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  1. Endovascular or intra-arterial treatment (IAT) increases the likelihood of recanalization in patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion. However, a beneficial effe...

    Authors: Puck SS Fransen, Debbie Beumer, Olvert A Berkhemer, Lucie A van den Berg, Hester Lingsma, Aad van der Lugt, Wim H van Zwam, Robert J van Oostenbrugge, Yvo BWEM Roos, Charles B Majoie and Diederik WJ Dippel
    Citation: Trials 2014 15:343
  2. NHS Health Checks is a new program for primary prevention of heart disease, stroke, diabetes, chronic kidney disease, and vascular dementia in adults aged 40 to 74 years in England. Individuals without existin...

    Authors: Alice S Forster, Caroline Burgess, Lisa McDermott, Alison J Wright, Hiten Dodhia, Mark Conner, Jane Miller, Caroline Rudisill, Victoria Cornelius and Martin C Gulliford
    Citation: Trials 2014 15:342
  3. The periodic health check-up has been a fundamental part of routine medical practice for decades, despite a lack of consensus regarding its value in health promotion and disease prevention. A large-scale Danis...

    Authors: Helle Terkildsen Maindal, Henrik Støvring and Annelli Sandbaek
    Citation: Trials 2014 15:341
  4. In sub-Saharan Africa, malaria continues to cause over 10,000 maternal deaths and 75,000 to 200,000 infant deaths. Successful control of malaria in pregnancy could save lives of mothers and babies and is an es...

    Authors: Susana Scott, Petra F Mens, Halidou Tinto, Alain Nahum, Esmée Ruizendaal, Franco Pagnoni, Koen Peeters Grietens, Lindsay Kendall, Kalifa Bojang, Henk Schallig and Umberto D’Alessandro
    Citation: Trials 2014 15:340
  5. Cardiac surgery has been shown to result in a significant decrease of the antioxidant selenium, which is associated with the development of multiorgan dysfunction and increased mortality. Thus, a large-scale s...

    Authors: Christian Stoppe, Bernard McDonald, Steffen Rex, William Manzanares, Richard Whitlock, Stephen Fremes, Robert Fowler, Yoan Lamarche, Patrick Meybohm, Christoph Haberthür, Rolf Rossaint, Andreas Goetzenich, Gunnar Elke, Andrew Day and Daren K Heyland
    Citation: Trials 2014 15:339
  6. Despite administration of annual influenza vaccination, influenza-associated complications in transplant recipients continue to be an important cause of hospitalization and death. Although influenza vaccinatio...

    Authors: Juliana Martinez-Atienza, Clara Rosso-Fernández, Cristina Roca, Teresa A Aydillo, Joan Gavaldà, Asunción Moreno, Jose M Montejo, Julian Torre-Cisneros, M Carmen Fariñas, Jesus Fortun, Nuria Sabé, Patricia Muñoz, Marino Blanes-Julia, Alejandro Suárez-Benjumea, Francisco López-Medrano, Pilar Pérez-Romero…
    Citation: Trials 2014 15:338
  7. Chronic obstructive pulmonary disease (COPD) is a chronic, progressively debilitating condition that is prevalent in the US and worldwide. Patients suffer from progressive dyspnea and exercise intolerance. Phy...

    Authors: Gloria Y Yeh, Peter M Wayne, Daniel Litrownik, David H Roberts, Roger B Davis and Marilyn L Moy
    Citation: Trials 2014 15:337
  8. Increasing physical activity is known to have health benefits for people with hypertension and related conditions. Current general practitioner referrals for gym-based exercise increase physical activity but m...

    Authors: Chris Fife-Schaw, Simon de Lusignan, Joe Wainwright, Hannah Sprake, Suzannah Laver, Victoria Heald, Julian Orton, Matt Prescott, Helen Carr and Mark O’Neill
    Citation: Trials 2014 15:336
  9. There is a concern in the literature that harm from interventions is insufficiently documented in clinical trials in general, and in those assessing psychological treatments in particular. A recent decision by...

    Authors: Conor Duggan, Glenys Parry, Mary McMurran, Kate Davidson and Jane Dennis
    Citation: Trials 2014 15:335
  10. In August 2010, the Federal Joint Committee (G-BA) decided that negative pressure wound therapy (NPWT) would not be reimbursable in German ambulatory care. This decision was based on reports from the Institute...

    Authors: Dörthe Seidel, Tim Mathes, Rolf Lefering, Martin Storck, Holger Lawall and Edmund A M Neugebauer
    Citation: Trials 2014 15:334
  11. Microvascular angina (MVA) is characterized by anginal chest pain, an abnormal stress test, and normal coronary arteries on coronary angiography. Although the exact pathogenesis remains unclear, endothelial dy...

    Authors: Sung-Ji Park, Jin Joo Park, Dong-Ju Choi, Eun Ju Chun, Sang Il Choi, Sung Mok Kim, Shin Yi Jang, Soyeon Ahn and Yeon Hyeon Choe
    Citation: Trials 2014 15:333
  12. Community-acquired pneumonia (CAP) is considered the leading cause of death from infectious disease in developed countries, while complications of CAP - sepsis being the most common and challenging - increase ...

    Authors: Hannah Greenwood, Jaimin Patel, Rahul Mahida, Qian Wang, Dhruv Parekh, Rachel CA Dancer, Heena Khiroya, Elizabeth Sapey and David R Thickett
    Citation: Trials 2014 15:332
  13. N-methyl-D-aspartate receptor antagonists are potential therapies for neuropathic pain, and memantine has a good tolerance profile. A preclinical study recently reported that presurgery memantine may prevent n...

    Authors: Gisèle Pickering, Véronique Morel, Dominique Joly, Christine Villatte, Delphine Roux, Claude Dubray and Bruno Pereira
    Citation: Trials 2014 15:331
  14. Breast neoplasms are the second most common type of cancer worldwide, and radiation therapy is a key component of their treatment. Acute skin reactions are one of the most common side effects of radiation ther...

    Authors: Marina Moreira Costa, Sidney Benedito Silva, Ana Luiza Pereira Quinto, Priscilla Furtado Souza Pasquinelli, Vanessa de Queiroz dos Santos, Gabriela de Cássia Santos and Daniela Francescato Veiga
    Citation: Trials 2014 15:330
  15. Viability seems to be important in preventing ventricular remodeling after acute myocardial infarction (AMI). We investigated the influence of viability, as demonstrated with low-dose dobutamine echocardiograp...

    Authors: Ramon B van Loon, Gerrit Veen, Otto Kamp, Leo HB Baur and Albert C van Rossum
    Citation: Trials 2014 15:329
  16. Gentamicin is used as a therapeutic agent for Ménière’s disease because of its vestibulotoxicity causing chemo-ablation of the vestibular sensory epithelia. Its use has increased in recent years. However, ther...

    Authors: Hendrik G Bremer, Ingrid van Rooy, Bas Pullens, Carla Colijn, Inge Stegeman, Hester J van der Zaag-Loonen, Peter Paul van Benthem, Sjaak F L Klis, Wilko Grolman and Tjasse D Bruintjes
    Citation: Trials 2014 15:328
  17. Sleep deprivation is common in critically ill patients in intensive care units (ICU). It can result in delirium, difficulty weaning, repeated nosocomial infections, prolonged ICU length of stay and increased I...

    Authors: Huawei Huang, Li Jiang, Ling Shen, Guobin Zhang, Bo Zhu, Jiajia Cheng and Xiuming Xi
    Citation: Trials 2014 15:327
  18. Young adulthood (age 18 to 35) is a high-risk period for unhealthy weight gain. Few studies have recruited for prevention of weight gain, particularly in young adults. This paper describes the recruitment prot...

    Authors: Deborah F Tate, Jessica G LaRose, Leah P Griffin, Karen E Erickson, Erica F Robichaud, Letitia Perdue, Mark A Espeland and Rena R Wing
    Citation: Trials 2014 15:326
  19. After kidney transplantation, immunosuppressive therapy causes impaired cellular immune defense leading to an increased risk of viral complications. Trough level monitoring of immunosuppressants is insufficien...

    Authors: Thurid Ahlenstiel-Grunow, Armin Koch, Anika Großhennig, Cornelia Frömke, Martina Sester, Urban Sester, Christoph Schröder and Lars Pape
    Citation: Trials 2014 15:324
  20. Patients’ treatment preferences are often cited as barriers to recruitment in randomized controlled trials (RCTs). We investigated how RCT recruiters reacted to patients’ treatment preferences and identified k...

    Authors: Nicola Mills, Jane M Blazeby, Freddie C Hamdy, David E Neal, Bruce Campbell, Caroline Wilson, Sangeetha Paramasivan and Jenny L Donovan
    Citation: Trials 2014 15:323
  21. Functional Strength Training (FST) could enhance recovery late after stroke. The aim of this study was to evaluate the feasibility of a subsequent fully powered, randomized controlled trial.

    Authors: Kathryn Mares, Jane Cross, Allan Clark, Susan Vaughan, Garry R Barton, Fiona Poland, Kate McGlashan, Martin Watson, Phyo K Myint, Marie-Luce O’Driscoll and Valerie M Pomeroy
    Citation: Trials 2014 15:322
  22. Providing care for adolescents with type 1 diabetes is complex, demanding, and often unsuccessful. Guided self-determination (GSD) is a life skills approach that has been proven effective in caring for adults ...

    Authors: Gitte R Husted, Birger Thorsteinsson, Bente Appel Esbensen, Christian Gluud, Per Winkel, Eva Hommel and Vibeke Zoffmann
    Citation: Trials 2014 15:321
  23. Major depressive disorder (MDD) is a long-lasting disorder with frequent relapses that have significant effects on the patient’s family. Family psychoeducation is recognized as part of the optimal treatment fo...

    Authors: Fujika Katsuki, Hiroshi Takeuchi, Norio Watanabe, Nao Shiraishi, Tohru Maeda, Yosuke Kubota, Masako Suzuki, Atsurou Yamada and Tatsuo Akechi
    Citation: Trials 2014 15:320
  24. Case conferences for people with dementia and challenging behaviors (e.g., apathy) are recommended as useful tools that enable staff in nursing homes to understand the behavior of people with this type of dise...

    Authors: Sven Reuther, Daniela Holle, Ines Buscher, Olga Dortmann, René Müller, Sabine Bartholomeyczik and Margareta Halek
    Citation: Trials 2014 15:319
  25. The management of patients suffering from opioid-refractory cancer pain with a neuropathic component remains an important challenge for healthcare workers. Only one retrospective study specifically reported th...

    Authors: Sébastien Salas, Pascal Auquier, Florence Duffaud, Stéphanie Ranque Garnier, Mélanie Deschamps, Stéphane Honoré, Patrick Sudour and Karine Baumstarck
    Citation: Trials 2014 15:318
  26. Uveal melanoma is the most common primary intraocular malignancy in adults. Despite successful control of the primary tumor, metastatic disease will ultimately develop in approximately 50% of patients, with th...

    Authors: Roger Olofsson, Lars Ny, Malin Sternby Eilard, Magnus Rizell, Christian Cahlin, Ulrika Stierner, Ulf Lönn, Johan Hansson, Ingrid Ljuslinder, Lotta Lundgren, Gustav Ullenhag, Jens Folke Kiilgaard, Jonas Nilsson and Per Lindnér
    Citation: Trials 2014 15:317

    The Erratum to this article has been published in Trials 2015 16:334

  27. Stroke has a huge impact, leaving more than a third of affected people with lasting disability and rehabilitation remains a cornerstone treatment in the National Health Service (NHS). Recovery of mobility and ...

    Authors: Bipin B Bhakta, Suzanne Hartley, Ivana Holloway, J Alastair Couzens, Gary A Ford, David Meads, Catherine M Sackley, Marion F Walker, Sharon P Ruddock and Amanda J Farrin
    Citation: Trials 2014 15:316
  28. The increasing prevalence and associated cost of treating chronic obstructive pulmonary disease (COPD) is unsustainable, and focus is needed on self-management and prevention of hospital admissions. Telehealth...

    Authors: Claire L Bentley, Gail A Mountain, Jill Thompson, Deborah A Fitzsimmons, Kinga Lowrie, Stuart G Parker and Mark S Hawley
    Citation: Trials 2014 15:313
  29. The menopausal transition (MT) is a biological inevitability for all ageing women that can be associated with changes in mood, including depressive symptoms. There is tentative evidence that women who develop ...

    Authors: Osvaldo P Almeida, Kylie Marsh, Leon Flicker, Martha Hickey, Andrew Ford and Moira Sim
    Citation: Trials 2014 15:312
  30. Cholangiocellular carcinoma is the second most common primary liver cancer after hepatocellular carcinoma. Over the last 30 years, the incidence of intrahepatic cholangiocellular carcinoma has risen continuous...

    Authors: Roman Kloeckner, Christian Ruckes, Kai Kronfeld, Marcus Alexander Wörns, Arndt Weinmann, Peter Robert Galle, Hauke Lang, Gerd Otto, Waltraud Eichhorn, Mathias Schreckenberger, Christoph Dueber and Michael Bernhard Pitton
    Citation: Trials 2014 15:311
  31. The ‘external validity’ of randomized controlled trials is an important measure of quality, but is often not formally assessed. Trials concerning mass drug administration for helminth control are likely to gui...

    Authors: James D Millard, Lawrence Muhangi, Moses Sewankambo, Juliet Ndibazza, Alison M Elliott and Emily L Webb
    Citation: Trials 2014 15:310
  32. Depression is a common and disabling condition. In Chile, assistance is guaranteed by law through a national program for depression in primary care services, and there is evidence of effective treatment for de...

    Authors: Vania Martínez, Pablo Martínez, Paul A Vöhringer, Ricardo Araya and Graciela Rojas
    Citation: Trials 2014 15:309
  33. Substance misuse in those with severe mental health problems is common and associated with poor engagement in treatment and treatment outcomes. Up to 44% of those admitted into psychiatric inpatient facilities...

    Authors: Hermine L Graham, Max Birchwood, Emma Griffith, Nick Freemantle, Paul McCrone, Chrysi A Stefanidou, Kathryn Walsh, Latoya Clarke, Arsal Rana and Alex Copello
    Citation: Trials 2014 15:308
  34. Informed consent of trial participants is both an ethical and a legal requirement. When facing a decision about trial participation, potential participants are provided with information about the trial and hav...

    Authors: Katie Gillies, Glyn Elwyn and Jonathan Cook
    Citation: Trials 2014 15:307
  35. Despite the use of evidence-based preventive measures, delirium affects about 40% of patients following cardiac surgery with the potential for serious clinical complications and anxiety for caregivers. There i...

    Authors: Tanya Mailhot, Sylvie Cossette, Anne Bourbonnais, José Côté, André Denault, Marie-Claude Côté, Yoan Lamarche and Marie-Claude Guertin
    Citation: Trials 2014 15:306
  36. Today’s children are more overweight than previous generations and physical inactivity is a contributing factor. Modelling and promoting positive behaviour in the early years is imperative for the development ...

    Authors: Kristi B Adamo, Nick Barrowman, Patti Jean Naylor, Sanni Yaya, Alysha Harvey, Kimberly P Grattan and Gary S Goldfield
    Citation: Trials 2014 15:305
  37. Recruiting stroke patients into acute treatment trials is challenging because of the urgency of clinical diagnosis, treatment, and trial inclusion. Automated alerts that identify emergency patients promptly ma...

    Authors: Kati Jegzentis, Tim Nowe, Peter Brunecker, Matthias Endres, Bernd Haferkorn, Christoph Ploner, Jens Steinbrink and Gerhard Jan Jungehulsing
    Citation: Trials 2014 15:304
  38. An intervention was designed to introduce rapid diagnostics tests for malaria (mRDTs) into registered drug shops in Uganda to encourage rational and appropriate treatment of malaria with artemisinin-based comb...

    Authors: Anthony K Mbonye, Pascal Magnussen, Clare IR Chandler, Kristian S Hansen, Sham Lal, Bonnie Cundill, Caroline A Lynch and Siân E Clarke
    Citation: Trials 2014 15:303
  39. The Grip on Challenging Behavior care program for managing challenging behavior was implemented in the dementia special care units of 17 Dutch nursing homes. A process evaluation of the implementation of the c...

    Authors: Sandra A Zwijsen, Martin Smalbrugge, Jan A Eefsting, Debby L Gerritsen, Cees MPM Hertogh and Anne Margriet Pot
    Citation: Trials 2014 15:302
  40. The traditional Chinese theory of acupuncture emphasizes that the intensity of acupuncture must reach a threshold to generate de qi (a specific and compound sensation during the acupuncture), which is necessary t...

    Authors: Qing Chen, Qinxiu Zhang, Luyun Jiang, Xinrong Li, Yang Liu, Yan Xie, Shan Mu, Ying Liu, Xiaopei Wang, Yunzhi Yu and Min Li
    Citation: Trials 2014 15:301
  41. Current guidelines recommend treatment of significant coronary artery disease by concomitant coronary artery bypass grafting (CABG) in patients undergoing surgical aortic valve replacement. However there is no...

    Authors: Muhammed Zeeshan Khawaja, Duolao Wang, Stuart Pocock, Simon Robert Redwood and Martyn Rhys Thomas
    Citation: Trials 2014 15:300
  42. In the United States certain minority groups, such as racial/ethnic immigrant women, are less likely than non-Hispanic White women to be screened for cervical cancer. Barriers to such care include health insur...

    Authors: Olveen Carrasquillo, Sheila McCann, Antony Amofah, Larry Pierre, Brendaly Rodriguez, Yisel Alonzo, Kumar Ilangovan, Martha Gonzalez, Dinah Trevil, Margaret M Byrne, Tulay Koru-Sengul and Erin Kobetz
    Citation: Trials 2014 15:299
  43. The United Nations Millennium Development Goals include targets for the health of children under five years old. Poor health is linked to poverty and microfinance initiatives are economic interventions that ma...

    Authors: Shalini Ojha, Lisa Szatkowski, Ranjeet Sinha, Gil Yaron, Andrew Fogarty, Stephen Allen, Sunil Choudhary and Alan R Smyth
    Citation: Trials 2014 15:298
  44. Tinnitus occurs in a large part of the general population with prevalences ranging from 10% to 15% in an adult population. One subtype is cervicogenic somatic tinnitus, arising from cervical spine dysfunctions...

    Authors: Sarah Michiels, Willem De Hertogh, Steven Truijen and Paul Van de Heyning
    Citation: Trials 2014 15:297
  45. The use of nicotine replacement therapy before quitting smoking is called nicotine preloading. Standard smoking cessation protocols suggest commencing nicotine replacement therapy only on the first day of quit...

    Authors: Nicola Lindson-Hawley, Tim Coleman, Graeme Docherty, Peter Hajek, Sarah Lewis, Deborah Lycett, Andy McEwen, Hayden McRobbie, Marcus R Munafò, Steve Parrott and Paul Aveyard
    Citation: Trials 2014 15:296
  46. The results of preclinical studies suggest that baclofen may be useful in the treatment of stroke patients with persistent hiccups. This study was aimed to assess the possible efficacy of baclofen for the trea...

    Authors: Cuie Zhang, Ruifen Zhang, Shuangyan Zhang, Meiling Xu and Shuyan Zhang
    Citation: Trials 2014 15:295
  47. Depression is a debilitating mental health problem that tends to run a chronic, recurrent course. Even when effectively treated, relapse and recurrence rates remain high. Accordingly, interventions need to foc...

    Authors: Tim Dalgleish, Anna Bevan, Anna McKinnon, Lauren Breakwell, Viola Mueller, Isobel Chadwick, Susanne Schweizer, Caitlin Hitchcock, Peter Watson, Filip Raes, Laura Jobson and Aliza Werner-Seidler
    Citation: Trials 2014 15:293

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