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  1. Arteriosclerotic vascular disease manifests as heart disease, stroke, aortic aneurysms, and peripheral vascular disease, and is a growing problem world-wide. The preventive efforts made so far have demonstrate...

    Authors: W Virgil Brown
    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:12
  2. Only a few randomized clinical trials have been performed so far in heart transplant recipients, mainly because of the relatively small number of heart transplants performed worldwide each year. The main focus...

    Authors: Maria Rosa Costanzo
    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:45
  3. The Randomized Aldactone Evaluation Study (RALES) randomized 822 patients to receive 25 mg spironolactone daily and 841 to receive placebo. The primary endpoint was death from all causes. Randomization began o...

    Authors: Janet Wittes, Jolie Palensky, Debra Asner, Desmond Julian, Jean-Pierre Boissel, Curt D Furberg, Henri Kulbertus, Stuart Pocock and Barbara Roniker
    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:59
  4. PREVENT was the first prospective, randomized placebo-controlled study of intracoronary beta radiotherapy with 32P. A total of 105 patients with de novo or restenotic lesions, treated by stenting or balloon angio...

    Authors: Albert E Raizner and Grzegorz L Kaluza
    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:16
  5. The importance of low-density lipoprotein (LDL) control in the management of patients at high risk of cardiovascular events is unquestionable. The major statin trials have shown that the benefits of LDL loweri...

    Authors: Sergio Fazio and MacRae F Linton
    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:8
  6. The fundamental methodological deficiency of megatrials is deliberate reduction of experimental control in order to maximize recruitment and compliance of subjects. Hence, typical megatrials recruit pathologic...

    Authors: Bruce G Charlton
    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:2
  7. As the population ages the number of elderly patients presenting with acute myocardial infarction (AMI) will continue to increase. There has been no head-to-head trial of thrombolytic therapy versus primary pe...

    Authors: Vincent S DeGeare and Cindy L Grines
    Citation: Trials 2000 1:146
  8. Large scale clinical trials demonstrate significant reductions in cardiovascular event rates with statin therapy. The observed benefit of statin therapy, however, may be larger in these trials than that expect...

    Authors: Gavin J Blake and Paul M Ridker
    Citation: Trials 2000 1:161
  9. 1. To assess the long-term effectiveness of a comprehensive cardiac rehabilitation programme on quality of life and survival in patients with a large spectrum of cardiovascular diseases (myocardial infarction,...

    Authors: Cornel Pater, Carl Ditlef Jacobsen, Arnfinn Rollag, Leiv Sandvik, Jan Erikssen and Else Karin Kogstad
    Citation: Trials 2000 1:177
  10. Chronic heart failure (CHF) is a common condition with a poor prognosis. It is associated with poor exercise tolerance and debilitating symptoms. These symptoms appear to be associated with pathophysiological ...

    Authors: Andrew JS Coats
    Citation: Trials 2000 1:155
  11. Gene therapy using in vivo recombinant adenovirus-mediated gene transfer is an effective technique that offers great potential to improve existing drug treatments for the complex cardiovascular diseases of heart ...

    Authors: Andrea D Eckhart and Walter J Koch
    Citation: Trials 2000 1:131
  12. Lipid disorders are associated with atherosclerotic vascular disease, and therapy is associated with a substantial reduction in cardiovascular events. Current approaches to the treatment of lipid disorders are...

    Authors: Masa-aki Kawashiri and Daniel J Rader
    Citation: Trials 2000 1:120
  13. Despite the major advances in medical drug therapy, heart failure remains a syndrome associated with high mortality and morbidity. Biventricular or left ventricular (LV) short atrioventricular (AV) delay pacin...

    Authors: Jayne A Morris-Thurgood and Michael P Frenneaux
    Citation: Trials 2000 1:107
  14. Surrogate outcomes are frequently used in cardiovascular disease research. A concern is that changes in surrogate markers may not reflect changes in disease outcomes. Two recent clinical trials (Heart and Estr...

    Authors: Ralph B D'Agostino Jr
    Citation: Trials 2000 1:76
  15. Surrogate end-points of cardiovascular disease can provide useful information in cross-sectional, prospective and interventional studies. They provide information on association with risk factors, natural hist...

    Authors: Jonathan Valabhji and Robert S Elkeles
    Citation: Trials 2000 1:72
  16. Whether it matters how pressure is lowered has been debated since antihypertensive drugs proved to prevent cardiovascular events. However, in clinical trials, while the stroke benefit predicted by a given diff...

    Authors: Michael H Alderman
    Citation: Trials 2000 1:69
  17. Direct myocardial cell protection in patients with unstable angina or evolving myocardial infarction (MI) could prevent cell necrosis or reduce its extent, and minimize the risk of MI and death associated with...

    Authors: Pierre Theroux, Bernard R Chaitman, Leif Erhardt, Andreas Jessel, Thomas Meinertz, Wolf-Ulrich Nickel, John S Schroeder, Gianni Tognoni, Harvey White and James T Willerson
    Citation: Trials 2000 1:59
  18. The results of recent randomized trials to test the influence of antioxidants on coronary-event rates and prognosis in patients with coronary-artery disease were disappointing. In none of these studies did the...

    Authors: Ascan Warnholtz and Thomas Münzel
    Citation: Trials 2000 1:38
  19. The present review assesses the data on long-term outcome after coronary stenting. Histological, angiographical and intravascular imaging data have shown that the insertion of stents constitutes only a transie...

    Authors: Adnan Kastrati, Donald Hall and Albert Schömig
    Citation: Trials 2000 1:48
  20. Although the TIMI (Thrombolysis In Myocardial Infarction) flow grade classification scheme is widely used to assess angiographic outcomes, it is limited by poor reproducibility and its categoric nature. The co...

    Authors: Mark A Appleby, Andrew D Michaels, Michael Chen and C Gibson Michael
    Citation: Trials 2000 1:31
  21. This symposium provided a useful forum for the discussion of issues relating to the design and conduct of clinical trials. There is a need for greater awareness of the complexity of modern day trials, in which...

    Authors: Rachel N Johnatty
    Citation: Trials 2000 1:55
  22. Noninferiority trials are intended to show that the effect of a new treatment is not worse than that of an active control by more than a specified margin. These trials have a number of inherent weaknesses that...

    Authors: Steven M Snapinn
    Citation: Trials 2000 1:19

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