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  1. Periodontal disease (PD) is an infectious clinical entity characterized by the destruction of supporting tissues of the teeth as the result of a chronic inflammatory response in a susceptible host. It has been...

    Authors: Jorge H Ramírez, Roger M Arce and Adolfo Contreras
    Citation: Trials 2011 12:46
  2. Previous interventions to increase physical activity and reduce cardiovascular risk factors have been targeted at individuals with established disease; less attention has been given to intervention among indiv...

    Authors: Robert J Petrella, Kuni Aizawa, Kevin Shoemaker, Tom Overend, Len Piche, Mauricio Marin, Sheree Shapiro and Sophie Atkin
    Citation: Trials 2011 12:45
  3. Heart failure(HF) and atrial fibrillation(AF) frequently coexist in the same patient and are associated with increased mortality and frequent hospitalizations. As the concomitance of AF and HF is often associa...

    Authors: Giovanni Luca Botto, Giuseppe Boriani, Stefano Favale, Maurizio Landolina, Giulio Molon, Claudio Tondo, Mauro Biffi, Giuseppe Grandinetti, Paolo De Filippo, Giovanni Raciti and Luigi Padeletti
    Citation: Trials 2011 12:44
  4. Homeopathy is often sought by patients with depression. In classical homeopathy, the treatment consists of two main elements: the case history and the prescription of an individually selected homeopathic remed...

    Authors: Ubiratan C Adler, Stephanie Krüger, Michael Teut, Rainer Lüdtke, Iris Bartsch, Lena Schützler, Friedericke Melcher, Stefan N Willich, Klaus Linde and Claudia M Witt
    Citation: Trials 2011 12:43
  5. What study participants think about the nature of a study has been hypothesised to affect subsequent behaviour and to potentially bias study findings. In this trial we examine the impact of awareness of study ...

    Authors: Kypros Kypri, Jim McCambridge, Amanda Wilson, John Attia, Paschal Sheeran, Steve Bowe and Tina Vater
    Citation: Trials 2011 12:42
  6. Current projections indicate that there will be a significant increase in the number of people with dementia in Ireland, from approximately 40,000 at present to 100,000 by 2036. Psychosocial interventions, suc...

    Authors: Eamon O'Shea, Declan Devane, Kathy Murphy, Adeline Cooney, Dympna Casey, Fionnuala Jordan, Andrew Hunter and Edel Murphy
    Citation: Trials 2011 12:41
  7. Low therapeutic adherence to medication is very common. Clinical effectiveness is related to dose rate and route of administration and so poor therapeutic adherence can reduce the clinical benefit of treatment...

    Authors: Pilar Barnestein-Fonseca, José Leiva-Fernández, Francisca Vidal-España, Antonio García-Ruiz, Daniel Prados-Torres and Francisca Leiva-Fernández
    Citation: Trials 2011 12:40
  8. School interventions such as the Incredible Years Classroom Dinosaur Programme targets pupil behaviour across whole classrooms, yet for some children a more intense approach is needed. The Incredible Years Therap...

    Authors: Tracey Bywater, Judy Hutchings, Christopher Whitaker, Ceri Evans and Laura Parry
    Citation: Trials 2011 12:39
  9. Diabetes has already become a threat to the nation and the individual due to its high prevalence rates and high medical expenses. Therefore, preventing diabetes at an earlier stage is very important. Despite a...

    Authors: Sunju Park, Jeong-Su Park, Hoyeon Go, Bo-Hyoung Jang, Yongcheol Shin and Seong-Gyu Ko
    Citation: Trials 2011 12:38
  10. Chronic obstructive pulmonary disease (COPD) is a common disease, associated with cardiovascular disease. Many patients use (long-acting) bronchodilators, whilst they continue smoking alongside. We hypothesise...

    Authors: WD van Dijk, PTJ Scheepers, R Cremers, JWM Lenders, W Klerx, C van Weel, TRJ Schermer and Y Heijdra
    Citation: Trials 2011 12:37
  11. Cognitive behaviour therapy (CBT) is the treatment of choice for common mental health problems, but this approach has only recently been adapted for people with learning disabilities, and there is a limited ev...

    Authors: Paul Willner, Andrew Jahoda, John Rose, Biza Stenfert-Kroese, Kerenza Hood, Julia K Townson, Jacqueline Nuttall, David Gillespie and David Felce
    Citation: Trials 2011 12:36
  12. Up to 85% of patients with schizophrenia demonstrate cognitive dysfunction in at least one domain. Cognitive dysfunction plays a major role in functional outcome. It is hypothesized that addition of cognitive ...

    Authors: Lone Vesterager, Torben Ø Christensen, Birthe B Olsen, Gertrud Krarup, Hysse B Forchhammer, Marianne Melau, Christian Gluud and Merete Nordentoft
    Citation: Trials 2011 12:35
  13. Colorectal cancer is the second most common tumor in developed countries, with a lifetime prevalence of 5%. About one third of these tumors are located in the rectum. Surgery in terms of low anterior resection...

    Authors: Thorsten Löffler, Christoph M Seiler, Inga Rossion, Thomas Kijak, Oliver Thomusch, Renè Hodina, Matthias Krüger, Thomas Simon, Thomas Bruckner, Meinhard Kieser, Markus W Büchler and Jürgen Weitz
    Citation: Trials 2011 12:34
  14. Bone marrow derived stem/progenitor cell transplantation after acute myocardial infarction is safe and effective for improving left ventricular systolic function. However, the improvement of left ventricular s...

    Authors: Hyun-Jae Kang, Min-Kyung Kim, Myung-Gon Kim, Dong-Ju Choi, Jung-Han Yoon, Young-Bae Park and Hyo-Soo Kim
    Citation: Trials 2011 12:33
  15. In unipolar, and bipolar affective disorders, there is a high risk of relapse that increases as the number of episodes increases. Naturalistic follow-up studies suggest that the progressive development of the ...

    Authors: Lars Vedel Kessing, Hanne Vibe Hansen, Ellen Margrethe Christensen, Henrik Dam, Christian Gluud and Jørn Wetterslev
    Citation: Trials 2011 12:32
  16. Serum phosphate is an independent predictor of cardiovascular morbidity and mortality in patients with chronic kidney disease and the general population. There is accumulating evidence that phosphate promotes ...

    Authors: Colin D Chue, Jonathan N Townend, Richard P Steeds and Charles J Ferro
    Citation: Trials 2011 12:30
  17. Research has shown that current claims settlement process can have a negative impact on psychological and physical recovery of personal injury (PI) victims. One of the explanations for the negative impact on h...

    Authors: Nieke A Elbers, Arno J Akkermans, Pim Cuijpers and David J Bruinvels
    Citation: Trials 2011 12:29
  18. The OPERA trial is large cluster randomised trial testing a physical activity intervention to address depression amongst people living in nursing and residential homes for older people. A process evaluation wa...

    Authors: David R Ellard, Stephanie JC Taylor, Suzanne Parsons and Margaret Thorogood
    Citation: Trials 2011 12:28
  19. Depression is common in residents of Residential and Nursing homes (RNHs). It is usually undetected and often undertreated. Depression is associated with poor outcomes including increased morbidity and mortali...

    Authors: Martin Underwood, Sandra Eldridge, Sallie Lamb, Rachel Potter, Bartley Sheehan, Anne-Marie Slowther, Stephanie Taylor, Margaret Thorogood and Scott Weich
    Citation: Trials 2011 12:27
  20. In certain diseases clinical experts may judge that the intervention with the best prospects is the addition of two treatments to the standard of care. This can either be tested with a simple randomized trial ...

    Authors: Marcel Wolbers, Dorothee Heemskerk, Tran Thi Hong Chau, Nguyen Thi Bich Yen, Maxine Caws, Jeremy Farrar and Jeremy Day
    Citation: Trials 2011 12:26
  21. Tuberculous meningitis is the most severe form of tuberculosis. Mortality for untreated tuberculous meningitis is 100%. Despite the introduction of antibiotic treatment for tuberculosis the mortality rate for ...

    Authors: Dorothee Heemskerk, Jeremy Day, Tran Thi Hong Chau, Nguyen Huy Dung, Nguyen Thi Bich Yen, Nguyen Duc Bang, Laura Merson, Piero Olliaro, Thomas Pouplin, Maxine Caws, Marcel Wolbers and Jeremy Farrar
    Citation: Trials 2011 12:25
  22. By tradition colloid solutions have been used to obtain fast circulatory stabilisation in shock, but high molecular weight hydroxyethyl starch (HES) may cause acute kidney failure in patients with severe sepsi...

    Authors: Anders Perner, Nicolai Haase, Jørn Wetterslev, Anders Åneman, Jyrki Tenhunen, Anne Berit Guttormsen, Gudmundur Klemenzson, Frank Pott, Karen Doris Bødker, Per Martin Bådstøløkken, Asger Bendtsen, Peter Søe-Jensen, Hamid Tousi, Morten Bestle, Malgorzata Pawlowicz, Robert Winding…
    Citation: Trials 2011 12:24
  23. Most guidelines recommend a systematic screening of asymptomatic high risk patients with diabetes for silent ischemia, but the clinical benefit of this strategy has not been demonstrated compared with the simp...

    Authors: Michel M Lièvre, Philippe Moulin, Charles Thivolet, Michel Rodier, Vincent Rigalleau, Alfred Penfornis, Alain Pradignac and Michel Ovize
    Citation: Trials 2011 12:23
  24. African Americans experience significant tobacco-related health disparities despite the fact that over half of African American smokers are light smokers (use ≤10 cigarettes per day). African Americans have be...

    Authors: Lisa Sanderson Cox, Babalola Faseru, Matthew S Mayo, Ron Krebill, Tricia S Snow, Carrie A Bronars, Nicole L Nollen, Won S Choi, Kolawole S Okuyemi, Gary A Salzman, Neal L Benowitz, Rachel F Tyndale and Jasjit S Ahluwalia
    Citation: Trials 2011 12:22
  25. For critically ill patients treated in intensive care units (ICU), two feeding strategies are currently being advocated, one by American/Canadian and the other by European expert guidelines. These guidelines d...

    Authors: Michaël P Casaer, Greet Hermans, Alexander Wilmer and Greet Van den Berghe
    Citation: Trials 2011 12:21
  26. The use of thrombolytic therapy in the treatment of thrombosed infrainguinal native arteries and bypass grafts has increased over the years. Main limitation of this treatment modality, however, is the occurren...

    Authors: A Marjolein Schrijver, Michel MPJ Reijnen, Jacques A van Oostayen, Rudolf PJ Tutein Nolthenius, Pieter HM van der Valk, Arjan WJ Hoksbergen, Rutger J Lely, Bram Fioole, Dammis Vroegindeweij, Marc van Leersum and Jean-Paul PM de Vries
    Citation: Trials 2011 12:20
  27. Rheumatoid arthritis is a chronic, disabling disease that can compromise mobility, daily functioning, and health-related quality of life, especially in older adolescents and young adults. In this project, we w...

    Authors: Subhadra Evans, Laura Cousins, Jennie CI Tsao, Saskia Subramanian, Beth Sternlieb and Lonnie K Zeltzer
    Citation: Trials 2011 12:19
  28. Children with attention deficit hyperactivity disorder (ADHD) are hyperactive and impulsive, cannot maintain attention, and have difficulties with social interactions. Medical treatment may alleviate symptoms ...

    Authors: Ole Jakob Storebø, Jesper Pedersen, Maria Skoog, Per Hove Thomsen, Per Winkel, Christian Gluud and Erik Simonsen
    Citation: Trials 2011 12:18
  29. The prevalence of mood difficulties in persons with diabetes is approximately twice that in the general population, affecting the health outcomes and patients' quality of life in an undesirable way. Although s...

    Authors: Mirjana Pibernik-Okanović, Dea Ajduković, Marijana Vučić Lovrenčić and Norbert Hermanns
    Citation: Trials 2011 12:17
  30. Irritable bowel syndrome affects as many as 14% of high school-aged students. Symptoms include discomfort in the abdomen, along with diarrhea and/or constipation and other gastroenterological symptoms that can...

    Authors: Subhadra Evans, Laura Cousins, Jennie CI Tsao, Beth Sternlieb and Lonnie K Zeltzer
    Citation: Trials 2011 12:15
  31. Loss of hand function is one of the most devastating consequences of spinal cord injury. Intensive hand training provided on an instrumented exercise workstation in conjunction with functional electrical stimu...

    Authors: Lisa A Harvey, Sarah A Dunlop, Leonid Churilov, Ya-Seng Arthur Hsueh and Mary P Galea
    Citation: Trials 2011 12:14
  32. The Ouabain and Adducin for Specific Intervention on Sodium in Hypertension (OASIS-HT) Trial was a phase-2 dose-finding study of rostafuroxin, a digitoxygenin derivative, which selectively antagonizes the effe...

    Authors: Jan A Staessen, Lutgarde Thijs, Katarzyna Stolarz-Skrzypek, Antonella Bacchieri, John Barton, Ezio degli Espositi, Peter W de Leeuw, Mirosław Dłużniewski, Nicola Glorioso, Andrzej Januszewicz, Paolo Manunta, Viktor Milyagin, Yuri Nikitin, Miroslav Souček, Chiara Lanzani, Lorena Citterio…
    Citation: Trials 2011 12:13
  33. There is a large treatment gap with few community services for people with schizophrenia in low income countries largely due to the shortage of specialist mental healthcare human resources. Community based reh...

    Authors: Sudipto Chatterjee, Morven Leese, Mirja Koschorke, Paul McCrone, Smita Naik, Sujit John, Hamid Dabholkar, Kimberley Goldsmith, Madhumitha Balaji, Mathew Varghese, Rangaswamy Thara, Vikram Patel and Graham Thornicroft
    Citation: Trials 2011 12:12
  34. Sub-threshold depression is common, impairs functioning, and increases the risk of developing major depression. Although psychological treatments have been investigated for sub-threshold depression, they are c...

    Authors: Amy J Morgan, Anthony F Jorm and Andrew J Mackinnon
    Citation: Trials 2011 12:11
  35. Probucol, a cholesterol-lowering agent that paradoxically also lowers high-density lipoprotein cholesterol has been shown to prevent progression of atherosclerosis. The antiplatelet agent cilostazol, which has...

    Authors: Young-Guk Ko, Byeong-Keuk Kim, Byoung Kwon Lee, Woong Chol Kang, Seung Hyuk Choi, Sang Wook Kim, Jong Ho Lee, Myoungsook Lee, Yasuhiro Honda, Peter J Fitzerald and Won-Heum Shim
    Citation: Trials 2011 12:10
  36. Financial conflicts of interest (fCOI) can introduce actions that bias clinical trial results and reduce their objectivity. We obtained information from investigators about adherence to practices that minimize...

    Authors: Paula A Rochon, Melanie Sekeres, John Hoey, Joel Lexchin, Lorraine E Ferris, David Moher, Wei Wu, Sunila R Kalkar, Marleen Van Laethem, Andrea Gruneir, Jennifer Gold, James Maskalyk, David L Streiner, Nathan Taback and An-Wen Chan
    Citation: Trials 2011 12:9
  37. Traumatic brain injury is a major cause of death and severe disability worldwide with 1,000,000 hospital admissions per annum throughout the European Union.

    Authors: Peter JD Andrews, Helen Louise Sinclair, Claire G Battison, Kees H Polderman, Giuseppe Citerio, Luciana Mascia, Bridget A Harris, Gordon D Murray, Nino Stocchetti, David K Menon, Haleema Shakur and Daniel De Backer
    Citation: Trials 2011 12:8
  38. Recruitment and retention of participants are critical to the success of a randomised controlled trial. Gaining the views of potential trial participants who decline to enter a trial and of trial participants ...

    Authors: Helen C Eborall, Marlene CW Stewart, Sarah Cunningham-Burley, Jackie F Price and F Gerry R Fowkes
    Citation: Trials 2011 12:7
  39. Chronic Obstructive Pulmonary Disease (COPD) is a prevalent debilitating long term condition. It is the second most common cause of emergency admission to hospital in the UK and remains one of the most costly ...

    Authors: Deborah A Fitzsimmons, Jill Thompson, Mark Hawley and Gail A Mountain
    Citation: Trials 2011 12:6
  40. This trial aims at testing the efficacy of weekly reminder and motivational text messages, compared to usual care in improving adherence to Highly Active Antiretroviral Treatment in patients attending a clinic...

    Authors: Lawrence Mbuagbaw, Lahana Thabane, Pierre Ongolo-Zogo, Richard T Lester, Edward Mills, Jimmy Volmink, David Yondo, Marie José Essi, Renée-Cecile Bonono-Momnougui, Robert Mba, Jean Serge Ndongo, Francois C Nkoa and Henri Atangana Ondoa
    Citation: Trials 2011 12:5
  41. Clinically useful treatment moderators of Major Depressive Disorder (MDD) have not yet been identified, though some baseline predictors of treatment outcome have been proposed. The aim of iSPOT-D is to identif...

    Authors: Leanne M Williams, A John Rush, Stephen H Koslow, Stephen R Wisniewski, Nicholas J Cooper, Charles B Nemeroff, Alan F Schatzberg and Evian Gordon
    Citation: Trials 2011 12:4
  42. The feasibility of conducting a large-scale Polypill clinical trial in developing countries remains unclear. More information is needed regarding the efficacy in reducing the risk factors of cardiovascular dis...

    Authors: Elsayed Z Soliman, Shanthi Mendis, Wasantha P Dissanayake, Noel P Somasundaram, Padma S Gunaratne, I Kumudini Jayasingne and Curt D Furberg
    Citation: Trials 2011 12:3
  43. Pregnant women living with HIV (WLH) face daily challenges maintaining their own and their babies' health and mental health. Standard Prevention of Maternal to Child Transmission (PMTCT) programs are not desig...

    Authors: Mary-Jane Rotheram-Borus, Linda Richter, Heidi Van Rooyen, Alastair van Heerden, Mark Tomlinson, Alan Stein, Tamsen Rochat, Julia de Kadt, Nonhle Mtungwa, Lungile Mkhize, Lindo Ndlovu, Lungile Ntombela, W Scott Comulada, Katherine A Desmond and Erin Greco
    Citation: Trials 2011 12:2
  44. The Vaccine Assessment using Linked Data (VALiD) trial compared opt-in and opt-out parental consent for a population-based childhood vaccine safety surveillance program using data linkage. A subsequent telepho...

    Authors: Jesia G Berry, Philip Ryan, Annette J Braunack-Mayer, Katherine M Duszynski, Vicki Xafis and Michael S Gold
    Citation: Trials 2011 12:1
  45. It has been demonstrated that cognitive behavioural therapy (CBT) has a moderate effect on symptom reduction and on general well being of patients suffering from psychosis. However, questions regarding the spe...

    Authors: Stefan Klingberg, Andreas Wittorf, Christoph Meisner, Wolfgang Wölwer, Georg Wiedemann, Jutta Herrlich, Andreas Bechdolf, Bernhard W Müller, Gudrun Sartory, Michael Wagner, Tilo Kircher, Hans-Helmut König, Corinna Engel and Gerhard Buchkremer
    Citation: Trials 2010 11:123
  46. Contrast-induced nephropathy (CIN) is a serious clinical problem associated with increased morbidity and mortality, particularly in patients with chronic renal insufficiency. Although some agents including hyd...

    Authors: Kyungil Park, Woo-Young Chung, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim and Young-Bae Park
    Citation: Trials 2010 11:122
  47. Asthma is a major health problem and has significant mortality around the world. Although the symptoms can be controlled by drug treatment in most patients, effective low-risk, non-drug strategies could consti...

    Authors: Rixin Chen, Mingren Chen, Jun Xiong, Fan Yi, Zhenhai Chi and Bo Zhang
    Citation: Trials 2010 11:121
  48. Observational studies have documented a potential protective effect of physical exercise in older adults who are at risk for developing Alzheimer's disease. The Fitness for the Ageing Brain II (FABS II) study ...

    Authors: Elizabeth V Cyarto, Kay L Cox, Osvaldo P Almeida, Leon Flicker, David Ames, Gerard Byrne, Keith D Hill, Christopher D Beer, Dina LoGiudice, Kana Appadurai, Muireann Irish, Emma Renehan and Nicola T Lautenschlager
    Citation: Trials 2010 11:120

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