...

    Authors: Antonio Gallo, Charles Weijer, Angela White, Jeremy M Grimshaw, Robert Boruch, Jamie C Brehaut, Allan Donner, Martin P Eccles, Andrew D McRae, Raphael Saginur, Merrick Zwarenstein and Monica Taljaard
    Citation: Trials 2012 13:116
  38. Lifestyle factors playing a role in the development of late-life disability may be modifiable. There is a need for robust evidence about the potential for prevention of disability through behavior change inter...

    Authors: Linda Clare, John V Hindle, Ian R Jones, Jeanette M Thom, Sharon M Nelis, Barry Hounsome and Christopher J Whitaker
    Citation: Trials 2012 13:115
  39. Single-limb knee extension exercises have been found to be effective at improving lower extremity exercise capacity in patients with chronic obstructive pulmonary disease (COPD). Since the positive local physi...

    Authors: Andre Nyberg, Britta Lindström and Karin Wadell
    Citation: Trials 2012 13:114
  40. Seventy percent of women in Scotland have at least one baby, making pregnancy an opportunity to help most young women quit smoking before their own health is irreparably compromised. By quitting during pregnan...

    Authors: David M Tappin, Linda Bauld, Carol Tannahill, Linda de Caestecker, Andrew Radley, Alex McConnachie, Kathleen Boyd, Andrew Briggs, Liz Grant, Alan Cameron, Susan MacAskill, Lesley Sinclair, Brenda Friel and Tim Coleman
    Citation: Trials 2012 13:113
  41. Many postnatal women are insufficiently physically active in the year after childbirth and could benefit from interventions to increase activity levels. However, there is limited information about the efficacy...

    Authors: Alyssa S Gilinsky, Adrienne R Hughes and Rhona J McInnes
    Citation: Trials 2012 13:112
  42. There are many challenges involved in running randomised controlled dietary intervention trials that investigate health outcomes. The aim of this paper was to evaluate the recruitment process, retention of par...

    Authors: Georgina E Crichton, Peter RC Howe, Jonathan D Buckley, Alison M Coates, Karen J Murphy and Janet Bryan
    Citation: Trials 2012 13:111
  43. Postpartum haemorrhage (PPH) remains a leading cause of maternal mortality worldwide. In Denmark 2% of parturients receive blood transfusion. During the course of bleeding fibrinogen (coagulation factor I) may...

    Authors: Anne Juul Wikkelsoe, Arash Afshari, Jakob Stensballe, Jens Langhoff-Roos, Charlotte Albrechtsen, Kim Ekelund, Gabriele Hanke, Heidi Fosgrau Sharif, Anja U Mitchell, Jens Svare, Ane Troelstrup, Lars Møller Pedersen, Jeannet Lauenborg, Mette Gøttge Madsen, Birgit Bødker and Ann M Møller
    Citation: Trials 2012 13:110
  44. Chronic obstructive pulmonary disease (COPD) has become a major public health problem worldwide because of its high and increasing prevalence, morbidity, and mortality. Little attention has been paid to earlie...

    Authors: Wang Minghang, Li Jiansheng, Li Suyun, Wang Haifeng, Yu Xueqing and Zhang Hailong
    Citation: Trials 2012 13:109
  45. In The Netherlands, helmet therapy is a commonly used treatment in infants with skull deformation (deformational plagiocephaly or deformational brachycephaly). However, evidence of the effectiveness of this tr...

    Authors: Renske M van Wijk, Magda M Boere-Boonekamp, Catharina GM Groothuis-Oudshoorn, Leo A van Vlimmeren and Maarten J IJzerman
    Citation: Trials 2012 13:108
  46. Neck pain is one of the chief symptoms of cervical spondylosis (CS). Acupuncture is a well-accepted and widely used complementary therapy for the management of neck pain caused by CS. In this paper, we present...

    Authors: Zhao-Hui Liang, Zhong Di, Shuo Jiang, Shu-Jun Xu, Xiao-Ping Zhu, Wen-Bin Fu and Ai-Ping Lu
    Citation: Trials 2012 13:107

Annual Journal Metrics

  • 2022 Citation Impact
    2.5 - 2-year Impact Factor
    2.5 - 5-year Impact Factor
    0.827 - SNIP (Source Normalized Impact per Paper)
    0.814 - SJR (SCImago Journal Rank)

    2023 Speed
    33 days submission to first editorial decision for all manuscripts (Median)
    129 days submission to accept (Median)

    2023 Usage 
    6,282,238 downloads
    5,569 Altmetric mentions